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  • 1
    Electronic Resource
    Electronic Resource
    Local comparison of the genomes of Mycobacterium tuberculosis and Mycobacterium leprae using the polymerase chain reaction (1995)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 132 (1995), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract To facilitate comparison of the genome maps of Mycobacterium tuberculosis and M. leprae, sequence data from the M. leprae sequencing project were used to design primers suitable for the amplification of short segments from conserved genes by the polymerase chain reaction. In most cases, both organisms yielded products of identical size that were then used as probes for a comparative genomic walk. The hybridization data often, but not always, revealed a similar organization of various regions of both genomes. This approach should be useful for systematic comparisons of (myco)bacterial genomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1995.tb07844.x
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  • 2
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    Unknown
    Der Philosemitismus im geistesgeschichtlichen Feld (1958)
    Köln : Periodicals Archive Online (PAO)
    Zeitschrift für Religions- und Geistesgeschichte. 10 (1958) 220 
    Details
    ISSN: 0044-3441
    Topics: History , Philosophy , Theology and Religious Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:6475-1958-010-00-000014
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  • 3
    Electronic Resource
    Electronic Resource
    Leukocyte adhesion molecules in rejected corneal allografts (1994)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 232 (1994), S. 87-95 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Leukocyte adhesion molecules are believed to play a key role in the selective recruitment of different leukocyte populations to inflammatory sites. In this study, we investigated the presence and distribution of intercellular ad hesion molecule-1 (ICAM-1), E-selectin (endothelial leukocyte adhesion molecule-1) and vascular cell adhesion molecule-1 (VCAM1) in 12 rejected corneal allografts and compared the presence of these adhesion molecules with the composition of the associated inflammatory infiltrates. ICAM-1 was focally expressed on corneal epithelial cells and its expression was increased on keratocytes, corneal and vascular endothelial cells particulary at the site of dense infiltration with mononuclear leukocytes. E-selectin was present on endothelial cells of vessels in the stroma of rejected corneal allografts which were characterized by dense infiltration with T cells and macrophages. VCAM-1 was predominantly expressed on inflammatory cells of the macrophage/monocyte lineage, but only sporadically on vascular endothelial cells in thet stroma of vascularized rejected corneal allografts. Our results suggest that ICAM-1, E-selectin and VCAM-1 may all be involved in the pathogenesis of corneal allograft rejection, particulary in the generation of the inflammatory infiltrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171669
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  • 4
    Electronic Resource
    Electronic Resource
    Toxicity and clearance of intravitreal cefotetan (1990)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 228 (1990), S. 475-480 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Direct, intravitreal injection of antibiotics plays an important role in the management of bacterial endophthalmitis. In the present study we investigated the toxicity and clearance of intravitreally injected cefotetan in a rabbit model. No toxic ocular side effects could be detected by electroretinography (ERG) or light and electron microscopy up to and including a single intravitreal dose of 1000 μg. Intravitreal injection of 2000 μg cefotetan resulted in mild degeneration of photoreceptor outer segments and, sporadically, in cataract formation. After intravitreal injection of 4000 μg, moderate toxic degeneration of photoreceptors occurred, with displacement and mitochondrial swelling of inner segments. In addition, lysosomal lamellar inclusion bodies could be detected in pigment epithelial cells. After a single intravitreal injection of 1000 μg cefotetan, concentrations greater than the minimum necessary for the inhibition of most commonly occurring intraocular pathogens (exceptPseudomonas aeruginosa andStaphylococcus epidermidis) were maintained in the vitreous humor for 〉 48 h. Cefotetan may be a potentially important drug for intravitreal injection, especially in cases of gram-negative and suspected anaerobic endophthalmitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00927265
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  • 5
    Electronic Resource
    Electronic Resource
    Clinicopathological findings 11 months after implantation of a functioning aqueous-drainage silicone implant (1990)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 228 (1990), S. 481-486 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An aqueous-drainage silicone device was implanted in a 57-year-old diabetic patient with neovascular glaucoma after failure of conventional therapy. Postoperative intraocular pressure (IOP) was well controlled, ranging between 10 and 20 mm Hg without the use of supplemental agents. Despite the normal IOP, the eye became painful and amaurotic 11 months after implantation due to progression of the retinopathy accompanied by the development of severe tractional retinal detachment. Enucleation was performed and the eye underwent histopathological examination. The filtering bleb around the silicone plate of the implant on the equatorial sclera was lined with a thick layer of collagenous connective tissue. Numerous microcystic spaces could be seen in the bleb wall by light microscopy. Electron microscopy confirmed this finding; in addition, only a meshwork of collagen fibre-like bundles was visible at some areas of the innermost bleb wall. Control of IOP in spite of bleb fibrosis in this particular case may have been due to a loss of matrix components and to the formation of microcystic spaces in the bleb wall, which seem likely to be channels for the passage of aqueous humor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00927266
