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Digitale Medien

Immunohistochemical study of PCNA (proliferating cell nuclear antigen) in normal and abnormal endometrium (1993)

Ito, Kiyoshi ; Sasano, Hironobu ; Watanabe, Keiko ; [weitere]

238 Main Street, Cambridge, Massachusetts 02142, USA : Blackwell Scientific Publications

International journal of gynecological cancer 3 (1993), S. 0

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Details

ISSN: 1525-1438

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: To investigate the cell kinetics of human endometrial disorders immunolocation of PCNA (proliferating cell nuclear antigen) was performed in 69 specimens of normal, hyperplastic, or malignant endometrial tissue that had been fixed in formalin and embedded in paraffin. Immunoreactivity of PCNA was observed in all specimens examined. In the proliferative phase, PCNA positive cells were present in both the glands and stroma. In the secretory phase PCNA positive cells were seen principally in the stromal cells. A PCNA labeling index was obtained by counting one thousand cells per case. PCNA positivity in the proliferative phase was significantly higher than in the secretory phase (P 〈 0.01), but lower than in moderately differentiated (P 〈 0.01) or poorly differentiated (P 〈 0.05) adenocarcinoma. No significant differences in the PCNA labeling index were observed between hyperplasia and adenocarcinoma. These findings indicate that possible biologic differences between these proliferative endometrial lesions are probably not due to differences in cell proliferative activity, but rather to factors other than proliferation such as their ability to invade.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1525-1438.1993.03020122.x

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Digitale Medien

A case of mosaic trisomy 14 due to an isochromosome, i(14q) (1984)

Ozawa, Nobuyoshi ; Xu, Zhi-Da ; Soh, Kan-ichi ; [weitere]

Springer

Journal of human genetics 29 (1984), S. 69-76

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ISSN: 1435-232X

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary A malformed male infant showed a mosaic trisomy 14 with a karyotype of mos 46,XY/46,XY,−14,+i(14q). The mosaicism was found both in peripheral blood cultures and in lymphoblastoid cells transformed by EB virus infection. His clinical picture was compared with those of 5 previously reported cases of trisomy 14 mosaicism, and the following common phenotypic features were noted: growth retardation, psychomotor delay, narrow or asymmetrical palpebral fissures, broad nose, low-set and dysplastic ears, high-arched palate, micrognathia, short neck, congenital heart disease, and undescended testes.