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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 45 (1993), S. 221-225 
    ISSN: 1432-1041
    Keywords: Primary biliary cirrhosis — Ursodeoxycholic acid therapy ; cholic acid ; α-dihydroxy bile salts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We treated 6 patients with Stage II primary biliary cirrhosis with cholic acid (CA) 10 mg · kg−1 per day for 3 months and then with the same dose of ursodeoxycholic acid (UDCA). A matching group of 6 patients was observed for 3 months without any therapy. Liver function tests and serum and stool bile acids were investigated before, during and at the end of CA and UDCA therapy. The results of liver function tests deteriorated after 6–8 weeks of CA therapy and the changes were correlated (r=0.92) with an increase in α-dihydroxy-bile acids (chenodeoxycholic acid and deoxycholic acid) in the serum. The 24 h excretion of DCA in 24 h faeces was markedly increased. Ursodeoxycholic acid treatment improved liver function tests; after 4 weeks glutamate dehydrogenase (GLDH) had decreased. After 8–12 weeks of therapy ursodeoxycholic acid had increased to 50–60% of the total serum bile acids whereas the more apolar bile acids were significantly decreased. No changes in liver function tests or bile acid metabolism were found in the untreated group. Since CA and UDCA are non-toxic in man, this trial indicates that the apolar bile acids chenodeoxycholic acid and deoxycholic acid may be responsible for the deterioration of liver function in primary biliary cirrhosis. However, the therapeutic effect of UDCA cannot be explained merely by the decrease in α-dihydroxy-bile acids in the serum, since the laboratory results had improved prior to the decrease in the serum apolar bile acids.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 367 (1974), S. 177-189 
    ISSN: 0005-2736
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 17 (1970), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A new modification is described for the fractionation of nucleic acids from brain. The cold phenol method followed by a hot extraction was combined with ‘salt-precipitation’ and chromatography on Sephadex and Agarose gels. The method enables the isolation of five highly purified fractions in large amounts: DNA; high molecular weight salt-soluble RNA, a hitherto undescribed fraction; rRNA; residual RNA (mRNA) and sRNA. All fractions showed, after 9 h in vivo incubation with 32P, different specific radioactivities and/or characteristic base compositions. The single mononucleotides of each RNA fraction differed markedly in their 32P-labelling rate. This was found to be a new characteristic, for these differences were in no way similar in the various RNAs, but specific and constant for each fraction. An assay of base composition only by 32P-labelling was therefore not possible.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 292 (2000), S. 366-368 
    ISSN: 1432-069X
    Keywords: Key words Melatonin ; Keratinocytes ; UVB protection ; Radical scavenger
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 69 (1997), S. 1330-1330 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 6 (1986), S. 55-62 
    ISSN: 0138-4988
    Keywords: Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: The production costs of ethanol are dependent on the efficiency of the substrate-ethanol conversion to a high degree. The more the substrate used during the fermentation is converted into alcohol the better is the economy of the process.Therefore the ethanol yield Y SP is an important object of the process optimization.In batch fermentation processes the most essential influence factors are the initial biomass concentration X0, the initial substrate concentration S0, the temperature T, and the pH-value.A model reflecting the complex relationships between these influence factors and the ethanol yield could be obtained by regression. It allows an exact valuation of these optimum process parameters which are necessary for realizing high ethanol yields in the batch fermentation.For the strain Saccharomyces cerevisiae Sc 5 used in this research was found an ethanol yield maximum YSP = 0·5384 at the parameters X0 = 64.61 g/l S0 = 82.91 g/l T = 36.45°C pH = 6.54.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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