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  • 1
    Electronic Resource
    Electronic Resource
    Peptidergic afferents might contribute to the regulation of skin blood flow (1988)
    Springer
    Inflammation research 23 (1988), S. 14-15 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967172
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  • 2
    Electronic Resource
    Electronic Resource
    Neurogenic modulation and vasoactive peptides in microvascular biology (2004)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc
    Experimental dermatology 13 (2004), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Acute neurogenic inflammation is observed after topical application of the TrpV1 agonist capsaicin to the mouse ear. Inflammatory oedema is not detectable in the substance P NK1 receptor knockout mouse, indicating the importance of this receptor in mediating neurogenic oedema formation. However, neurogenic vasodilatation remains not only in the NK1 receptor knockout mouse but also in the CGRP knockout mouse after sensory nerve stimulation. Interestingly, it is abolished when both the CGRP and substance P dilator pathways are blocked. This has led us to suggest that there is a facilitatory interaction between endogenously released CGRP and substance P, such that when both are present there is redundancy in terms of dilator mechanisms. This could be relevant to the apparent maintenance of peripheral vasodilator tone, when either NK1 or CGRP receptor antagonists are given systemically for evaluation as novel therapeutic agents. The relative activity of CGRP and the structurally related non-neuropeptide adrenomedullin have been compared. Adrenomedullin is less potent as a vasodilator, but functionally relevant concentrations can be induced in inflamed skin. Both peptides, as a consequence of their vasodilator activity, influence inflammatory processes (e.g. oedema and cell accumulation) acting through the CGRP receptor. Thus, adrenomedullin can act as a non-neuronally derived CGRP agonist in skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6705.2004.0212ab.x
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  • 3
    Electronic Resource
    Electronic Resource
    Capsaicin-sensitive cutaneous sense organs: Nerve terminals with multiple funcions
    Amsterdam : Elsevier
    Regulatory Peptides 22 (1988), S. 180 
    Details
    ISSN: 0167-0115
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(88)90400-4
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  • 4
    Electronic Resource
    Electronic Resource
    Über Dihydro-3-thioxo-3H-1,2-dithiolo[4,3-d]pyrimidin-5(4H)-one und Dihydro-3H-1,2-dithiolo[4,3-d]pyrimidin-3,5(4H)-dithione Über Heterocyclen, 34. Mitt. (1973)
    Springer
    Monatshefte für Chemie 104 (1973), S. 585-597 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Dihydro-3-thioxo-3H-1,2-dithiolo[4,3-d]pyrimidin-5(4H)-one (2) geben bei Methylierung 4-Methylderivate (2) bzw. Tetrahydro-3-methylthio-5-oxodithiolopyrimidiniumsalze (6); aus den Dithionen (3) entstehen 5-Methylthio-bzw.5-Methylthio-4-methylderivate (4) bzw. Tetrahydro-3-methylthio-5-thioxodithiolopyrimidiniumsalze (6). Peressigsäure führt2 in das Tetrahydrodithiolopyrimidiniumhydrogensulfat (10) über.2 bzw.3 geben mit Phenylhydrazin 3-Phenylhydrazone; Tetrahydro-3-methylthiodithiolopyrimidiniumjodide (6) reagieren mit Aminen bei Anwesenheit vonHMPT zu den 3-Iminoverbindungen.10 gibt mit Methylketonen und Wasserstoffakzeptoren 3-Acylmethylendihydrodithiolopyrimidin-5(4H)-one.
