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  • 1
    Electronic Resource
    Electronic Resource
    Pineal, Retinal, Serum Melatonin, and N-Acetylserotonin Rhythms in Chicks on Reversing Light Regimen Eye Covering (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 4 (1987), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: After reversing a 12:12-h light-dark regimen of environmental lighting, pineal retinal melatonin levels of white leghorn chicks recorded at the first mid-darkness were greatly enhanced reached maximum levels after three more days; those recorded during the light periods indicate gradual decline but were far from the nadir of the original light period, even at the end of the experiment.The first mid-darkness serum melatonin levels recorded after photoperiod reversal were not much different from their original mid-light values. However, on continuing with the reversed regimen, the next mid-darkness levels were sharply increased, maximum levels were reached after a further 2 days. Under the same experimental conditions light had much more drastic effects, 6 h on the reversed regimen were sufficient to bring down completely the high value of the original mid-darkness period to the level of the starting mid-light nadir.Retinal N-acetylserotonin (NAS) measured simultaneously had a pattern similar to that of melatonin, but the pineal NAS rhythm did invert completely, albeit gradually.Eye covering did not prevent inversion of pineal serum melatonin rhythms, which were identical in eye-covered sighted control chicks on the reversed regimen of light. However, retinal melatonin values of the light periods were significantly less depressed in eye-covered than in sighted control chicks. Moreover, eye covering completely prevented the retinal NAS depression under light but did not affect pineal NAS. During darkness retinal pineal NAS elevation was sluggish in the eye-covered chicks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.1987.tb00868.x
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  • 2
    Electronic Resource
    Electronic Resource
    Δ 1-tetrahydrocannabinol but not cannabidiol reduces contact and aggressive behavior of rats tested in dyadic encounters (1984)
    Springer
    Psychopharmacology 84 (1984), S. 561-565 
    Details
    ISSN: 1432-2072
    Keywords: Δ 1-Tetrahydrocannabinol (Δ 1-THC) ; Cannabidiol (CBD) ; Social behavior ; Social interactions ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A low and a high dose of Δ 1-Tetrahydrocannabinol (Δ 1-THC) and of cannabidiol (CBD) were IP injected in rats that had been isolated for 7 days. Forty-five minutes after injection, the rats were tested for social interactions with non-isolated, untreated test partners in dyadic encounters under standardized conditions. Different aspects of social behavior were analyzed. The high dose of Δ 1-THC (10 mg/kg) prevented nearly all social interactions. The low dose of Δ 1-THC (1 mg/kg) exerted selective and specific effects on social interactions. Social contact behavior, including crawl over/mounting, and social grooming, and aggressive behavior, including fighting, kicking, and biting, were markedly decreased, whereas social exploratory behavior (exploration of the partner and anogeniaal investigation) and the behavioral item, approach/follow, were hardly affected by Δ 1-THC treatment. Both doses of CBD (2 and 20 mg/kg) failed to change the various aspects of social interaction. It is postulated that the effects of Δ 1-THC on close and intimate contact behavior of rats may contribute to the understanding of marihuana taking in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431467
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Brief report: Circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism (1995)
    Springer
    Journal of autism and developmental disorders 25 (1995), S. 641-654 
    Details
    ISSN: 1573-3432
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract An abnormal circadian pattern of melatonin was found in a group of young adults with an extreme autism syndrome. Although not out of phase, the serum melatonin levels differed from normal in amplitude and mesor. Marginal changes in diurnal rhythms of serum TSH and possibly prolactin were also recorded. Subjects with seizures tended to have an abnormal pattern of melatonin correlated with EEG changes. In others, a parallel was evidenced between thyroid function and impairment in verbal communication. There appears to be a tendency for various types of neuroendocrinological abnormalities in autistics, and melatonin, as well as possibly TSH and perhaps prolactin, could serve as biochemical variables of the biological parameters of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02178193
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    Paper (German National Licenses)
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