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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food processing and preservation 24 (2000), S. 0 
    ISSN: 1745-4549
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Utilization of ultrafiltered (UF) milk for the manufacture of frozen yogurt was investigated. Three basic frozen yogurt mixes (0, 2, and 4% milk fat) were formulated using ultrafiltered skim milk as a base material and fermented with Lactobacillus acidophilus, Bifidobacterium bifidum, and a mixed yogurt culture of Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus. the cultured mixes were frozen using a continuous freezer and evaluated for product stability. Results suggest that culture organisms grew well during fermentation and produced acids continuously in the UF mixes, which became excessively viscous at a TA of 0.40% or higher. Therefore, all mixes were fermented to 0.30% TA (±4h) and rapidly cooled to 10C or lower to prevent excessive viscosity development. the finished products contained high levels of protein and calcium as well as good flavor and textural quality. In addition, the culture organisms were stable during six weeks of frozen storage.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0843
    Keywords: Key words Gastric cancer ; Chemotherapy ; Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A phase II study was performed to assess the efficacy and toxicity of the combination of 5-fluorouracil (5-FU), leucovorin (LV), etoposide, and cisplatin (FLEP) in patients with advanced gastric carcinoma. A total of 46 consecutive, previously untreated patients with unresectable, measurable gastric carcinoma were treated with 300 mg/m2 LV, 100 mg/m2 etoposide, 500 mg/m2 5-FU, and 30 mg/m2 cisplatin on days 1–3 every 28 days. All courses were given on an outpatient basis. A total of 169 courses of treatment were given. In all, 18 of the 46 patients (39%) had an objective response [95% confidence interval (CI), 25%–54%] and 2 (4%) patients experienced a clinical complete response. The median duration of response was 5 months. The main side effects were hematological and gastrointestinal. Grade 3–4 toxicity was encountered as follows: leukopenia, in 9.5% of the courses; anemia, in 3%; thrombocytopenia, in 3%; nausea/ vomiting, in 4%; and diarrhea, in 5%. Hospitalization due to fever and granulocytopenia was required in 5 patients, 3 of whom died of sepsis. In conclusion, FLEP shows moderate activity in patients with advanced gastric carcinoma, albeit at the cost of a high degree of toxicity. For this reason we do not recommend its use.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0843
    Keywords: Gastric cancer ; Chemotherapy ; Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A phase II study was performed to assess the efficacy and toxicity of the combination of 5-fluorouracil (5-FU), leucovorin (LV), etoposide, and cisplatin (FLEP) in patients with advanced gastric carcinoma. A total of 46 consecutive, previously untreated patients with unresectable, measurable gastric carcinoma were treated with 300 mg/m2 LV, 100 mg/m2 etoposide, 500 mg/m2 5-FU, and 30 mg/m2 cisplatin on days 1–3 every 28 days. All courses were given on an outpatient basis. A total of 169 courses of treatment were given. In all, 18 of the 46 patients (39%) had an objective response [95% confidence interval (CI), 25%–54%] and 2 (4%) patients experienced a clinical complete response. The median duration of response was 5 months. The main side effects were hematological and gastrointestinal. Grade 3–4 toxicity was encountered as follows: leukopenia, in 9.5% of the courses; anemia, in 3%; thrombocytopenia, in 3%; nausea/vomiting, in 4%; and diarrhea, in 5%. Hospitalization due to fever and granulocytopenia was required in 5 patients, 3 of whom died of sepsis. In conclusion, FLEP shows moderate activity in patients with advanced gastric carcinoma, albeit at the cost of a high degree of toxicity. For this reason we do not recommend its use.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    International Journal of Law and Psychiatry 17 (1994), S. 253-263 
    ISSN: 0160-2527
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology , Law
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    International Journal of Law and Psychiatry 5 (1982), S. 413-418 
    ISSN: 0160-2527
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology , Law
