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  • 1
    Electronic Resource
    Electronic Resource
    A histochemical study of arylaminopeptidases in hydantoin induced hyperplastic, healthy and inflamed human gingiva (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 8 (1973), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Arylaminopeptidase activity in hydantoin induced hyperplastic, inflamed and healthy human gingiva was studied using various N-L-aminoacyl-2-naphthylamines as substrates. The activity was seen to be located in the basal cell layer of the epithelium in the entire connective tissue, but it was strongest just below the epithelium in all tissues. High enzymic activity was also observed in the inflammatory cells as well as in the capillary walls of hydantoinhyperplastic and inflamed gingiva. Strong enzymic activity was obtained when N-L-alanyl-, N-L-methionyl- and N-L-leacyl-2-naphthylamine were used as substrates. Moderate activity was observed with N-L-arginyl-2-naphthylamine and N-Llysyl-2-naphthylamine in other tissues except in healthy gingiva where the enzymic activity was low or nil. To test the possible involvement of aminopeptidase B in the material the reactions were performed both in the presence and absence of 0.2 M sodium chloride, which specifically activates this enzyme. There was no observable enzymic activity in any slices when N-L-prolyl-2-naphthylamine was used as substrate.The role of different arylaminopeptidases in connection with gingival hyperplasia caused by diphenylhydantoin and the evident absence of enzymes specific to N-L-prolyl-2-naphthylamine are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1973.tb00738.x
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibition of bone collagen synthesis by dental plaque extract (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 20 (1985), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dental plaque extract in low doses inhibited the synthesis of collagen in cultured fetal rat calvaria. Using higher doses of the extract or longer treatment periods the synthesis of noncollagen proteins was also decreased. The denatured extract was as effective as the native one. Although the production of type I collagen in the treated bones was markedly decreased the hydroxylation stage of collagen was not altered. The results suggest that dental plaque extract inhibits the synthesis of collagen by bone cells, which may be one reason for the net loss of collagen of alveolar bone in periodontitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1985.tb00848.x
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  • 3
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of epithelial cells expressing transferrin receptors in normal and diseased human dento-gingival junction (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 23 (1988), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The rate of cell proliferation, which is associated with the density of transferrin receptors on the cell surface, may have an effect on the homeostasis of epithelial cell populations in the dento-gingival junction. In addition to moderate labeling of basal cells, intensive labeling of transferrin receptors was found on suprabasal cells of sulcular epithelium towards the gingival margin of healthy tissues. In contrast, biopsies from diseased tissue exhibited increased labeling towards the base of the pocket. This distribution of labeling suggests that the distinct suprabasal population of cells expressing the transferrin receptors is associated with the process of pocket formation. The density of transferrin receptors decreased towards the lamina propria of gingiva and towards the apical termination of the junctional epithelium. In samples from periodontal pockets, the number of receptors was high eveo in the germinative cell layers. Labeled cells were also demonstrated in crevicular washings. The washing method together with the demonstration of transferrin receptors may provide a new approach for the study of epithelial cell homeostasis in the dento-gingival tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1988.tb01355.x
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  • 4
    Electronic Resource
    Electronic Resource
    Enhanced synthesis of hyaluronic acid by human gingival fibroblasts exposed to human dental bacterial extract (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 18 (1983), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Hyaluronic acid synthesis was studied in human gingival fibroblast cultures exposed to human dental bacterial plaque extract. The cells were stimulated to produce large amounts of hyaluronic acid (HA) into the culture medium. The extract did not have any direct effect on the activity of hyaluronic acid synthetase enzyme complex, indicating that the increased hyaluronic acid synthesis was caused by metabolic alterations in gingival cells. Dental plaque extract also decreased the molecular weight of hyaluronic acid. This was obviously caused by the plaque derived hyaluronidase, because denaturation of plaque proteins by heating prevented this degradation. On the other hand, the stimulatory effect on the HA synthesis by the plaque extract was not destroyed by heating. The increased production of low molecular weight HA by gingival fibroblasts after plaque exposure is suggested to have a role in the pathogenesis of chronic periodontal disease in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1983.tb00332.x
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of pH and ionic strength on the electrophoretic separation of acidic glycosaminoglycans
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 221 (1980), S. 49-57 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0378-4347(00)81006-3
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  • 6
    Electronic Resource
    Electronic Resource
    The Effect of Dental Plaque Grown in the Presence of Xylitol or Sucrose on Bone Resorption in vitro (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 7 (1980), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1980.tb01995.x
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  • 7
    Electronic Resource
    Electronic Resource
    Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 19 (1992), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. A newly developed metronidazole 25% dental gel was compared with subgingival scaling in the treatment of adult periodontitis. 206 patients in 9 centres participated in the study. Probing pocket depth (PPD) and bleeding on probing (BOP) were recorded before treatment and 2, 6, 12, 18, and 24 weeks after the treatment. All patients had at least I tooth in each quadrant with a PPD of 5 mm or more. The treatments consisted of 2 applications of dental gel (days 0 and 7) in 2 randomly selected quadrants (split mouth design) and 2 sessions of subgingival scaling (1 quadrant on day 0, and 1 quadrant on day 7). Instruction in oral hygiene was given 2 weeks after completed treatment. The average PPD and the average frequency of BOP were calculated over all sites with initial PPD of 5 mm or more. PPD and BOP were thus, at each examination, calculated from the same sites. The mean PPD was 5.9 mm before gel application and 5.8 mm before scaling (p= 0.31). BOP was 88% in both treatment groups. 24 weeks after the treatment. PPD and BOP were significantly reduced in both groups and for both parameters (p 〈 0.01). PPD was reduced by 1.3 mm after gel application and 1.5 mm after scaling; BOP was reduced by 32% and 39%, respectively. The difference between the treatments was statistically significant, but considered as clinically unimportant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1992.tb02535.x
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  • 8
    Electronic Resource
    Electronic Resource
    Determination of radioactive proline and hydroxyproline by a simple paper-chromatographic procedure
    Amsterdam : Elsevier
    Journal of Biochemical and Biophysical Methods 6 (1982), S. 47-55 
    Details
    ISSN: 0165-022X
    Keywords: [^3H]- and [^1^4C]proline and -hydroxyrpoline ; bone culture ; collagen synthesis ; paper chromatography
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-022X(82)90025-2
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  • 9
    Electronic Resource
    Electronic Resource
    The interaction of collagenase with hydroxyapatite and related materials and enzymatic properties of the adsorbed enzyme (1978)
    Springer
    Calcified tissue international 25 (1978), S. 127-131 
    Details
    ISSN: 1432-0827
    Keywords: Hydroxyapatite ; Collagenase ; Protein ; Apatite interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The commerical collagenase fromClostridium histolyticum was adsorbed on hydroxyapatite, on bovine femur shaft and on enamel and dentin powders. The substrate specificity of the adsorbed enzyme tested, with chromophore substrate, azocoll and native collagen, differed from that obtained with the soluble enzyme. The adsorption and the substrate specificity was also dependent on the adsorbent used. A pretreatment of hydroxyapatite with chondroitin sulphate, hyaluronate and DNA lowered the adsorption of collagenase. Phosphate ion caused desorption of the enzyme from hydroxyapatite. Sodium fluoride caused partial desorption of the enzyme from hydroxyapatite and enamel and dentin powders. Collagenase adsorbed on root surfaces of teeth liberated hydroxyproline containing material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010761
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