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  • 1
    Electronic Resource
    Electronic Resource
    Solution structure of P05-NH2, a scorpion toxin analog with high affinity for the apamin-sensitive potassium channel (1993)
    s.l. : American Chemical Society
    Biochemistry 32 (1993), S. 11969-11976 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00096a005
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  • 2
    Electronic Resource
    Electronic Resource
    Cortical control of presynaptic inhibition of Ia afferents in humans (1998)
    Springer
    Experimental brain research 119 (1998), S. 415-426 
    Details
    ISSN: 1432-1106
    Keywords: Key words Cortical stimulation ; Ia afferents ; Presynaptic inhibition ; Spinal interneurones ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The effect of transcranial magnetic stimulation was investigated on presynaptic inhibition of Ia terminals in the human upper and lower limb. Presynaptic inhibition of Ia afferents was assessed by three different and independent methods: (1) heteronymous Ia facilitation of the H-reflex (assessing ongoing presynaptic inhibition of Ia afferents in the conditioning volley); (2) long-lasting inhibition of the H-reflex by a group I volley (D1 inhibition, assessing presynaptic inhibition on Ia afferents in the test volley); (3) measurement of the monosynaptic Ia peak evoked in single motor units by a homonymous or heteronymous volley (post stimulus time histogram method). The first two methods were used on the lower limb; the last two on the upper limb. Provided that the corticospinal volley and the explored Ia volley were directed to the same target motoneurones, cortical stimulation evoked significant and congruent changes: (1) In the lower limb, transcranial stimulation provided increased heteronymous Ia facilitation and decreased D1 inhibition, both of which suggest a decrease in presynaptic inhibition of Ia afferents; (2) in the upper limb, transcranial stimulation provided an increase in the radial-induced inhibition of the wrist flexor H-reflex and a decrease in the peak of monosynaptic Ia excitation in single units, both of which suggest an increase in presynaptic inhibition. Selectivity of corticospinal effects was explored by testing presynaptic inhibition of Ia afferents to soleus motoneurones and focusing the transcranial stimulation to excite preferentially different motor nuclei (soleus, quadriceps and tibialis anterior). A cortical-induced decrease in presynaptic inhibition of Ia afferents was seen when, and only when, cortical and peripheral Ia volleys were directed to the same motor nucleus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050357
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  • 3
    Electronic Resource
    Electronic Resource
    Pattern of heteronymous recurrent inhibition in the human lower limb (1994)
    Springer
    Experimental brain research 102 (1994), S. 149-159 
    Details
    ISSN: 1432-1106
    Keywords: Recurrent inhibition ; Renshaw cells ; Spinal reflexes ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Changes in the firing probability of motor units belonging to leg and thigh muscles were used to describe the pattern of distribution of recurrent inhibition evoked by motor discharges from various motor nuclei in the human lower limb. Discharges of units in soleus, gastrocnemius medialis, peroneus brevis, tibialis anterior, quadriceps and biceps femoris were investigated following a conditioning stimulation which evoked either a monosynaptic reflex in quadriceps, triceps surae or peroneal motor neurones, or an antidromic motor volley in one of the following nerves: inferior soleus, gastrocnemius medialis, superficial peroneal, deep peroneal, or femoral nerve. In many motor unit-nerve combinations a trough in the post-stimulus time histogram, indicating an inhibition, appeared immediately after the heteronymous Ia excitation. This inhibition is thought to be Renshaw in origin, because it appeared and increased with the conditioning motor discharge, was independent of the conditioning stimulus intensity per se and had a long duration. These recurrent connections were widely distributed with a pattern very similar to that described for heteronymous monosynaptic Ia excitation. In particular Renshaw coupling between muscles operating at different joints seems to be the rule in the human lower limb.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232447
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  • 4
    Electronic Resource
    Electronic Resource
    Changes in polysynaptic Ia excitation to quadriceps motoneurones during voluntary contraction in man (1986)
    Springer
    Experimental brain research 63 (1986), S. 436-438 
    Details
    ISSN: 1432-1106
    Keywords: Polysynaptic Ia excitation ; Spinal interneurones ; Voluntary movement ; Human quadriceps
