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  • 1
    Electronic Resource
    Electronic Resource
    Results of selective screening for inborn errors of metabolism in the former East Germany (1994)
    Springer
    European journal of pediatrics 153 (1994), S. S14 
    Details
    ISSN: 1432-1076
    Keywords: Key words: Hereditary metabolic disorders – Selective screening – Collaborative study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Since the early 1970s selective screening for inherited metabolic disorders has been performed in larger childrens hospitals or metabolic centres of the former East-Germany. As a rule the following methods were employed: initially paper chromatography, drop, dip and spot tests, later on thin-layer chromatography and more recently enzyme analysis, gas chromatography, mass spectrometry and HPLC. Normally urine, blood or leucocytes were investigated. The diagnoses were confirmed in metabolic centres in Greifswald, Berlin or Leipzig or in collaboration with specialized laboratories abroad. About 130 000 subjects from former East Germany as well as from different East European countries were investigated, of which 365 patients were diagnosed and classified into roughly 40 various metabolic diseases. The proportion of positive diagnoses was 1 in 400.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02138771
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Results of selective screening for inborn errors of metabolism in the former East Germany (1994)
    Springer
    European journal of pediatrics 153 (1994), S. S14 
    Details
    ISSN: 1432-1076
    Keywords: Hereditary metabolic disorders ; Selective screening ; Collaborative study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since the early 1970s selective screening for inherited metabolic disorders has been performed in larger childrens hospitals or metabolic centres of the former East-Germany. As a rule the following methods were employed: initially paper chromatography, drop, dip and spot tests, later on thin-layer chromatography and more recently enzyme analysis, gas chromatography, mass spectrometry and HPLC. Normally urine, blood or leucocytes were investigated. The diagnoses were confirmed in metabolic centres in Greifswald, Berlin or Leipzig or in collaboration with specialized laboratories abroad. About 130000 subjects from former East Germany as well as from different East European countries were investigated, of which 365 patients were diagnosed and classified into roughly 40 various metabolic diseases. The proportion of positive diagnoses was 1 in 400.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02138771
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Inducibility of cytochrome P-450 in Acinetobacter calcoaceticus by n-alkanes (1984)
    Springer
    Applied microbiology and biotechnology 19 (1984), S. 398-403 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Cytochrome P-450, detectable in n-hexadecane-grown cells of Acinetobacter calcoaceticus, is not found during growth on complex media, sugars, or various metabolic indermediates, such as mono- or dicarboxylic acids. Cytochrome P-450 formation is observed after shifting cells from a non-hydrocarbon medium to a minimal medium with n-hexadecane as the sole source of carbon, or after addition of n-hexadecane to cultures growing on a non-inducing carbon source. The content increases with time. Induction of cytochrome P-450 is inhibited by streptomycin, chloramphenicol, and rifampicin. Besides n-hexane, other n-alkanes from n-hexane up to n-hexadecane are inducers, whereas cetyl alcohol or palmitic acid are not. The results indicate that the occurrence of cytochrome P-450 in n-alkane-induced cells reflects a de novo protein synthesis. Regulation seems not to be governed by catabolite repression but by the presence of an inducer molecule, which is either an n-alkane or a very similar molecule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454377
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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