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  • 6
    Electronic Resource
    Electronic Resource
    The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol (1997)
    [s.l.] : Nature Publishing Group
    Nature medicine 3 (1997), S. 567-570 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Ethambutol (EMB), a frontline antituberculous drug, targets the mycobacterial cell wall, a unique structure among prokaryotes which consists of an outer layer of mycolic acids covalently bound to peptidoglycan via the arabinogalactan. EMB inhibits the polymerization of cell wall arabinan, and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0597-567
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  • 7
    Electronic Resource
    Electronic Resource
    Investigation of visual field defects in strabismic and anisometropic amblyopes with the Octopus Program G1 (1989)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 227 (1989), S. 448-454 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using the Octopus G1 program, we investigated the visual fields of amblyopic and healthy contralateral eyes in 21 patients with strabismic amblyopia and 14 patients with anisometropic amblyopia. All subjects had a visual acuity of 0.7-0.06. A central scotoma was detected in 85.7% of the patients with strabismic amblyopia and in 79% of those with anisometropic amblyopia. The mean maximal depth of central scotomas in subjects with strabismic amblyopia was 6.81 ± 4.74 dB (mean ± SD); in those with anisometropic amblyopia, it was 6.64 ± 4.34 dB. This difference was statistically not significant. However, in patients with anisometropic amblyopia, the visual field indices MD (mean defect) and CLV (corrected loss variation) were significantly higher than in those with strabismic amblyopia (P 〈 0.05 vsP 〈 0.05); this was predominantly due to additional flat defects that occurred paracentrally and peripherally in subjects with anisometropic amblyopia. In both groups of patients, we found a significant negative correlation between visual acuity, on the one hand, and the maximal depth of the scotomas and the visual field indices (MD and CLV), on the other.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02172897
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  • 8
    Electronic Resource
    Electronic Resource
    Über Germacron und seine pyrolytische Umwandlung (1959)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 625 (1959), S. 206-229 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Pyrolyse des Germacrons führt zu Pyrogermacron, einem monocyclischen Sesquiterpenketon der Element-Reihe. Auf spektroskopischem und chemischem Wege wurde das Pyrogermacron als 1-Methyl-1-vinyl-2-isopropenyl-4-isopro-pyliden-cyclohexanon-(5) (III) erkannt. Der Mechanismus seiner thermischen Bildung wird diskutiert.  -  Germacron stellt ein tricyclisches Keton der Maalian-Reihe dar. In Verbindung mit dem UV- und IR-Spektrum ließ sich für Germacron die Konstitution XXIX ableiten.  -  Es wurde gefunden, daß Hydroxylgruppen in unmittelbarer Nachbarschaft zum Cyclopropanring durch MnO2 zu Carbonylverbindungen dehydriert werden.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19596250127
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  • 9
    Electronic Resource
    Electronic Resource
    Zur Kenntnis homologer Alkohole der Terpen- und Sesquiterpenreihe X. Synthese Des (+)-3-Hydroxymethyl-Δ4-Carens (1958)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 613 (1958), S. 43-55 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird die Synthese des (+)-3-Hydroxymethyl-Δ4-carens (II) durch säurekatalysierte Addition von (+)-Δ3-Caren (I) an Formaldehyd beschrieben. Die katalytische Hydrierung von II führt zum (-)-3-Hydroxymethylcaran (III), das als Ausgangsmaterial für Synthesen in der Caran-Reihe verwendet wird. Es werden die IR-Spektren der neuen Verbindungen angegeben und die Zuordnungsmöglichkeiten von Absorptionsbanden zum vollständig substituierten Cyclopropanring diskutiert.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19586130105
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  • 10
    Electronic Resource
    Electronic Resource
    Mycobacterial genome structure (minireview) (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 573-576 
    Details
    ISSN: 0173-0835
    Keywords: Mycobacteria ; Genome organization ; Optical mapping ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Genome maps have been constructed for the mycobacterial pathogens Mycobacterium leprae and Mycobacterium tuberculosis, as well as for the attenuated vaccine strain Mycobacterium bovis BCG Pasteur. While the chromosomes of M. tuberculosis and M. bovis BCG Pasteur show extensive conservation at the grosslevel, comparison with M. leprae revealed a high degree of diversification, with a mosaic-like pattern apparent. The ordered libraries of M. tuberculosis and M. leprae produced during the course of these studies played a central role in the genome sequencing projects of these two bacilli, showing the utility of this approach for systematic sequencing of bacterial genomes.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150190418
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