ISSN:
1432-1041
Keywords:
cefoxitin
;
cirrhosis
;
pharmacokinetics
;
ascites
;
ascitic fluid level
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The pharmacokinetics of Cefoxitin was studied in 8 cirrhotic patients with ascites after i.v. administration of a single 30 mg/kg dose. Concentrations of cefoxitin in serum and in ascitic fluid were determined simultaneously by a microbiologic plate diffusion method. The antibiotic followed a two-compartment open kinetic model. In ascitic fluid, Cefoxitin reached its maximum concentration of 32.80±13,78 µg/ml 2 h after administration. The mean elimination constant from ascitic fluid was 0.201±0.008 h−1, significantly lower (p〈0.05) than the slow disposition phase constant (β=0.556±0.17 h−1). At the dose studied and with a dosage interval of 8 h, the level of antibiotic in the ascitic fluid would be maintained at a value greater than the MIC of most cefoxitin-sensitive organisms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00615407
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