    Notes: Abstract Dihydro-3-thioxo-3H-1.2-dithiolo[4.3-d]pyrimidine-5(4H)-ones (2) give on methylation 4-methylderivatives (2) and tetrahydro-3-methylthio-5-oxodithiolopyrimidinium salts (6) resp.; from dithiones (3) arise 5-methylthio-resp. 5-methylthio-4-methylderivatives (4) resp. tetrahydro-3-methylthio-5-thioxo-dithiolopyrimidinium salts (6). Peracetic acid converts2 to tetrahydrodithiolopyrimidinium hydrogensulphate10. 2 and3, resp. give with phenylhydrazine 3-phenylhydrazones. Tetrahydro-3-methylthiodithiolopyrimidiniumiodides (6) react with amines in presence ofHMPT to 3-iminocompounds.10 gives with methyl ketones and hydrogen acceptors 3-acylmethylendihydro-dithiolopyrimidine-5(4H)-ones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00903126
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  • 5
    Electronic Resource
    Electronic Resource
    Predictive value of neurological abnormalities in HIV 1 patients in the early stages of the infection (1993)
    Springer
    Neurological sciences 14 (1993), S. 171-177 
    Details
    ISSN: 1590-3478
    Keywords: Predictivity ; neurological signs ; multimodal evoked potentials ; HIV1 infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Abbiamo eseguito uno studio longitudinale di follow-up neurologico clinico ed elettrofisiologico su 31 pazienti ambulatoriali sieropositivi per anticorpi anti-HIV1, in stadio di infezione asintomatica o di LAS (CDC II–III). I risultati dell'esame clinico e della registrazione dei potenziali evocati multimodali hanno mostrato una elevata percentuale di alterazioni (rispettivamente nel 42% e nel 39% dei soggetti); in un numero di casi statisticamente significativo tali anomalie si sono rivelate predittive di un successivo peggioramento della situazione immunologica, mettendo così in evidenza la stretta correlazione tra stato neurologico ed immunologico nel corso dell'infezione da HIV1.
    Notes: Abstract A longitudinal clinical neurological and electrophysiological follow-up study was carried out on 31 HIV1 seropositive outpatients in the asymptomatic or LAS stages of the infection (CDC II–III). The results of clinical examination and multimodal evoked potentials (EP) recording showed a high percentage of abnormalities (42% and 39% of cases respectively); in a statistically significant number of subjects these abnormalities were predictive of subsequent immunological deterioration, thus demonstrating the close relationship between neurological and immunological functions in HIV1 infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02335752
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  • 6
    Electronic Resource
    Electronic Resource
    Inhaled Nitric Oxide Therapy in a Critically Ill Neonate with Ebstein's Anomaly (1998)
    Springer
    Pediatric cardiology 19 (1998), S. 477-479 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Nitric oxide — Ebstein's anomaly — Inhalation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The successful use of nitric oxide (NO) inhalation in a critically ill neonate with Ebstein's anomaly of the tricuspid valve is reported for the first time. This use of inhaled NO therapy suggests a therapeutic intervention that directly addresses the pathophysiologic process of severe neonatal Ebstein's anomaly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900362
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  • 7
    Electronic Resource
    Electronic Resource
    Psychische Morbidität der südländischen und osteuropäischen Emigranten in der Schweiz (1968)
    Springer
    Social psychiatry and psychiatric epidemiology 3 (1968), S. 143-148 
    Details
    ISSN: 1433-9285
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Dans cette étude, l'auteur essaie d'analyser quelques syndromes psychiques souvent observés chez les emigrants méditerranéens et européens de l'est, tels que des ouvriers italiens et des réfugiés, hongois vivant en Suisse. Il avance l'hypothèse que la diversité des maladies migratoires est en rapport avec la diversité de l'origine, des motifs migratoires et du rôle social des malades joué dans le pays d'acceuil. La différence principale entre les deux groupes d'émigrants réside dans une différence de structure du Moi de leurs représentants respectifs. L'auteur discute de façon approfondie deux syndromes importants, á savoir, la «dépression hypochondnaque de déracinement» (chez les Italiens) et le «délire de concernement en milieu culturel différent» (chez les Hongrois).
    Abstract: Zusammenfassung In diesem Artikel wurde ein Versuch unternommen, einige charakteristische psychische Zustandsbilder südländischer und osteuropäischer Emigranten am Beispiel von in der Schweiz lebenden italienischen Gastarbeitern und ungarischen Flüchtlingen zu demonstrieren. Dabei wurde die These gestellt, daß die Verschiedenartigkeit der sogenannten migrationsspezifischen Syndrome auf der Verschiedenheit der Herkunft, der Wanderungsmotive und der Sozialrolle im Aufnahmeland beruht. Der Hauptunterschied liegt in der Ichstruktur der Angehörigen der zwei Wandergruppen. Auf zwei häufig beobachtete Zustandsbilder, namentlich auf die „hypochondrische Entwurzelungsdepression“ (bei den Südländern) und den „Beziehungswahn in kulturfremdem Milieu“ (bei den Osteuropäern) sind wir. näher eingegangen.
