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  • 1
    Electronic Resource
    Electronic Resource
    Diminished cord blood lymphocytel-selectin expression in neonatal bacterial infection (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 519-522 
    Details
    ISSN: 1432-1076
    Keywords: l-Selectin ; Lymphocytes ; Infection ; Newborn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract l-Selectin, a leukocyte surface glycoprotein involved in white blood cell extravasation, is rapidly down-regulated after leukocyte activation. We prospectively determined lymphocytel-selectin expression in freshly obtained cord blood samples of 98 neonates (gestational age 25–42 weeks). In eight infants with bacterial infection, the mean percentage ofl-selectinhigh lymphocytes was 32.5% (SD 20.1%), compared to 60.1% (SD 18.7%) in the control group (P〈0.01). A percentage ofl-selectinhigh lymphocytes of less than 42% had a sensitivity of 75% and a specificity of 82% in identifying infected newborns. Cord blood lymphocytel-selectin expression was independent of gestational age, birth weight, umbilical artery pH, hematocrit, white blood cell count, absolute neutrophil count, C-reactive protein level, or maternal fever before delivery while there was a weak correlation with the newborn's immature/total ratio and platelet count. To our knowledge, this is the first report demonstrating downregulation of human lymphocytel-selectin expression following activation of the immune system in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955064
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  • 2
    Electronic Resource
    Electronic Resource
    Neurodevelopmental outcome after prenatal exposure to opiates (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 724-730 
    Details
    ISSN: 1432-1076
    Keywords: Key words Opiate-exposed infants ; Drug withdrawal ; Clinical and neurodevelopmental outcome ; Griffiths Developmental Scale ; Prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To study the developmental effects of prenatal exposure to opiates, a prospective follow up study of 34 drug-exposed (opiates and nicotine) and 42 reference infants (nicotine exposure only) was conducted from January 1992 to September 1995. At the time of delivery, 12 of 34 mothers used opiates without medical control. Twenty-two mothers participated in a methadone maintenance programme. At 1 year, the average Griffiths Developmental Quotient (DQ) was lower in the drug-exposed group (mean: 100.5 vs. references 107.9; P 〈 0.001). This difference was mainly due to lower subscales “locomotor” (mean 100.8 vs. 111.4; P 〈 0.05) and “intellectual performance” (mean 100.8 vs. 108.5; P 〈 0.05) in the drug-exposed group. Severe developmental retardation mean DQ (−2 SD) was diagnosed in 2 drug-exposed infants. Mild developmental retardation (mean DQ: 1 SD– 〉 2 SD) was found in 7 drug-exposed and in 3 reference infants (P 〈 0.05). Neurological abnormalities were found more frequently in the drug-exposed group (11 vs. 3 infants; P 〈 0.01). Among the opiate-exposed infants, the subscales “hearing and speech” and “intellectual performance” were lower in the uncontrolled drug-using than in the methadone group. The 17 fostered infants showed no difference in developmental outcome compared with the 10 infants living with their biological parents (mean DQ: 100.0 versus 101.3). Conclusions At 1 year infants prenatally exposed to opiates are at risk for mild psychomotor developmental impairment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050923
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  • 3
    Electronic Resource
    Electronic Resource
    The CRIB (Clinical Risk Index for Babies) score and neurodevelopmental impairment at one year corrected age in very low birth weight infants (2000)
    Springer
    Intensive care medicine 26 (2000), S. 325-329 
    Details
    ISSN: 1432-1238
    Keywords: Key words Newborn infants ; Prematurity ; CRIB score ; Risk factors ; Mortality ; Impairment ; Outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To assess the ability of the Clinical Risk Index for Babies (CRIB) to predict long-term neurodevelopmental impairment in very low birth weight (VLBW) infants.¶Design: Single-center cohort study.¶Setting: Tertiary neonatal care hospital and follow-up clinic.¶Patients: Four hundred fifty-five VLBW infants consecutively admitted from 1992 to 1997 inclusive.¶Measurements and results: Calculations of CRIB scores from birth weight, gestational age, the presence of congenital malformations, worst base excess, maximum and minimum appropriate fraction of inspired oxygen (FIO2) during the first 12 h of life was possible in 430 infants. Three hundred eighty-six infants survived until discharge (89 %) and 352 (91 %) were examined at 1 year corrected age using the Griffiths scales of mental development. Major neurodevelopmental impairment (general quotient 〈 2 standard deviations below average) was observed in 76 infants (22 %). CRIB scores and the individual CRIB components differed significantly between infants with and those without neurodevelopmental impairment. By logistic regression analysis, CRIB scores and minimum FIO2 were independent predictors of death, while CRIB and maximum FIO2 were independently associated with neurodevelopmental impairment. For combined poor outcome (death or impairment), CRIB, minimum and maximum FIO2 were independent predictors. In predicting major neurodevelopmental impairment, the area under the receiver operating characteristic curve for CRIB (0.703 ± 0.035) did not differ significantly from that of birth weight (0.697 ± 0.035) or any other CRIB component.¶Conclusion: While high CRIB scores are associated with major neurodevelopmental impairment, the CRIB score is of limited value for stratification in randomized trials or for adjustments in comparing performance between hospitals with neurodevelopmental impairment as the main outcome measure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340051157
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