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  • 1
    Electronic Resource
    Electronic Resource
    Phosphorus-32 postlabeling measurement of adenine N-1-oxide in cellular DNA exposed to hydrogen peroxide (1990)
    s.l. : American Chemical Society
    Chemical research in toxicology 3 (1990), S. 102-110 
    Details
    ISSN: 1520-5010
    Source: ACS Legacy Archives
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/tx00014a004
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chemical and biochemical postlabeling methods for singling out specific oxidative DNA lesions
    Amsterdam : Elsevier
    Mutation Research DNAging 275 (1992), S. 343-354 
    Details
    ISSN: 0921-8734
    Keywords: DNA base damage ; Fluorescent labeling ; Measurement of DNA lesions ; Oxidised sugar residues ; Radioisotope postlabeling
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-8734(92)90037-P
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  • 3
    Electronic Resource
    Electronic Resource
    Purification of DNA and group separation of normal and modified DNA components by size-exclusion chromatography
    Amsterdam : Elsevier
    Journal of Chromatography A 539 (1991), S. 373-381 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(01)83946-7
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  • 4
    Electronic Resource
    Electronic Resource
    Handbook of behavioral neurobiology. Vol. 4. Biological rhythms - Jurgen Aschoff. Plenum Press, New York, 1981. ISBN 0-306-40585-7. Price not given.
    Amsterdam : Elsevier
    Neuropsychologia 21 (1983), S. 117 
    Details
    ISSN: 0028-3932
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0028-3932(83)90107-0
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  • 5
    Electronic Resource
    Electronic Resource
    Sleep disturbance due to transportation noise: ear plugs vs oral drugs (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 429-437 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Conclusion Sleep is not only the output of an EEG machine but a global phenomenon with unique physiological, environmental and psychological features occurring in a given individual. There is no question that statistical evaluation of noise-induced sleep disturbances in non homogeneous groups of subjects has resulted in the construction of a magnificent neurophysiological edifice by assembling a few individual bricks. In this respect, whether subjectively disturbed or not, we now know that when we sleep in noisy areas our delta sleep is reduced, our heart rate fails to habituate to individual noises, and we are more likely to develop psychic disturbances than residents in quiet areas. Data from these studies are however interspersed with results from a number of experiments during which the subject has been looked upon as nothing but a sleeper, i.e., experiments in which day-time stresses and noises were considered as irrelevant for the night-time study. It seems important therefore that future studies should gather more longitudinal data based on a limited number of subjects selected according to their day-time habits and psychological (e.g., extroverts/introverts) and physiological (e.g., short or long sleepers) characteristics. The knowledge about these situational factors and personality traits might provide new insights into individual biological strategies developed to cope with noise stress. The difficulties in assessing the effect of noise on sleep are particularly obvious if we consider another finding: deaf subjects spend significantly less time in delta sleep than do control subjects47 and they present sleep pattern alterations remarkably similar to those which are most consistently described in noisy conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952377
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of trazodone on the sleep of depressed subjects — a polygraphic study (1988)
    Springer
    Psychopharmacology 95 (1988), S. S37 
    Details
    ISSN: 1432-2072
    Keywords: Trazodone ; Antidepressant ; Polygraphic sleep recordings ; Plasma levels ; Refractory depression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of 400–600 mg trazodone on the sleep patterns of ten depressed in-patients treated for 5 weeks were studied during the initial (days 1–3) and terminal (days 26–28) treatment periods. The sleep parameters were compared to those obtained from three sleep recordings performed just prior to the initiation of the treatment and after 2 adaptation nights at the end of a 2-week drug-free period. At the same time, the clinical evolution of patients was evaluated weekly using MADRS and Hamilton-Anxiety scales for anxiety-depression symptomatology and Spiegel and Norris sleep scales. Weekly blood samples were collected to measure plasma levels of trazodone and, at the end of the study, the elimination half-life at steady state was calculated by repeated measurements of plasma levels. Clinical improvement, as assessed by a reduction of more than 60% in MADRS scale scores, was accompanied by evidence of the definitely beneficial effects of trazodone on the disturbed sleep of these depressed patients. From the beginning of treatment, there was a hypnotic-like effect (increase in total duration of sleep and stage II, decrease in sleep latency and intrasleep awakenings). In addition, records at the end of the study showed an increase in delta sleep and an increase in REM latency, an effect classically associated with an antidepressant action. These particularly valuable effects of trazodone on sleep would suggest that this drug should especially be given in cases of depression with major insomnia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172629
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  • 7
    Electronic Resource
    Electronic Resource
    Monoaminmetabolite und zyklische Nukleotide des Liquor cerebrospinalis bei Wismut- und Quecksilber-Encephalopathien (1978)
    Springer
    European archives of psychiatry and clinical neuroscience 226 (1978), S. 173-181 
    Details
    ISSN: 1433-8491
    Keywords: Bismuth ; Mercury ; Encephalopathy ; Cyclic nucleotides ; Monoamines ; Probenecid ; Cerebrospinal fluid ; Wismut ; Quecksilber ; Enzephalopathie ; Zyklische Nukleotide ; Monoamine ; Probenezid ; Liquor cerebrospinalis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei drei Patienten mit akuter Wismutenzephalopathie und einem Patienten mit chronischer Quecksilberenzephalopathie wurden die Monoaminmetaboliten Homovanillinsäure (HVS) und 5-Hydroxy-Indolessigsäure (5-HIES) sowie die zyklischen Nukleotide cAMP und cGMP im Liquor cerebrospinalis vor und nach Probenecid-Belastung bestimmt. Bei den Patienten mit Wismutenzephalopathie ergaben sich Hinweise auf Änderungen des Dopamin und des cGMP-Stoffwechsels in Korrelation zum klinischen Schweregrad. Der Anstieg von HVS und von cGMP war im akuten Stadium der schweren Hyposomnie gehemmt und bei einem Patienten in der Rückbildungsphase vermehrt. Bei dem Patienten mit chronischer Hg-Vergiftung war die Akkumulation von HVS fast völlig aufgehoben bei vermehrtem Anstieg von cGMP. Keine eindeutigen Änderungen waren im Verhalten des Serotoninmetaboliten 5-HIES und des cAMP erkennbar. Es wird geschlossen, daß bei Wismut und Quecksilberenzephalopathie der Stoffwechsel von Dopamin und von cGMP im Hirnstamm und im Kleinhirn gestört ist.
    Notes: Summary The central metabolism of dopamine, serotonin, cyclic AMP and cyclic GMP was studied by use of the probenecid test in three patients with bismuth encephalopathy and in one patient with mercury encephalopathy. The accumulation of HVA and of cGMP in the cerebrospinal fluid was depressed during the acute phase of bismuth encephalopathy with severe hyposomnia, while it was increased in a patient with regression of clinical symptoms and normal in a patient with more advanced recovery. The patient with chronic mercury poisoning showing a severe cerebellar ataxia and rigidity had an almost complete suppression of HVA accumulation and an increase of cGMP accumulation. No pronounced differences of 5-HIAA and cAMP behavior were found. It is concluded that the central metabolism of dopamine and of cGMP is severely affected in bismuth and mercury encephalopathies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341709
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