ISSN:
1432-1920
Keywords:
Key words Brain
;
basal ganglia
;
Pituitary gland
;
Manganese
;
Parenteral nutrition
;
Magnetic resonance imaging
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Hypermanganesaemia is reported in patients on long-term parenteral nutrition. Deposition of manganese, giving high signal on T1-weighted images, may involve the basal ganglia. MRI in nine patients (mean age 51 years, range 31–75 years) on long-term parenteral nutrition (mean duration 30 months, range 6–126 months), demonstrated high signal in the anterior pituitary gland on T1-weighted sagittal and coronal images. The gland appeared normal on T2-weighted images. Signal intensity in the basal ganglia on T1-weighted images was increased in all patients. Endocrine assessment showed no significant abnormality. Neurological examination showed a mild parkinsonian movement disorder in one patient. Hypermanganaesemia was present in all nine (1.3–2.8 μmol/l, mean 1.87 μmol/l). The high signal in the anterior pituitary gland was probably related to deposition of paramagnetic substances, especially manganese.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002340050686
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