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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical studies of complement receptor (CR1) in cases with normal sinus mucosa and chronic sinusitis (1988)
    Springer
    European archives of oto-rhino-laryngology and head & neck 244 (1988), S. 350-354 
    Details
    ISSN: 1434-4726
    Keywords: Complement receptor ; Maxillary mucosa ; Peroxidase-antiperoxidase ; Avidin-biotin peroxidase ; Immunofluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The complement receptor (CR1) in the maxillary sinus mucosa of normal patients and in cases of chronic sinusitis was studied with the peroxidase-antiperoxidase, avidin-biotin peroxidase and immunofluorescent methods. CR1 was localized on the ciliary surface and in the cytoplasm of the covering epithelium in both normal controls and the cases of chronic sinusitis. CR1 tended to be denser in the mucosa of chronic sinusitis than in normal mucosa. CR1-binding capacity was also studied with the immunofluorescent method, using C3b-conjugated zymosan. Although CR1 did not bind to C3b in vivo, it was found to bind to C3b in the normal maxillary mucosa when it was treated with C3b-conjugated zymosan. CR1-binding capacity could not be detected in the mucosa from cases with chronic sinusitis, indicating that CR1 was already bound to activated C3b in these cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00497463
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Na/K-ATPase in rabbit paranasal sinus mucosa during induced sinusitis (1990)
    Springer
    European archives of oto-rhino-laryngology and head & neck 248 (1990), S. 119-122 
    Details
    ISSN: 1434-4726
    Keywords: Experimental sinusitis ; Rabbit ; Cytochemistry ; Na/K-ATPase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sinusitis was produced in rabbits, after which animals were separated into three groups: allergic sinusitis, induced purulent sinusitis, and spontaneous purulent sinusitis. Mucosal specimens were taken from these animals and normal controls. Na/K-ATPase was localized cytochemically and its activity studied in order to define the energy metabolism of secretion. The Na/K-ATPase reaction was unable to be clearly distinguished in either the allergic sinusitis specimens or the normal mucosa. In both purulent sinusitis groups, an intensive reaction was observed in the subepithelial glands and a weak reaction was found in the goblet cells. The Na/K-ATPase activity in the purulent sinusitis groups was significantly higher than that in the normal control group. The increased Na/K-ATPase activity may be an affect of hyperactivity of the secretory cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00240234
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Prognostic significance of epidermal growth factor receptor in squamous cell carcinoma of the maxillary sinus (1993)
    Springer
    European archives of oto-rhino-laryngology and head & neck 249 (1993), S. 478-481 
    Details
    ISSN: 1434-4726
    Keywords: Maxillary sinus ; Squamous cell carcinoma ; Epidermal growth factor receptor ; Local recurrence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The expression of epidermal growth factor receptor (EGFR) was determined immunohistochemically in two groups of maxillary sinus squamous cell carcinomas, one with recurrences at the primary site after combination therapy with radiotherapy, chemotherapy and/or surgery and one without local recurrences. Using a four-graded scale (-,+,++,+++), 9 of the 10 recurrent carcinomas had a staining intensity and proportion of stained cells of ++ or more. A comparable staining intensity was found in 9 of the 18 non-recurrent carcinomas. This difference is statistically significant (Fisher's exact probability test, P 〈 0.05). These results indicate that an increased expression of EGFR may influence the recurrence rate of squamous cell carcinoma of the maxillary sinus after combined therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168859
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A correlation of argyrophilic nucleolar organizer regions with prognoses in patients with maxillary sinus squamous cell carcinoma (1994)
    Springer
    European archives of oto-rhino-laryngology and head & neck 251 (1994), S. 229-232 
    Details
    ISSN: 1434-4726
    Keywords: Cell argyrophilic nucleolar organizer region ; Maxillary sinus carcinoma ; Local recurrence ; Metastasis ; Epidermal growth factor receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Argyrophilic nucleolar organizer regions (AgNORs) were determined by a semiautomatic image analyzer in a group of 28 patients with T2 or T3 maxillary sinus squamous cell carcinoma. The group was separated into recurrent and non-recurrent groups, metastatic and nonmetastatic groups, as well as groups strongly or weakly positive for epidermal growth factor receptor (EGFR). The mean number and area of AgNOR dots per nucleus and the mean size of each dot were calculated. The mean number and area were significantly greater than those in normal cells (P 〈 0.001), but not in recurrent and non-recurrent groups, metastatic and non-metastatic groups and groups separated by EGFR. There was also no difference found in the mean sizes of tumor and normal cells. These results suggest that AgNOR is related to malignant transformation, but not prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00628429
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    Paper (German National Licenses)
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