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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of the antianginal efficacy of four calcium antagonists and propranolol in stable angina pectoris (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 325-331 
    Details
    ISSN: 1432-1041
    Keywords: angina pectoris ; propranolol ; exercise test ; beta-blockers ; calcium antagonists ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The antianginal effects of propranolol 160 mg/day, diltiazem 240 mg/day, nicardipine 80 mg/day, nifedipine 40 to 80 mg/day and verapamil 320 mg/day were compared in 12 patients with chronic stable angina pectoris using a symptom-limited exercise test. Compared to placebo propranolol and calcium antagonists similarly reduced (p〈0.001) the frequency of antianginal attacks and nitroglycerin consumption, and increased exercise tolerance and time to ≥1 mm S-T segment depression. After propranolol the pressure-rate product at submaximal and maximal exercise was significantly decreased. The calcium antagonists produced a significant reduction in the submaximal pressure-rate product, but no significant change in the peak pressure-rate product. Maximum ST depression was significantly lower after propranolol and was unchanged after the calcium antagonists. None of the drugs caused significant adverse effects. The results indicate that in patients with stable effort angina pectoris, diltiazem, nicardipine, nifedipine and verapamil were as effective as propranolol in improving exercise tolerance and time to ischaemia, and they did not alter the peak pressurerate product. Different antianginal mechanisms may be operative for the various calcium antagonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558494
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  • 2
    Electronic Resource
    Electronic Resource
    Antimicrobial effect of six endodontic sealers: an in vitro evaluation (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Dental traumatology 15 (1999), S. 0 
    Details
    ISSN: 1600-0595
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The aim of this study was to determine the in vitro antimicrobial effect of six endodontic sealers after 2, 20 and 40 days.The sealers studied were Apexit, Endion, AH26, AH-Plus, Procosol and Ketac Endo. The microorganisms used were Candida albicans, Stnphylococcus aureus, Streptococcus mutans and Actinomyces israelii. Petri dishes were filled with sterile agar and 0.1-ml wells were prepared and filled with the sealers. The agar plates were stored for 24 h at 37°C. The samples were then removed, immersed in 4.5 ml of culture medium and divided into three groups. The samples in group 1 were stored for 2 days at 37°C whereas the samples of groups 2 and 3 were stored at 4°C for 20 and 40 days respectively. The samples were then removed and discarded, and 0.1 ml of the culture medium was seeded on the agar plates in order to perform colony forming unit counts. Apexit, Endion and AH-Plus produced slight inhibition on Streptococcus mutans at 20 days and on Actinomyces israelii at every time interval. No effect was found on Candida albicans and Staphylococcus aureus. Ketac Endo only produced an antimicrobial effect on Actinomyces israelii at 2 and 40 days. AH26 and Procosol showed antimicrobial effect at 40 days on Candida albicans, at 20 and 40 days on Streptococcus mutans and Staphylococcus aureus, and an effective inhibition on Actinomyces israelii at every time interval. Statistical analysis revealed both sealers and microorganisms to be significant factors affecting results in groups 2 and 3. In conclusion, the sealers evaluated in this study showed different inhibitory effects depending on time span. Overall, sealers containing eugenol and formaldehyde proved to be most effective against the microorganisms at the time intervals studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-9657.1999.tb00748.x
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  • 3
    Electronic Resource
    Electronic Resource
    Models to assess nitrogen losses in pediatric patients on chronic peritoneal dialysis (2000)
    Springer
    Pediatric nephrology 15 (2000), S. 25-30 
    Details
    ISSN: 1432-198X
    Keywords: Key words Measured nitrogen losses ; Chronic peritoneal dialysis ; Models predicting nitrogen losses Urinary nitrogen losses ; Dialysate nitrogen losses ; Fecal nitrogen losses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  To develop models to estimate nitrogen (N) losses of children on chronic peritoneal dialysis (CPD) from easily measurable indexes and laboratory tests, we measured the N content and all nitrogenous compounds in dialysate (D), urine (U), and feces over 3 days in 19 pediatric patients on CPD. Total measured N losses (TNm) were 5.56±2.26 g/day (69.9±11.1% in dialysate, 16.3±10.6% in urine, and 13.6±4.6% in feces). Correlation coefficients between measured dialysate and urinary N losses and the single nitrogenous compounds indicated values of over 0.9 only for urea in dialysate and urine; fecal N losses correlated well with body surface area (BSA). Taking into account these correlations, we developed a univariate additive model and three multivariate models to predict total estimated N losses (TNe). The best prediction of TNm was obtained with model 3, which considered not only urea output in dialysate and urine but also dialysate protein loss and BSA: TNe (g/day)=0.03+1.138 UN urea+0.99 DN urea+1.18 BSA+0.965 DN protein. A confirmatory analysis performed on a second group of 23 pediatric patients on CPD, using all four models, showed a higher percentage of studies with a relative difference between TNm and TNe less than 10% for model 3 than for the other models. Thus, N losses of pediatric patients on CPD can be estimated from measured urea and protein losses in dialysate and urea loss in urine, together with BSA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00013447
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  • 4
    Electronic Resource
    Electronic Resource
    Short-term anabolic effects of recombinant human growth hormone in young patients with a renal transplant (1998)
    Springer
    Transplant international 11 (1998), S. S69 
    Details
    ISSN: 1432-2277
    Keywords: Key words Recombinant human growth hormone ; Renal transplantation ; Children ; Nitrogen balance ; Body composition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Renal-transplanted children may present stunted growth, negative nitrogen balance (Nb), and alterations in body composition. Recombinant human growth hormone (rhGH) is a potent anabolic agent which improves nutritional status and Nb. In renal-transplanted children, rhGH increases growth velocity but its effect on nutritional status has not been reported. We evaluated the effect of 6 months of rhGH treatment on Nb, urea nitrogen appearance (UNA), anthropometric indexes, and growth velocity in 14 pediatric patients with a renal transplant. Nb improved significantly (P = 0.02) and was accompanied by a decrease of UNA. A significant improvement was observed also in mid-arm muscle circumference (P = 0.002), arm muscle are (P = 0.001), and arm fat are (P = 0.017). Growth velocity increased in prepubertal patients (P = 0.003). Creatinine clearance and the number of rejection episodes were not affected by rhGH treatment. In conclusion, short-term administration of rhGH improves Nb and UNA as well as the main indexes of body composition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050429
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    Paper (German National Licenses)
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