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Homonymous Ia facilitation of quadriceps (Q) motoneurones (MNs) was significantly larger during (and at the onset of) a very weak Q voluntary contraction than at rest. This increase in Ia facilitation only appeared with a conditioning-test interval within the narrow range of 5–9 ms, which fits the time course of the recently described polysynaptic Ia excitation to Q MNs. This suggests that interneurones mediating polysynaptic Ia excitatory effects to Q MNs receive a strong descending excitation during such a contraction. It is therefore argued that these interneurones might mediate part of the descending command to Q MNs during voluntary contraction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236863
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  • 5
    Electronic Resource
    Electronic Resource
    Further evidence for non-monoynaptic group I excitation of motoneurones in the human lower limb (1997)
    Springer
    Experimental brain research 115 (1997), S. 35-46 
    Details
    ISSN: 1432-1106
    Keywords: Key words Non-monosynaptic group I excitation ; Group II excitation ; Spinal reflexes ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Non-monosynaptic group I and group II excitation of human lower limb motoneurones was investigated. Changes in the firing probability of individual voluntarily activated motor units belonging to various muscles (soleus, gastrocnemius medialis, tibialis anterior, peroneus brevis, quadriceps and biceps femoris) were investigated after stimulation of various nerves (posterior tibial, common peroneal and femoral nerves) with weak (0.4–0.6×motor threshold) electrical stimuli. In all investigated motor nuclei, stimulation of the ”homonymous” nerve evoked a peak of increased firing probability with a latency that was 3–7 ms longer than the monosynaptic Ia latency. The more caudal the motor nucleus explored, the greater the central delay. This strongly suggests a transmission through neurones located above the lumbar enlargement. If one excepts the sural-induced excitation of peroneus brevis units, which seems to be mediated through a particular pathway, the main peripheral input to neurones mediating non-monosynaptic excitation evoked by these weak stimuli is group I in origin. The pattern of distribution of non-monosynaptic group I excitation was very diffuse, since stimulation of each nerve was able to evoke excitation in all investigated nuclei. In most cases, non-monosynaptic excitation evoked in a given motor unit by stimulation of one nerve was depressed on combined stimulation of two nerves, and evidence is presented that this lateral inhibition is exerted at a premotoneuronal level. By contrast, there was no evidence that increasing the afferent input in a given pathway evokes an ”autogenetic” inhibition in this pathway. The negative correlation found between non-monosynaptic group I-induced and late group II-induced facilitation of the quadriceps H-reflex when using high stimulus intensities applied on the common peroneal nerve suggests that these two effects could be mediated through common interneurones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005683
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  • 6
    Electronic Resource
    Electronic Resource
    New strategy for the characterization of amino acids by thin-layer electrophoresis and thin-layer chromatography using acidic mobile phases
    Amsterdam : Elsevier
    Analytical Biochemistry 100 (1979), S. 254-259 
    Details
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(79)90227-6
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  • 7
    Electronic Resource
    Electronic Resource
    Major surgery in a severe haemophilia A patient with high titre inhibitor: use of the thrombin generation test in the therapeutic decision (2005)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 11 (2005), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  In haemophilia patients with inhibitor, elective orthopaedic surgery is usually performed under recombinant activated factor VII (rFVIIa). We report here the case of a severe haemophilia A patient with a high inhibitor who needed a bilateral total knee arthroplasty. Recombinant FVIIa was previously shown to be ineffective for the treatment of muscle and joint bleedings, and he had a history of excessive postoperative bleeding under activated prothrombin complex concentrate (APCC). Thrombin generation test (TGT) was used to assess the efficacy of Factor Eight Inhibitor Bypassing Activity (FEIBATM). Insufficient correction of thrombin-generating capacity was observed after administration of 75 U kg−1 FEIBATM. In a multidisciplinary environment, a bilateral total knee arthroplasty was performed using a protocol combining immunoadsorption of inhibitors preoperatively associated with FVIII replacement during a first phase followed by FEIBATM when the inhibitor reappeared. To our knowledge this is the first direct application of TGT in the management of haemophilia patients with inhibitor, which indicated that a sequential use of immunoadsorption, FVIII and FEIBATM was the most appropriate treatment to perform this major elective surgery. This case demonstrates that this combined protocol can be safely used to cover major surgery in inhibitor patients. In addition, it also suggests that TGT may have a major contribution in the decision-making process of the most adapted therapy for the treatment of such high-risk patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2005.01141.x
