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Tuftsin-mediated immunoprophylaxis against an isolate of Aspergillus fumigatus shows less in vivo susceptibility to amphotericin B (2005)

Khan, Masood A. ; Ahmad, Nadeem ; Moin, Shagufta ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

FEMS immunology and medical microbiology 44 (2005), S. 0

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ISSN: 1574-695X

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology , Medicine

Notes: In the present study, we evaluated the immunopotentiating efficacy of tuftsin against experimental murine aspergillosis in both normal and immunodebilitant BALB/c mice. The animals were challenged with an isolate of Aspergillus fumigatus (1 ×108 cfu/mouse) that was showing less susceptibility to lower doses of amphotericin B in murine animal model. Co-administration of the immunomodulator tuftsin and liposomised-amphotericin B was found to be highly effective in the treatment of systemic infection of A. fumigatus in both immunocompetent and leukopenic mice. Moreover, pre-treatment of mice with liposomised-tuftsin prior to challenging them with A. fumigatus infection and subsequent treatment with tuftsin-bearing liposomised-amphotericin B was found to be extremely efficient in successful elimination of fungal pathogen. In another set of experiments, tuftsin-mediated antigen-specific memory antibody response was also assessed by immunizing the animals with A. fumigatus cytosolic antigen. The animals that received a booster 150 days after the first immunization with tuftsin–liposomes–antigen showed more resistance to A. fumigatus infection in comparison with the naïve animals.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/j.femsim.2004.12.013

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Erythrocytes from healthy smokers bind more bilirubin than the erythrocytes from healthy non-smokers (1998)

Moin, Shagufta ; Kutub Ali, Mohammad ; Ullah Siddiqui, Mashiat ; [et al.]

Springer

Molecular and cellular biochemistry 183 (1998), S. 211-214

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ISSN: 1573-4919

Keywords: bilrubin ; human erythrocytes ; non-smoker ; smoker

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Abstract Cigarette smoking is an adverse prognostic factor for health. Its damaging effects on many enzymatic and cellular activities are well known. The present study was carried out to evaluate whether there is a difference in the binding of bilirubin to the erythrocytes from healthy smokers and non-smokers. The results suggest that the binding of bilirubin to the erythrocytes from healthy smokers as well as in vitro smoked erythrocytes is significantly higher than that of healthy non-smokers.