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  • 1
    Electronic Resource
    Electronic Resource
    Turret exostosis of the phalanges presenting as limited motion of the finger (2000)
    Springer
    European journal of plastic surgery 23 (2000), S. 82-84 
    Details
    ISSN: 1435-0130
    Keywords: Key words Hand ; Osteochondroma ; Turret exostosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Turret exostosis, or acquired osteochondroma, was first described by Wissinger et al. as a subperiosteal bone formation which develops beneath the extensor apparatus It shares common clinical and radiological features with florid reactive periostitis and bizarre periosteal osteochondromatous proliferation (Nora’s lesion) which belong to the same group of reactive lesions of the bone surface. Turret exostosis is a rare complication of a minor injury to the hand. Its peak incidence is in the third and fourth decades of life, predominantly affecting the proximal and middle phalanges of the hand. Metacarpal involvement has also been reported. It is characterized by pain, soft tissue swelling and a growing mass leading to limitation of motion and cosmetic deformity. This is a report of seven patients in whom lump formation and limitation of motion were the presenting symptoms of turret exostosis. The literature is reviewed and the possible pathogenesis of this disorder is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002380050020
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  • 2
    Electronic Resource
    Electronic Resource
    A quantitative cytochemical method for the measurement of β-hydroxyacyl CoA dehydrogenase activity in rat heart muscle (1982)
    Springer
    Histochemistry and cell biology 75 (1982), S. 67-76 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Although cytochemical methods exist for measuring dehydrogenases that act on substrates involved in the production of chemical energy from sugars, virtually no methods exist for measuring the dehydrogenases that act on fatty acids. Yet the oxidation of fatty acids accounts for over 60% of the oxidative activity of cardiac muscle. Consequently a new quantitative cytochemical method, based on a new substrate (DL-S-β-hydroxybutyryl-N-acetyl cysteamine), has been developed for measuring the activity of hydroxy-acyl coenzyme A dehydrogenase, which is the penultimate step of the β-oxidation of fatty acids to acetyl-coenzyme A that is used in the Krebs' cycle. Menadione or phenazine methosulphate is used as the intermediate hydrogen-acceptor, with neotetrazolium chloride as the final acceptor. The medium contains nitroprusside, ostensibly to react with any cysteamine liberated by hydrolysis of the substrate. As a control, cysteamine is substituted for the substrate. The concentrations of reactants have been optimized for cardiac muscle; the reaction is linear with thickness of the sections and with time of reaction from 15 to 60 min.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00492534
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Inflammatory Bowel Disease and Myositis (1999)
    Springer
    Clinical rheumatology 18 (1999), S. 261-263 
    Details
    ISSN: 1434-9949
    Keywords: Key words:Crohn’s – IBD – Myositis – Ulcerative colitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: A patient with Crohn’s disease developed proximal muscle weakness, increased serum creatine phosphokinase activity and electromyographic abnormalities. A muscle biopsy was non-diagnostic. Although rare, myositis should be included in the differential diagnosis of muscle weakness in patients with inflammatory bowel disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100670050097
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  • 4
    Electronic Resource
    Electronic Resource
    Naproxen-Induced Leukocytoclastic Vasculitis (2000)
    Springer
    Clinical rheumatology 19 (2000), S. 242-244 
    Details
    ISSN: 1434-9949
    Keywords: Key words:Leukocytoclastic – Naproxen – Vasculitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Cutaneous reactions to non-steroidal anti-inflammatory drugs (NSAIDs) are rare in spite of their wide use. Only a few cases of hypersensitivity angiitis related to naproxen have been described. We report the case of a 62-year-old woman in whom leukocytoclastic skin vasculitis, peripheral neuropathy and nephritis developed after a short naproxen treatment, and gradually regressed after discontinuation of the drug and under glucocorticoid therapy. In the light of the relevant literature, the clinical and laboratory features of this reversible condition are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100670050167
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  • 5
    Electronic Resource
    Electronic Resource
    Aerobic glycolysis of bone and cartilage: The possible involvement of fatty acid oxidation (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Cell Biochemistry and Function 1 (1983), S. 168-172 
    Details
    ISSN: 0263-6484
    Keywords: Bone ; aerobic glycolysis ; fatty acid oxidation ; cartilage ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The apparent paradox of aerobic glycolysis has been investigated in bone and in cartilage. A new cytochemical procedure for hydroxyacyl dehydrogenase (HOAD) activity showed that the maximal activity of this enzyme in both tissues was equivalent to the maximal activity of glyceraldehyde 3-phosphate dehydrogenase (GAPD). The sum of these activities gave a measure of the maximum amount of acetyl-coenzyme A that could be produced. In these tissues, but not in liver which does not exhibit aerobic glycolysis, this summed value exceeded the maximal activity of succinate dehydrogenase (SDH). Consequently, it suggested that where fatty acid oxidation is sufficient to supply all the acetyl-coenzyme A required for the Krebs' cycle, that derived from fatty acid oxidation may inhibit pyruvate dehydrogenase causing accumulation of pyruvate which must be converted to lactate if pentose-shunt activity is to be maintained.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cbf.290010309
