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  • 1
    Electronic Resource
    Electronic Resource
    The hamster as an experimental animal for the study of influenza (1976)
    Springer
    Medical microbiology and immunology 162 (1976), S. 227-237 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hamsters previously infected by influenza viruses, have been shown to have a cell-mediated immune response, as measured by the macrophage migration inhibition test. The participation of spleen cells in the protection of recipients against homologous influenza virus infection was also demonstrated using adoptive transfer experiments. However, the protection achieved by spleen cell transfer was marginal and not observed in every animal. The time at which the spleen cells were transferred following infection, and their number, affected the outcome. Evidence suggesting that transferred spleen cells protected recipient hamsters through specific antibody is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02121001
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Transient improvement of polymorphonuclear leukocyte function by splenectomy in β-thalassemia (1987)
    Springer
    Medical microbiology and immunology 176 (1987), S. 209-215 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Host defense mechanisms in transfusion-dependent non-splenectomized patients with β-thalassemia were studied. Polymorphonuclear leukocytes (PMNLs) of non-splenectomized patients responded poorly to zymosan generated chemotactic factors. Chemotactic indices were 22.1 μm ± 2.8 (mean ± S.D.) using zymosan activated serum (ZAS) as the attractant in comparison to 20.4 μm ± 2.6 when fresh untreated serum was used. In contrast, chemotactic indices of normal PMNLs increased from 21.1 μm to 33.6 μm ± 3.1 in response to ZAS. Normal PMNL responses to a mixture of normal ZAS and thalassemic serum were inhibited; the mean chemotactic index was 18.1 μm ± 5.1 with use of ZAS alone. Splenectomy temporarily reverses these alterations. Adherence to nylon wool of PMNLs suspended in fresh thalassemic serum prior to splenectomy was 3.1% ± 1.1 (mean ± S.D.); 20 days after splenectomy adherence increased to 14.0% ± 2.8 (P = 0.0001) and remained at this level for 90 days. At 120 and 150 days after splenectomy adherence decreased to 1.5% ± 0.8 and 1.0% ± 0.85 respectively. Splenectomy also transiently abrogated the failure of zymosan to generate chemotactic factors in thalassemic serum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196688
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Antiviral, immunosuppressive and antitumour effects of Ribavirin (1976)
    [s.l.] : Nature Publishing Group
    Nature 259 (1976), S. 496-497 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 Response of ferrets to infection with influenza virus A/Port Chalmers/73 Control Response to infection* ferrets Ferrets treated with Ribavirin (lOOmgkg^d-1) Rise in temperaturef (C) 39.3-40.9 39.6-39.6 Virus titre in nasal wash at 48 h post-infection (EID50 ml"1) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/259496a0
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    Paper (German National Licenses)
    Fulltext
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