    Notes: Summary In this paper, the author describes some characteristic psychiatric syndromes in immigrants from southern and eastern Europe, and found in Italian workers and Hungarian refugees living in Switzerland. He puts forward the hypothesis that the variety of psychiatric conditions seen in immigrants is related to the diverse origins, the various motives for migration and the different social roles adopted in the new homeland. The chief difference between the two groups of immigrants lies in a difference in ego-structure. Two frequently observed clinical syndromes, “hypochondriacal depression of emigration” (in southerners) and “delusions of reference in an unfamiliar cultural environment” (in east Europeans), are discussed in more detail.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577945
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  • 8
    Electronic Resource
    Electronic Resource
    Untersuchungen über Chinone, 9. Mitt. Über Acetylderivate vonp-Indazolchinonen (1994)
    Springer
    Monatshefte für Chemie 125 (1994), S. 945-954 
    Details
    ISSN: 1434-4475
    Keywords: p-Indazolquinones ; Hydroquinones ; Acetyl derivatives ; Spectroscopic studies ; Structure elucidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Acetylation of the indazolquinones1a (6-anilino-),b (6-p-toluidino-),c (6-N-methylanilino-),g (6- or 5-methylthio-), andk (benz[f]-) by heating with acetic anhydride yields the 2-acetylindazolquinones4a, b, c, g, andk. Reductive acetylation of the quinones1c, g, h/h 1(6/5-methyl),k and — for structure elucidation — their 1-N- (2c) and 2-N- (3c, 3e)-methyl derivatives with acetic anhydride, zink powder, and sodium acetate gives the 1-acetyl-(7c, g, h/h 1,k), resp. 1-methyl- (8c), and 2-methyl- (9c, e) diacetoxyindazoles. In case of1k, two diacetyl derivatives were isolated in addition to the already known triacetyl derivative7k, regardless of the conditions chosen. Acetylation of the intermediate product of the reaction from phenylthio-benzoquinone with diazomethane also yields a triacetyl-hydroquinone (7f). UV/Vis, IR, and1H NMR spectroscopy were used for structure determination. Comparison of the UV/Vis spectra of the acetyl derivatives4 with those of1, 2, 3, and of compounds7 with those of analog substituted indazols shows that the acetyl group is located in position 2 with compounds4 and in position 1 with compounds7. By means of1H NMR spectra the position of the acetyl group can be determined by the effect of the carbonyl group on the proton in position3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00812709
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of prostaglandin E2 on the permeability of the iris vessels to horseradish peroxidase in the rabbit (1978)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 207 (1978), S. 221-228 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Prostaglandin E2 (0.5 μg in 10 μl 10% ethanol) was introduced into the anterior chambers of rabbit eyes. Using the horseradish peroxidase method, it was shown under the electron microscope that the endothelial barrier of the iris vessels broke down. The peroxidase penetrated as far as the basis of the posterior epithelial cells, however, without entering their lateral intercellular spaces. The question of whether the effect of prostaglandins on the barrier was a direct effect or at least a partially indirect one, i.e., a haemodynamic action, is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411056
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  • 10
    Electronic Resource
    Electronic Resource
    Inflammatory and antiinflammatory effects of antidromic stimulation of dorsal roots in the rat (1988)
    Springer
    Inflammation research 25 (1988), S. 240-242 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Unilateral antidromic stimulation of the rat's lumbar dorsal roots evoked plasma extravasation in the skin of the corresponding hindpaw. Identical antidromic stimulation of the contralateral dorsal roots 4–5 minutes prior to the stimulation inhibited this response by 49%. No inhibition occurred when time interval between the stimulations was 60 minutes. It is concluded that not only inflammatory, but antiinflammatory mediators are released in response to activation of the peripheral endings of primary afferent neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965023
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