ISSN:
1432-0584
Keywords:
Key words Steroid pulse therapy
;
Methylprednisolone
;
Low-titer cold-hemagglutinin disease
;
Childhood
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We report the case of a 12-year-old boy suffering from severe low-titer cold-hemagglutinin disease with excruciating colicky abdominal pain, jaundice, and acute hemolytic anemia requiring transfusion. Cold hemagglutinins of the IgM type and a positive direct antiglobulin test, predominantly against C3d, were found. Steroid pulse therapy with 20 mg/kg body wt. methylprednisolone for 3 consecutive days was given. Abdominal pain disappeared within 12 h of the first steroid infusion and hemolysis was halted. We conclude that a therapeutic trial with steroid pulse therapy in severe low-titer cold-hemagglutinin disease is warranted.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01699254
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