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  • 1
    Electronic Resource
    Electronic Resource
    The development of manifest psoriatic lesions is linked with the appearance of ICAM-1 positivity on keratinocytes (1995)
    Springer
    Archives of dermatological research 287 (1995), S. 165-170 
    Details
    ISSN: 1432-069X
    Keywords: Psoriasis ; Koebner phenomenon ; Immunology ; ICAM-1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The development of psoriatic lesions was studied in 36 psoriatic patients using the Koebner reaction induced by tape stripping. Two biopsies per patient were taken from non-lesional psoriatic skin before, and 6 h, 2 days, 7 days, 14 days and 21 days after tape stripping. Alterations in HLA-DR, ICAM-1, Ki-67 and FXIIIa positivities in both the dermis and the epidermis were estimated using immunohistochemical methods. A double staining for CD4+ and CD8+ T cells was also carried out to show their possible Ki-67 positivity. Results were compared with those from lesional (mature plaque) and non-lesional psoriatic skin, and control skin. Of the 36 patients, 9 were Koebner-positive. The most important finding in Koebner-positive psoriatic skin was the appearance of ICAM-1 positivity on epidermal keratinocytes simultaneously with the clinically observed lesion on day 7. The number of FXIIIa+ dendrocytes in the dermis was quite constant, and increased in mature psoriatic lesions only. The number of active HLA-DR+ immunocompetent cells increased in developing psoriatic lesions, being highest in mature lesions, but no Ki-67 positivity was detected in epidermal or dermal T cells in the psoriatic specimens. Based on these results, it is concluded that T cells divide and are activated extracutaneously in psoriasis, and also that ICAM-1/LFA-1 interactions are important in the recruitment of inflammatory cells and in controlling the effector cell functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01262326
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  • 2
    Electronic Resource
    Electronic Resource
    Morphometry of articular cartilage: A stereological method using light microscopy (1984)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 210 (1984), S. 675-682 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A stereological method is introduced for studying the light microscopic morphometry of articular cartilage. New parameters are presented for defining the three-dimensional structure of the articular cartilage. These include volume density of the lacunae and nuclei, numerical density of cells in 3-dimensional space, total number of cells, total volume of the lacunae in cartilage, volume and diameter of the lacuna and nucleus, the nucleus/lacuna volume ratio, and the mean volume of the matrix per cell. Using the lateral tibial condyle of the knee joint of eight rabbits, we investigated tissue preparation, sampling, morphometry, and the conditions necessary for validity and precision of the estimators. The method proved easy to use, and the estimators were precise.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092100415
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  • 3
    Electronic Resource
    Electronic Resource
    Decrease of proteoglycan granule number but increase of their size in articular cartilage of young rabbits after physical exercise and immobilization by splinting (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 219 (1987), S. 45-52 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The effects of physical exercise (running) and immobilization by splinting on the number and size of proteoglycan (PG) granules and the diameter of collagen fibers of the articular cartilage were studied with the transmission electron microscope with a stereological method. The lateral tibial condyles of 24 young rabbits were examined. The analysis was carried out in the superficial, middle, and deep zones of uncalcified articular cartilage and also in the pericellular, territorial, and interterritorial regions of each zone. PGs were demonstrated in situ by using en bloc staining with the cationic dye ruthenium red, which binds to negative groups of glycosaminoglycans. Results of the control group showed that there was a large pericellular number of PG granules, and the number of granules tended to increase through cartilage depth. The mean diameter of PG granules was highest in the superficial zone and decreased through cartilago depth. The collagen fibers were thicker in the interterritorial than in the territorial region and their diameters increased from superficial toward the deep zone of uncalcified cartilage. Results of the experimental groups showed that the number of ruthenium-red-positive PG granules decreased by 3-46% in all zones and regions after both physical exercise and joint immobilization. On the other hand, the diameter of PG granules increased by 4-42% in all zones and regions in all groups. Collagen fibers in the territorial region of the middle zone were thinner in the exercised and in the splinted knee, while thicker in the contralateral knee to the splinted limb, as compared with the controls. Depending on its degree, mechanical stress or loading of the joint is suggested to have either anabolic or catabolic effects on articular cartilage.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092190109
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    Paper (German National Licenses)
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