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Evidence for a differential distribution of reducing equivalents from NADPH in cartilage (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Cell Biochemistry and Function 7 (1989), S. 301-303 
    Details
    ISSN: 0263-6484
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: It has been suggested that the NADPH, generated from the activity of glucose 6-phosphate dehydrogenase, may be utilized by two different routes, namely either for biosynthetic purposes (type 2) or for microsomal respiration (type 1). This concept has been tested in the rabbit ear model in which an injection of papain into the rabbit causes loss of proteoglycans of the auricular matrix followed by its restoration over the following eight days. It is shown that whereas the type 1 pathway was either unaltered or diminished, the doubling of the glucose 6-phosphate dehydrogenase activity was related solely to the type 2 pathway.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cbf.290070409
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  • 7
    Electronic Resource
    Electronic Resource
    Aerobic glycolysis: A study of human articular cartilage (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Cell Biochemistry and Function 5 (1987), S. 109-112 
    Details
    ISSN: 0263-6484
    Keywords: Human articular cartilage ; aerobic glycolysis ; quantitative cytochemistry ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Cartilage generally is one of those tissues that exhibit aerobic glycolysis. In a previous study on rat epiphyseal cartilage it had been suggested that this phenomenon is related to potentially excessive production of pyruvate and acetyl coenzyme A, the latter derived from fatty acid oxidation and inhibiting pyruvate dehydrogenase activity. The present study has shown that, in human articular cartilage, the contribution from fatty acid oxidation is too small to account for this phenomenon although the total potential production of pyruvate could still be in excess of the requirements for acetyl coenzyme A for the Krebs' cycle. Of greater relevance may be the apparent correlations that have been found between the activities of lactate and glyceraldehyde 3-phosphate dehydrogenases (r = 0·82: 0·01 〉 p 〉 0·001) and between those of lactate and glucose 6-phosphate dehydrogenases (r = 0·92; p 〈 0·001).
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cbf.290050205
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  • 8
    Electronic Resource
    Electronic Resource
    Peculiar ultraviolet absorbing moieties of human osteoarthritic cartilage (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Cell Biochemistry and Function 8 (1990), S. 131-135 
    Details
    ISSN: 0263-6484
    Keywords: Osteoarthritis ; microspectrophotometry ; human articular cartilage ; ultraviolet absorption ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The ultraviolet absorbing components of human cartilage have been measured by microspectrophotometry. The characteristics of the chondrocytes appeared to be identical, irrespective of the pathology. However the matrix of osteoarthritic cartilage contained components that absorbed maximally in the region of 270 to 250 nm; such components were not found in the matrix of cartilage of non-arthritic joints. Substances that absorb maximally in this region of the ultraviolet could generate free radicals.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cbf.290080207
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  • 9
    Electronic Resource
    Electronic Resource
    Altered orientation of glycosaminoglycans and cellular changes in the tibial cartilage in the first two weeks of experimental canine osteoarthritis (1985)
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 3 (1985), S. 258-268 
    Details
    ISSN: 0736-0266
    Keywords: Experimental osteoarthritis ; Polarized light microscopy ; Orientation of glycosaminoglycans ; Water content ; Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Changes in the cellularity and in the nature of the matrix were studied in the cartilages of the tibial plateau in experimentally induced arthritis in the dog, 7 and 14 days after section of the anterior cruciate ligament. Samples from the different regions of these cartilages were chilled and sectioned in a cryostat, with a variable microtome chuck to allow precise orientation of the specimens. The samples were examined by normal light microscopy, by microscopic interferometry, and by quantitative polarized light microscopy. The orientation of the glycosaminoglycans was assessed by the new “induced birefringence” method. The results indicated that only the region of the medial tibial cartilage that was unprotected by the meniscus was affected, showing increased water content, loss of superfical cells, and a decrease in orientation of the glycosaminoglycans. Whereas the birefringence of the collagen was markedly increased: this may be a useful indicator of early osteoarthritic changes.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jor.1100030302
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