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  • 1
    Electronic Resource
    Electronic Resource
    Plasma levels and myocardial content of verapamil, norverapamil and two N-dealkyl-metabolites in man (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 653-657 
    Details
    ISSN: 1432-1041
    Keywords: verapamil ; plasma levels ; myocardial uptake ; verapamil metabolites ; patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma levels and myocardial content of verapamil and its metabolites norverapamil, N-dealkylverapamil and N-dealkylnorverapamil were determined in 15 patients with valvular [3] or ischaemic [12] heart disease. The mean myocardial plasma concentration ratio (M/P) was 7.05 for verapamil, 11.45 for norverapamil, 8.93 for N-dealkylverapamil, and 11.33 for N-dealkylnorverapamil, with great interpatient variability. The highest M/P ratios of verapamil were generally found in patients with the lowest plasma levels, suggesting that saturable tissue uptake may occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607910
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Column liquid chromatographic determination of prajmalium in plasma and urine by direct sample injection
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 415 (1987), S. 183-187 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0378-4347(00)83208-9
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Evaluation of the regional responsivity to ryanodine of human myocardium from patients with idiopathic dilated cardiomyopathy and secondary cardiomyopathies (1996)
    Springer
    Basic research in cardiology 91 (1996), S. 361-366 
    Details
    ISSN: 1435-1803
    Keywords: Human ; myocardium ; cardiomyopathy ; ryanodine ; contractility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the study was to compare the contractile response to ryanodine of human heart preparations taken from right and left ventricles of patients affected by idiopathic (IDCM) and secondary (SCM) endstage dilated cardiomyopathies. Right and left ventricle myocardial strips were obtained from hearts of patients undergoing orthotopic heart transplantation and suspended in an oxygenated bath (T=35°C; stimulation frequency=0.5 Hz). After an equilibration period, a cumulative dose-response curve for contractility (peak tension) was obtained with ryanodine (0.5, 1, 2, 4, 8, 16, 32, 64 μM). Basal contractility was not significantly different between right and left ventricles or between IDCM and SCM preparations. Ryanodine reduced peak myocardial tension but failed to completely suppress it, even at concentrations which achieved maximum effect. Ryanodine effect still persisted after a 45′–60′ washout. The concentration-effect curves from IDCM right ventricle, IDCM left ventricle, SCM right ventricle and SCM left ventricle were compared: IDCM left ventricle was less sensitive to ryanodine than IDCM right ventricle and SCM left ventricle, while no difference was detectabe between SCM left ventricle and SCM right ventricle. Thus, the overall sensitivity ranking was: IDCM left ventricle 〈 IDCM right ventricle SCM right ventricle=SCM left ventricle. IDCM left ventricle showed, in addition, a biphasic response with a shift from negative to positive inotropic effect at concentrations higher than ∼ 10 μM. These findings indicate that the cardiodepressant effect of ryanodine, a drug which interferes with intracellular Ca release from the sarcoplasmic reticulum, differs quantitatively and qualitatively in IDCM left ventricle from both IDCM right ventricle and SCM left ventricle. This suggests that some specific alteration in the intracellular Ca signalling in IDCM exists and, from a methodological point of view, stresses the need for a “bi-ventricular” approach to studying biochemical and functional abnormalities of advanced congestive heart failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00788715
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of dobutamine on left ventricular relaxation and filling phase in patients with ischemic heart disease and preserved systolic function (1993)
    Springer
    Cardiovascular drugs and therapy 7 (1993), S. 325-331 
    Details
    ISSN: 1573-7241
    Keywords: doubtamine ; contractility ; diastolic phase ; coronary artery disease ; relaxation phase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The beneficial effects of dobutamine on left ventricular systolic and diastolic phases have been described in patients with congestive heart failure. Its influence on left ventricular diastolic phase in patients with preserved systolic function, absence of dys- or akinetic areas, and left ventricular dilatation has not yet been adequately investigated. Thus a simultaneous echo-Doppler and hemodynamic study was performed in 15 patients with ischemic heart disease and preserved systolic function in order to assess the effect of dobutamine on left ventricular relaxation and filling phase. The infusion of dobutamine at a rate of 10 µg/kg/min induced a marked inotropic action, as shown by the significant increase in positive dP/dt (from 1392±224 to 2192±295 mmHg/sec, p〈0.001), dP/dt/P (from 32±8.1 to 50±17 sec−1; p〈0.0001), and in peak of systolic pressure (from 143±25 to 168±36 mmHg; p〈0.005). In addition, dobutamine reduced the end-systolic volume index (from 30±16 to 26±19 ml/m2; p〈0.05), the end-systolic stress (from 222.2±65.3 to 198.4±84 g/cm2; p〈0.006), and had favorable effects on relaxation and the early filling phase. The constant T (tau) significantly decreased (from 46±9 to 36±11 msec; p〈0.0001), while the left atrial left ventricular lowest pressure difference from 7.2±3.3 to 13.3±4.7 mmHg; p〈0.05), peak E velocity (from 0.52±0.08 to 0.65±0.18 m/sec; p〈0.05), and E velocity integral (from 12±3.2 to 15.39±6.10 cm; p〈0.05) significantly increased. In contrast, the late diastolic filling did not change. The positive effect of dobutamine on the diastolic phase might be explained by its mechanism at the subcellular level and by the reduction of both left ventricular end-systolic volume and end-systolic stress. We might conclude that in coronary artery disease patients with preserved systolic function dobutamine improves both relaxation and the early filling phase; these results add further information to the pharmacological effects of this drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00880155
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    Paper (German National Licenses)
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