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  • 1
    Electronic Resource
    Electronic Resource
    Insulin action and insulin binding following pancreas transplantation (1991)
    Springer
    Diabetologia 34 (1991), S. S71 
    Details
    ISSN: 1432-0428
    Keywords: Pancreas transplantation ; Insulin resistance ; Insulin action ; Insulin binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin action and insulin specific binding to erythrocytes were examined in ten recipients of a pancreatic segment and renal graft (Group 1), in nine non-diabetic kidney recipients (Group 2) and in ten age- and weight-matched healthy control subjects (Group 3). All transplant recipients were normoglycaemic without need of insulin, received the same immunosuppression and had good renal graft function at 11–18 months post-transplantation, when the investigation was performed. Using the insulin clamp technique, insulin action was expressed as the metabolic clearance rate of glucose at insulin infusion rates of 1.0 (MCRsubmax) and 10.0 (MCRmax) mU·kg−1·min−1. In comparison with the healthy control subjects, fasting free insulin and C-peptide levels were significantly higher in Groups 1 and 2, but no differences between Groups 1 and 2 were found (p〉0.05). Mean values±SEM of MCRsubmax in Groups 1, 2 and 3 were 6.30±0.55, 6.09 ±0.69 and 10.52±1.10 ml·kg−1·min−1 respectively, and of MCRmax 12.65±0.78, 13.14±0.92 and 19.28±1.42 ml·kg−1·min−1 respectively. Insulin action was significantly decreased in Groups 1 and 2 at the low as well as the high insulin infusion rates but there was no difference between the two groups of recipients (p〉0.05). No differences in binding data (specific binding, number of binding sites per cell) were found. It is concluded that insulin resistance is common to all immunosuppressed organ recipients and is not related to the pancreas graft. The decreased maximal response to insulin and normal insulin binding to erythrocytes tend to suggest a post-receptor defect in insulin action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587624
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of insulin and lipid emulsion on renal haemodynamics and renal sodium handling in IDDM patients (1996)
    Springer
    Diabetologia 39 (1996), S. 1074-1082 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin-dependent diabetes mellitus ; insulin infusion ; lipid emulsion ; glomerular filtration rate ; renal sodium reabsorption.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate the role of insulin and hypertriglyceridaemia in the regulation of renal haemodynamics and sodium handling in insulin-dependent diabetes mellitus (IDDM), 11 IDDM patients without microalbuminuria and 13 weight-, age-, protein intake- and sex-matched healthy control subjects were studied. Clearances of inulin (Cin), para-amino-hippuric acid (CPAH), sodium (CNa), and lithium (CLi) were measured in four 60-min clearance periods (periods I, II, III and IV) during isoinsulinaemia with lipid emulsion infusion (study 1), a hyperinsulinaemic isoglycaemic clamp with Intralipid infusion (study 2), and during time-controlled isoinsulinaemia (study 3). We found that Cin, CPAH and filtration fraction were comparable in IDDM and control subjects, whereas CNa was decreased in diabetic subjects (2.01 ± 1.11 vs 3.03 ± 1.32 ml/min; p 〈 0.05) due to elevations of proximal tubular fractional and absolute reabsorptions of sodium (p 〈 0.05). Insulin infusion did not affect Cin, increased CPAH (p 〈 0.05) and, consequently, lowered the filtration fraction (p 〈 0.01) in both groups. While acute hyperinsulinaemia resulted in increases in distal tubular fractional and absolute reabsorptions of sodium (p 〈 0.01) contributing to a fall in CNa (p 〈 0.01) in control subjects, in diabetic subjects the sodium-retaining effect of insulin was not significant. The lipid emulsion did not alter any of the estimated parameters. We conclude that IDDM without microalbuminuria is associated with a tendency to sodium retention which is not aggravated by insulin when compared to control subjects. Acutely induced hypertriglyceridaemia does not alter renal haemodynamics or renal sodium handling. [Diabetologia (1996) 39: 1074–1082]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400657
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of insulin and lipid emulsion on renal haemodynamics and renal sodium handling in IDDM patients (1996)
    Springer
    Diabetologia 39 (1996), S. 1074-1082 
    Details
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes mellitus ; insulin infusion ; lipid emulsion ; glomerular filtration rate ; renal sodium reabsorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate the role of insulin and hypertriglyceridaemia in the regulation of renal haemodynamics and sodium handling in insulin-dependent diabetes mellitus (IDDM), 11 IDDM patients without microalbuminuria and 13 weight-, age-, protein intake- and sex-matched healthy control subjects were studied. Clearances of inulin (Cin), para-amino-hippuric acid (CPAH), sodium (CNa), and lithium (CLi) were measured in four 60-min clearance periods (periods I, II, III and IV) during isoinsulinaemia with lipid emulsion infusion (study 1), a hyperinsulinaemic isoglycaemic clamp with Intralipid infusion (study 2), and during time-controlled isoinsulinaemia (study 3). We found that Cin, CPAH and filtration fraction were comparable in IDDM and control subjects, whereas CNa was decreased in diabetic subjects (2.01±1.11 vs 3.03±1.32 ml/min; p〈0.05) due to elevations of proximal tubular fractional and absolute reabsorptions of sodium (p〈0.05). Insulin infusion did not affect Cin, increased CPAH (p〈0.05) and, consequently, lowered the filtration fraction (p〈0.01) in both groups. While acute hyperinsulinaemia resulted in increases in distal tubular fractional and absolute reabsorptions of sodium (p〈0.01) contributing to a fall in CNa (p〈0.01) in control subjects, in diabetic subjects the sodium-retaining effect of insulin was not significant. The lipid emulsion did not alter any of the estimated parameters. We conclude that IDDM without microalbuminuria is associated with a tendency to sodium retention which is not aggravated by insulin when compared to control subjects. Acutely induced hypertriglyceridaemia does not alter renal haemodynamics or renal sodium handling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400657
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Metabolic Effects of Omega-3 Fatty Acids in Type 2 (Non-Insulin-Dependent) Diabetic Patients (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 683 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb35716.x
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of acute hyperinsulinemia on fatty acid composition of serum lipids in non-insulin-dependent diabetics and healthy men
    Amsterdam : Elsevier
    Clinica Chimica Acta 203 (1991), S. 329-337 
    Details
    ISSN: 0009-8981
    Keywords: Fatty acid composition ; Glycemic clamp ; Insulin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(91)90305-V
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Insulin binding to erythrocytes and fatty acid composition of erythrocyte membrane phospholipids in healthy men
    Amsterdam : Elsevier
    Clinica Chimica Acta 179 (1989), S. 197-200 
    Details
    ISSN: 0009-8981
    Keywords: Arachidonic acid ; Insulin receptor ; Linoleic acid
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(89)90167-8
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    Paper (German National Licenses)
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