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 560 (Nov. 2007), p. 121-126 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This work analyses the changes induced on the microstructure and mechanical propertiesof ultrafine (0.2 and 0.4 μm) hardmetal grade WC-7wt.% Co by HIP after vacuum sintering. A largeHIP pressure (155 MPa) is applied to the ultrafine hardmetal system at different temperatures(1000, 1200 and 1400 °C). The well-known correlation between porosity reduction and fracturestrength improvement is confirmed. Residual porosity left after liquid phase sintering is removedmore effectively at HIP temperatures above the eutectic point of the alloy (1400 °C). In the absenceof grain growth inhibitors, hardness decreases continuously, and WC-Co ultrafine microstructurecoarsens as HIP temperature rises. However, for specimens containing VC and Cr3C2 additions,hardness increases as HIP temperature rises from 1200 to 1400 ºC. It is proposed that thisanomalous trend (confirmed by grain size observations) is related to the activation of coalescencemechanisms during solid state HIPing, which are inhibited by the presence of a liquid phase
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0843
    Keywords: Key words Malignant melanoma ; Chemotherapy ; Cisplatin ; Tamoxifen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A phase II study was performed to assess the efficacy and toxicity of the combination of cisplatin (CDDP) and tamoxifen (TAM) in patients with metastatic malignant melanoma (MM). A total of 31 consecutive previously untreated patients with unresectable measurable MM were given 100 mg/m2 CDDP every 21 days and 60 mg TAM every 12 h daily. All courses were given on an outpatient basis. A total of 119 courses of treatment were given. In all, 5 of the 31 patients (16%) had an objective response (95% confidence interval 5.3 – 34%) and 2 (6%) achieved a clinical complete response. The median duration of response was 7 months. The main side effect was gastrointestinal: 13% of the patients experienced grade 3/4 nausea/vomiting. Hematological or neurological toxicities were mild and rare. In conclusion, the combination CDDP-TAM has limited activity in MM, although its toxicity is tolerable. Our results do not allow us to recommend its use for the treatment of MM.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Supportive care in cancer 4 (1996), S. 61-63 
    ISSN: 1433-7339
    Keywords: Truth disclosure ; Cancer communication ; Psychological stress in doctors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Giving bad news to patients with cancer may generate stress in doctors, who use distancing tactics. The causes of this anxiety come from social conventions and its consequences affect both doctors and their patients. There is no “gold standard” by which stress may be overcome during the interview but we offer some suggestions that may help.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Neurochemical research 7 (1982), S. 317-328 
    ISSN: 1573-6903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Isolated frog rod outer segments (ROS) with a leaky plasma membrane showed a bicarbonate-dependent, ATP-activated45Ca accumulation. This calcium uptake requires magnesium and is specific for ATP; Other nucleotides, ITP, GTP, UTP and the non-hydrolysable analogue of ATP β-γ-methylene ATP did not substitute for ATP.45Ca accumulation was inhibited by mersalyl, ethylmaleimide, ruthenium red, oligomycin and dicyclohexylcarbodiimide and was unaffected by ouabain. Addition of taurine to the incubation medium enhanced45Ca uptake in a concentration-dependent manner; increases of more than 100% being produced by 25 mM taurine. The taurine-induced stimulation of45Ca uptake was also sensitive to the tested inhibitors. The effect of taurine was only exerted on the bicarbonate-dependent, ATP-activated45Ca uptake. Calcium accumulation observed in the absence of ATP or in a tris-buffered medium was unaffected by taurine. Other amino acids, glycine, GABA, β-alanine, glutamic acid and the taurine analogue guanidinoethyl-sulfonate did not stimulate45Ca uptake. These results suggest that taurine is affecting a Mg-ATPase activity responsible for calcium accumulation in frog ROS.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    International journal of theoretical physics 38 (1999), S. 131-142 
    ISSN: 1572-9575
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We discuss the validity of a relation betweenfunctionals in quantum resonance scattering which isoften used in the current literature.
    Type of Medium: Electronic Resource
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