Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of the levels of free and total amitriptyline and metabolites in the plasma and brain of the rat after long-term administration of doses used in receptor studies (1984)
    Springer
    Psychopharmacology 84 (1984), S. 489-495 
    Details
    ISSN: 1432-2072
    Keywords: Amitriptyline ; Hydroxylated metabolites ; Free drug in plasma ; Brain ; Plasma ; Long-term treatment ; Kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was conducted in order to investigate the level of amitriptyline (AT) and its metabolites. Three separate experiments were carried out. In two of these experiments, rats were treated over 7 days with IP doses of AT (10 mg/kg in experiment A and 2×20 mg/kg in experiment C). The rats were sacrificed either 2 (experiment C) or 12h (experiments A and C) after the last dose. In experiment B, rats were sacrificed 2 or 12 h after a single dose of 20 mg/kg AT. The results of these experiments showed the following: in experiment A only AT was measurable in the brain and in the plasma, in contrast to experiments B and C, where NT and the hydroxylated metabolites AT-OH and NT-OH reached significant levels in the plasma and in the brain. The concentrations of AT-OH, NT-OH, and NT (12-h values) that were found in the brain are probably not pharmacologically relevant. The 12-h plasma values of all compounds tested were, even with the highest dose, lower than those expected to be clinically effective in man. Our results suggest that AT, at higher doses, may induce its own metabolism. The free plasma levels of this drug and its metabolites are higher in man than in the rat. The possible implications of these results in the use of antidepressants in the treatment of depression are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431455
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The analysis of free tryptophan in human blood with the ultrafiltrator: A comparison with other methods
    Amsterdam : Elsevier
    Clinica Chimica Acta 76 (1977), S. 223-231 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(77)90100-0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    GC and GC-MS procedures for simultaneous phenotyping with dextromethorphan and mephenytoin
    Amsterdam : Elsevier
    Clinica Chimica Acta 171 (1988), S. 211-222 
    Details
    ISSN: 0009-8981
    Keywords: Dextromethorphan ; Gas chromatography ; Mass spectrometry ; Mephenytoin ; Pharmacogenetics ; Urine
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(88)90146-5
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    β Spectrum of Actinium K (1939)
    [s.l.] : Nature Publishing Group
    Nature 144 (1939), S. 326-326 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE radio-element actinium K recently discovered1 derives from actinium (Z = 89) by emission of an α-particle and is placed in the position 87 of the Mendeléeff table. This element behaves chemically like an alkaline metal, and its period is 21 minutes. Actinium K has been ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/144326a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Interindividual differences in the binding of antidepressives to plasma proteins: the role of the variants of alpha1-acid glycoprotein (1985)
    Springer
    European journal of clinical pharmacology 27 (1985), S. 661-666 
    Details
    ISSN: 1432-1041
    Keywords: amitriptyline ; drug plasma binding ; alpha1-acid glycoprotein ; nortriptyline ; polymorphic forms ; protein variants ; genetic factor ; depression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Alpha1-acid glycoprotein (AAG) is one of the plasma proteins that bind basic drugs, like amitriptyline (AT) and its metabolite nortriptyline (NT). Two types of genetic polymorphism have been described for AAG: polymorphic forms which, on electrophoresis of the native protein, give four patterns with 5, 6, 7 or 8 bands, and the variants which on by electrophoresis of the desialysed protein, give three patterns with 2 bands, FF, FS and SS. In 31 depressive patients, treated daily with 150 mg AT for 3 weeks, free and total plasma AT and NT were determined, as well as the AAG polymorphic forms and variants. There was only a weak negative correlation between the free fractions of AT and NT and total plasma AAG, but free AT and NT were strongly correlated with the S form (but not the F form) of AAG variants. The differences in binding might be the expression of a further genetic factor determining the steady-state plasma levels of tricyclic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547045
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Relationships between brain concentrations of desipramine and paradoxical sleep inhibition in the rat (1983)
    Springer
    Journal of neural transmission 56 (1983), S. 105-116 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Desipramine (DMI), like many antidepressant drugs, inhibits the production of paradoxical sleep (PS). In the present experiment, we have investigated the relationships between brain level of DMI and PS inhibition. Groups of rats had their sleep monitored after 1, 2 or 4 mg/kg of DMI. In other animals, the brain concentration of DMI was assayed at various times after the same treatments. The results indicate that a critical threshold concentration of 300 ng/g DMI in the brain is necessary for Complete PS inhibition. This stage reappears only when the DMI level falls below this value, and its production resumes at a normal rate, provided the DMI level reached initially was not largely in excess of the threshold concentration. The results are discussed with regard to the present knowledge of specific binding of tricyclics in brain and their“ex vivo” action on norepinephrine uptake resulting in enhancement of collateral inhibition of noradrenergic cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01243270
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...