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  • 1
    Digitale Medien
    Digitale Medien
    METABOLIC STUDIES ON 125I-LABELLED BETA-TRACE PROTEIN, WITH SPECIAL REFERENCE TO SYNTHESIS WITHIN THE CENTRAL NERVOUS SYSTEM (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 21 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract— By means of single radial immunodiffusion on agar, the concentration of beta-trace protein in serum was estimated to about 0.4 mg per 100 ml, i.e. seven times lower than the concentration in CSF. The turnover time in serum was found to be about 1.2 h and the daily amount of beta-trace protein metabolized was approx. 240 mg. The turnover time in CSF was about 3 h after injection of 125I-labelled beta-trace protein into the lumbar spinal space. The data suggest a synthesis of beta-trace protein within the CNS of about 30 mg daily, i.e. one-eighth of the intravascularly metabolized beta-trace protein.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb07570.x
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  • 2
    Digitale Medien
    Digitale Medien
    IMMUNOCHEMICAL AND IMMUNOFLUORESCENCE STUDIES OF BETA-TRACE PROTEIN IN DIFFERENT SPECIES AND ORGANS, WITH SPECIAL REFERENCE TO THE CENTRAL NERVOUS SYSTEM (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 21 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: —The localization of beta-trace protein in different human organs and in the brains of other mammals has been investigated with immunochemical and immunofluorescence methods. With the double immunodiffusion technique, the immunological identity between beta-trace protein in human CSF, brain, femoral nerve, testis, epididymis, spermatic cord, ovary and fallopian tube and in monkey brain could be demonstrated. By means of single radial immunodiffusion on agar, the highest concentrations of beta-trace protein were found in preparations of water-soluble proteins of brain and genital organs, especially in white CNS matter, testis and epididymis. With the indirect immunofluorescence technique, bright fluorescence was found in CNS, especially in white matter, and in the stroma of epididymis. The content of beta-trace protein in femoral nerve was found to be considerably lower than that in the CNS. The results indicate a connexion between beta-trace protein and the CNS, probably in the myelin or glial cells, and also between beta-trace protein and the genital system, possibly to cells involved in steroid metabolism. A specificity for highly developed mammals, i.e. man and monkey, is proposed for beta-trace protein, as no precipitation could be found when brain extracts from calves, rabbits or mice were incubated with anti-serum against human beta-trace protein.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb06007.x
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  • 3
    Digitale Medien
    Digitale Medien
    Symptoms of classic migraine attacks: Modifications brought about by metoprolol (1988)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 8 (1988), S. 0 
    Details
    ISSN: 1468-2982
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: There is little information available concerning whether, and to what extent, migraine-prophylactic agents interfere with the symptoms of migraine attacks. The present study is a placebo-controlled, double-blind study concerning metoprolol in classic migraine. The data refer to the symptoms of single migraine attacks. During metoprolol treatment more attacks were characterized as mild (p = 0.002), and mean global rating (an integrated estimate of headache intensity and of other discomfort) was lower (4.2 versus 5.2, p = 0.003). The mean headache intensity per attack (1.97 versus 2.15) and the mean duration (5.5 versus 6.8 h) were not significantly different. Consumption of analgesics per attack was lower during metoprolol treatment (0.6 versus 1.1; p = 0.02). Attacks with associated symptoms accompanying the headache were fewer during metoprolol treatment (p = 0.014). Total visual and non-visual aura symptoms occurred with similar frequency, but scintillations and paraesthesia were more frequent during metoprolol treatment, whereas speech disturbances were less frequent. In spite of lower consumption of analgesics, the symptoms appeared milder during metoprolol than during placebo. The pattern of changes indicates that metoprolol exerts its action via the sympathetic nervous system; peripheral vasoconstriction is hardly the underlying mechanism of action.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-2982.1988.0804279.x
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  • 4
    facet.materialart.
    Unbekannt
    Visual Memory-Span in the Deaf (1966)
    Urbana, etc. : Periodicals Archive Online (PAO)
    American Journal of Psychology. 79:3 (1966:Sept.) 480 
    Details
    ISSN: 0002-9556
    Thema: Psychologie
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1016-1966-079-03-000015
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  • 5
    Digitale Medien
    Digitale Medien
    The cerebrospinal fluid and plasma concentrations of γ-trace and β2-microglobulin at various ages and in neurological disorders (1980)
    Springer
    Journal of neurology 223 (1980), S. 159-170 
    Details
    ISSN: 1432-1459
    Schlagwort(e): Cerebrospinal fluid proteins (analysis) ; β2-microglobulin ; Bloodbrain barrier ; Cerebrospinal fluid (metabolism) ; Age factors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die Konzentration von γ-Trace und β2-Mikroglobulin wurde in Liquor und Plasma von 64 Personen unterschiedlichen Alters bestimmt, welche keine Zeichen einer organischen Störung des ZNS aufwiesen. Es zeigte sich ein enger Zusammenhang zwischen der Liquorkonzentration von γ-Trace und dem Alter der betreffenden Person, wobei Neugeborene einen 3–4fach höheren Wert als Erwachsene aufwiesen. Eine ähnliche, jedoch weniger ausgeprägte Altersabhängigkeit wurde für die Konzentration von β2-Mikroglobulin im Liquor festgestellt. Die Plasmakonzentration der beiden Proteine variierte ebenfalls je nach Alter der Person, die Schwankungen waren jedoch nicht so deutlich wie im Liquor. Diese Ergebnisse zeigen, daß es dringend erforderlich ist, für die Bestimmung der Proteine in Liquor und Plasma Kontrollwerte aus der betreffenden Altersgruppe zu verwenden. Zusätzlich wurden 13 Kinder und 98 Erwachsene mit neurologischen Erkrankungen untersucht. Signifikant erhöhte Liquorwerte von γ-Trace und β2-Mikroglobulin, eine erhöhte Plasmakonzentration von γ-Trace sowie ein erhöhter Liquor/Plasma-Gradient für β2-Mikroglobulin wurden bei Infektionskrankheiten gefunden. Bei cerebrovasculären Erkrankungen waren die γ-Trace-Konzentration im Plasma und der β2-Mikroglobulin-Wert im Liquor erhöht. Die Mechanismen der Proteinregulierung im Liquor werden diskutiert.
    Notizen: Summary The concentrations of γ-trace and β2-microglobulin in cerebrospinal fluid (CSF) and plasma were determined in 64 individuals of various ages without signs of organic disorder in the central nervous system (CNS). A strong connection was found between the CSF level of γ-trace and the age of the individual, with the CSF level of newborns being 3–4 times that of adults. A similar, but less marked, connection was found for the CSF level of β2-microglobulin and the age of the individual. The plasma levels of the two proteins also varied with the age of the individual, but the variations were not as great as those of the CSF levels. The results strongly emphasize the necessity of using age-matched reference values when CSF and plasma levels of the proteins are to be evaluated in different groups of patients. thirteen children and 98 adults with various neurological disorders were also examined. Significantly increased CSF levels of γ-trace and β2-microglobulin as well as increased plasma concentration of γ-trace and CSF/plasma gradient of β2-microglobulin were found in infectious disorders. Increased γ-trace concentration in plasma and β2-microglobulin concentration in CSF were seen in cerebrovascular disorders. The mechanisms which regulate the turnover of proteins in CSF are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00313180
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