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  • 8
    Electronic Resource
    Electronic Resource
    Haemophilia and thrombophilia: an unexpected association! (2004)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 10 (2004), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  In patients with haemophilia, a close correlation is usually observed between the clinical expression of the disease and plasmatic factor VIII/factor IX clotting activity. However, some patients experience milder bleeding phenotypes than others, although they exhibit a similar biological profile. The high prevalence of some inherited thrombophilia risk factors offers the possibility of a co-inheritance in haemophilic patients which could influence the phenotypic expression of the disease. Rare thrombotic complications occurring in haemophiliacs could also be facilitated by the co-inheritance of modifier genes. The majority of thrombotic events occurring in haemophiliacs are in relation to clotting factor infusions or central venous catheters. Concerning surgical situations, in the absence of therapeutic recommendations, postoperative thromboprophylaxis is not systematically performed in haemophiliacs. However, substitutive treatment more or less completely corrects the coagulation defect and makes the venous thrombosis risk closer to the control population. It should be emphasized that haemophilia does not fully protect against venous thromboembolic disease. Patients with haemophilia very infrequently experience thrombotic events. Thus, the management of thrombotic complications occurring in haemophilic patients should be discussed in each case according to the precipitating risk factors, the clinical context and the thrombo-haemorrhagic balance of the patient with respect to a particular clinical situation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2004.00906.x
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of rat plasma high density lipoprotein with or without apolipoprotein E on the cholesterol uptake and on the induction of the corticosteroid biosynthetic pathway in newborn rat adrenocortical cell cultures
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 1094 (1991), S. 153-160 
    Details
    ISSN: 0167-4889
    Keywords: (Rat adrenal cell) ; Cholesterol uptake ; Corticosteroid synthesis ; HDL subfraction
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0167-4889(91)90003-G
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  • 10
    Electronic Resource
    Electronic Resource
    Pattern of monosynaptic heteronymous Ia connections in the human lower limb (1993)
    Springer
    Experimental brain research 96 (1993), S. 534-544 
    Details
    ISSN: 1432-1106
    Keywords: Ia EPSP ; Monosynaptic Ia pathways ; Spinal reflexes ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Changes in the firing probability of single motor units in response to electrical stimulation of muscle nerves were used to derive the projections of muscle spindle Ia afferents to the motoneurones of various leg and thigh muscles. Discharges of units in soleus, gastrocnemius medialis, peroneus brevis, tibialis anterior, quadriceps, biceps femoris and semitendinosus were investigated after stimulation of inferior soleus, gastrocnemius medialis, superficial peroneal, deep peroneal and femoral nerves. Homonymous facilitation, occurring at the same latency as the H reflex and therefore attributed to monosynaptic Ia EPSPs, was found in virtually all the sampled units. In many motor nuclei an early facilitation was also evoked by heteronymous low-threshold afferents. The heteronymous facilitation was considered to be mediated through a monosynaptic pathway when the difference between the central latencies of heteronymous and homonymous peaks was not more than 0.2 ms. The heteronymous Ia connections were widely distributed. In particular, monosynaptic coupling between muscles operating at different joints appears to be the rule in humans, though it is rare between ankle and knee muscles in the cat and the baboon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234121
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