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  • 1
    Electronic Resource
    Electronic Resource
    A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth (1995)
    [s.l.] : Nature Publishing Group
    Nature medicine 1 (1995), S. 528-533 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Expression of the RIα subunit of cAMP-dependent protein kinase type I is enhanced in human cancer cell lines, in primary tumours, in cells after transformation and in cells upon stimulation of growth. We have investigated the effect of sequence-specific inhibition of RIα gene expression ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0695-528
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of the regulatory subunit of cAMP-dependent protein kinase on the genetic activity of eukaryotic cells (1982)
    Springer
    Molecular and cellular biochemistry 49 (1982), S. 53-61 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of the regulatory subunit of cAMP-dependent protein kinase from pig brain on the protein synthesis in normal (3T3) and virus-transformed (SV40-3T3) cells was studied. The regulatory subunit was found to induce a specific synthesis of new proteins; the direct and first response of 3T3 cells to the introduction of the regulatory subunit being the synthesis of the protein P-15. The molecular weight of the protein was 15 000, the isoelectric point 6.3. The electrophoretic analysis of the cytosol of SV40-3T3 cells demonstrated a general derepression of the genome of the virus-transformed cells. A protein identical with P-15 was detected to be present in SV40-3T3 cells. The treatment of these cells with the regulatory subunit as well as with cAM P separately did not affect the synthesis of P-15, whereas the introduction of the cAM P-regulatory subunit complex caused a significant expression of the protein P-15. The data obtained indicate that the protein synthesis is dependent on the nuclear translocation of the regulatory subunit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230996
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth (2000)
    Springer
    Molecular and cellular biochemistry 212 (2000), S. 29-34 
    Details
    ISSN: 1573-4919
    Keywords: cAMP ; transcription factor-decoy oligonucleotides ; CRE ; Ap-1 ; p53 ; tumor growth ; gene expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Nucleic acid molecules with high affinities for a target transcription factor can be introduced into cells as decoy cis-elements to bind these factors and alter gene expression. This review discusses a synthetic single-stranded palindromic oligonucleotide, which self-hybridizes to form a duplex/hairpin and competes with cAMP response element (CRE) enhancers for binding transcription factors. This oligonucleotide inhibits CRE- and Ap-1-directed gene transcription and promotes growth inhibition in vitro and in vivo in a broad spectrum of cancer cells, without adversely affecting normal cell growth. Evidence presented here suggests that the CRE-decoy oligonucleotide can provide a powerful new means of combating cancers, viral diseases, and other pathological conditions by regulating the expression of cAMP-responsive genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007144618589
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of a specific histone kinase on the physico-chemical properties of chromatin In situ (1975)
    Springer
    Molecular biology reports 2 (1975), S. 241-245 
    Details
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The influence of a specific histone kinase, phosphorylating lysine-rich histone F1, F2a2, F2b, on the physico-chemical properties of the chromatin in the whole undestroyed fixed cell, has been investigated. It was found that the exogenous histone kinase penetrates into the nuclei of the undestroyed fixed cells and into the isolated unfixed nuclei and changes the physico-chemical properties of the chromatin there, bringing about an increase in binding of a basic dye acridine orange and a decrease in its stability to heat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00356994
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    Paper (German National Licenses)
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