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  • 1
    Electronic Resource
    Electronic Resource
    Effect of Y-24180, an antagonist at platelet-activating factor (PAF) receptors, on IgE-mediated cutaneous reactions in mice (1998)
    Springer
    Inflammation research 47 (1998), S. 506-511 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Y-24180 — PAF — Cutaneous reaction — IgE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: We examined the effect of Y-24180, a potent platelet-activating factor (PAF) antagonist, on IgE-mediated cutaneous reactions in mice.¶Materials: Female BALB/c mice were used.¶Treatment: Drugs were orally administered 1 h before a dinitrofluorobenzene (DNFB) challenge or 1 h before and 12 h after the challenge.¶Methods: Biphasic increase in ear thickness, with peak responses at 1 h (immediate phase reaction, IPR) and 24 h (late phase reaction, LPR) after the DNFB challenge, were induced in mice which had been passively sensitized with monoclonal anti-dinitrophenyl IgE antibody 24 h before the DNFB challenge. Ear thickness was measured with a dial thickness gauge.¶Results: Y-24180, WEB2086, ketotifen, and suplatast suppressed the IPR. Y-24180 also suppressed the LPR when administered once at 10 mg/kg or twice at 1 to 10 mg/kg. WEB2086 suppressed the LPR only when administered twice. However, ketotifen and suplatast did not suppress the LPR even when administered twice. Single administration of prednisolone significantly suppressed both the IPR and LPR.¶Conclusions: These results indicate that PAF may be involved in the induction of biphasic cutaneous reactions mediated by IgE, and Y-24180 is more effective compared with WEB2086 in this model. It is possible that the difference in the effectiveness between Y-24180 and WEB2086 depends on the persistence of those activities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050366
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of FTY720, a novel immunosuppressant, on adjuvant-induced arthritis in rats (2000)
    Springer
    Inflammation research 49 (2000), S. 404-410 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Adjuvant-induced arthritis - Peripheral lymphocyte - FTY720 - Cyclosporin A - Tracrolimus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Objective and Design: Anti-arthritic effect of FTY720, a novel immunosuppressant, was compared with those of immunosuppressants cyclosporin A and tacrolimus in adjuvant- induced arthritis in rats.¶Material: Male LEW rats.¶Treatment: FTY720 (0.03-0.3 mg/kg), cyclosporin A (1-10 mg/kg) or tacrolimus (0.3-3 mg/kg) were orally administered to rats for 21 days beginning on the day (day 0) of adjuvant inoculation. In addition, the anti-arthritic effect of FTY720 (0.3 mg/kg) and cyclosporin A (10 mg/kg) were evaluated by administration to animals for 5 consecutive days (days 2-6, 6-10, and 10-14).¶Methods: Adjuvant-induced arthritis was produced by intradermal injection of 0.5 mg heat-killed Mycobacterium tuberculosis. Hindpaw edema was measured plethysmographically. The day of arthritis onset was determined macroscopically. Bone degradation was determined by radiography. Peripheral blood leukocytes were classified microscopically.¶Results: All test compounds inhibited the incidence of arthritis, hindpaw edema and bone destruction. In addition, FTY720 but not cyclosporin A or tacrolimus markedly decreased the number of peripheral blood lymphocytes. FTY720 treatment on days 6 to 10 inhibited the bone destruction and hindpaw edema.¶Conclusion: These results suggest that the anti-arthritic ef-fect of FTY720 in this adjuvant-induced arthritic model was more potent than those of cyclosporin A and tacrolimus. FTY720 administered on days 6 to 10 showed the inhibitory effect on the bone destruction and hindpaw edema. FTY720 may be effective in the treatment of rheumatoid arthritis.¶
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050608
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  • 3
    Electronic Resource
    Electronic Resource
    Enantioselective synthesis of new analogs of neplanocin A and their biological activity
    Amsterdam : Elsevier
    Carbohydrate Research 171 (1987), S. 233-258 
    Details
    ISSN: 0008-6215
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0008-6215(00)90890-5
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  • 4
    Electronic Resource
    Electronic Resource
    Elemental mass spectrometry using a nitrogen microwave-induced plasma as an ion source
    Amsterdam : Elsevier
    Spectrochimica Acta Part B: Atomic Spectroscopy 49 (1994), S. 901-914 
    Details
    ISSN: 0584-8547
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0584-8547(94)80079-0
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  • 5
    Electronic Resource
    Electronic Resource
    Arginase as an inhibitory principle in liver plasma membranes arresting the growth of various mammalian cells in vitro
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 720 (1982), S. 188-192 
    Details
    ISSN: 0167-4889
    Keywords: Arginase ; Growth inhibition ; Plasma membrane
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4889(82)90011-8
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  • 6
    Electronic Resource
    Electronic Resource
    Activity of a novel carotenoid analog, 4,4′-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaen-1,18-diyl) bis(1-ethylpyridinium) dibromide (Y-18598) on mouse leukemia P388 (1985)
    Springer
    Journal of cancer research and clinical oncology 109 (1985), S. 257-259 
    Details
    ISSN: 1432-1335
    Keywords: A new carotenoid analog ; Antitumor activity ; P388 leukemia ; Cell culture ; Growth inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 4,4′-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13, 15,17-octadecanonaen-1,18-diyl) bis (1-ethylpyridinium) dibromide (Y-18598), a novel carotenoid analog with 1-ethylpyridine rings as terminal groups, was found to be effective against P388 leukemia which was refractory to amphotericin B and retinoic acid used as representatives of polyene-containing drugs. The life span of leukemic mice was increased by 56% over the control following administration of 2.5 mg/kg on days 1–5. Among these polyene-containing compounds, Y-18598 was the most highly cytotoxic to P388 leukemia cells in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390366
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  • 7
    Electronic Resource
    Electronic Resource
    Increased capillary density due to atrophy of ischaemic soleus muscle of the rat (1994)
    Springer
    European journal of applied physiology 69 (1994), S. 387-391 
    Details
    ISSN: 1439-6327
    Keywords: Atrophy ; Capillaries ; Fibre area ; Ischaemia ; Ligation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This investigation was undertaken to determine whether a severe limitation of blood supply by external iliac artery ligation can change the number and density of capillaries in rat soleus muscle. The external iliac artery in one hindlimb was ligated for 2, 7 or 28 days, and the other, sham-operated, hindlimb was used as a control. Muscle blood flow in the ischaemic soleus muscle at 2, 7 and 28 days after external iliac artery ligation was significantly decreased compared with the control. The muscle fibre area and the ratio of the fibre area to body mass in the ischaemic soleus muscle at 28 days after the external iliac artery ligation were significantly reduced in the ischaemic solens muscle, but no change in the number of capillaries per fibre was observed. Capillary density per millimetres squared at 28 days and the ratios of the number of capillaries around type I fibres to the fibre area at 7 and 28 days were significantly increased in the ischaemic soleus muscle (P〈0.05). These results suggested that long-term severe limitation of blood flow in the soleus muscle by ligation of the external iliac artery could have induced the increase in capillary density, as a result of atrophy of muscle fibres rather than capillary growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00865400
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