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  • 1
    Electronic Resource
    Electronic Resource
    Plasma levels and myocardial content of verapamil, norverapamil and two N-dealkyl-metabolites in man (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 653-657 
    Details
    ISSN: 1432-1041
    Keywords: verapamil ; plasma levels ; myocardial uptake ; verapamil metabolites ; patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma levels and myocardial content of verapamil and its metabolites norverapamil, N-dealkylverapamil and N-dealkylnorverapamil were determined in 15 patients with valvular [3] or ischaemic [12] heart disease. The mean myocardial plasma concentration ratio (M/P) was 7.05 for verapamil, 11.45 for norverapamil, 8.93 for N-dealkylverapamil, and 11.33 for N-dealkylnorverapamil, with great interpatient variability. The highest M/P ratios of verapamil were generally found in patients with the lowest plasma levels, suggesting that saturable tissue uptake may occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607910
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  • 2
    Electronic Resource
    Electronic Resource
    Lupus vulgaris developing at the site of misdiagnosed scrofuloderma (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 17 (2003), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cutaneous tuberculosis is a rare form of extrapulmonary tuberculosis primarily occurring in developing countries. The recent increase in the incidence of tuberculosis, especially due to human immunodeficiency virus (HIV) infections, has led to a resurgence of extrapulmonary forms of this disease. We describe a case of lupus vulgaris in a 33-year-old woman who had a 5-year history of a slowly growing plaque on her neck. The lesion was located at the site of surgery repairing the scar resulting from the incision of a subcutaneous abscess during childhood. This lesion was misdiagnosed as bacterial abscess. Histopathologic examination of the plaque revealed non-caseating tuberculoid granulomas consisting of lymphocytes, epithelioid and giant cells. Staining for acid-fast bacilli and culture from biopsied tissue was negative. Polymerase chain reaction (PCR) for detection of Mycobacterium tuberculosis DNA, performed on a skin biopsy specimen, was positive. A diagnosis of lupus vulgaris developing at the site of a previous misdiagnosed scrofuloderma was made. Conventional antitubercular therapy with rifampicin, isoniazid and ethambutol was administered for 6 months, resulting in resolution of the lesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-3083.2003.00783.x
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  • 3
    Electronic Resource
    Electronic Resource
    Determination of 3,4-dihydroxyphenylethyleneglycol in urine by gas chromatography with a flame ionization detector: A new rapid method
    Amsterdam : Elsevier
    Clinica Chimica Acta 94 (1979), S. 155-161 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(79)90008-1
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  • 4
    Electronic Resource
    Electronic Resource
    Effect on electron energy on amorphization of ZrCr2 (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 729-733 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The influence of electron energy on the amorphization of ZrCr2 at 25 K was measured. Amorphization was observed at electron energies from 900 to 330 keV. The dose-to-amorphization increases with decreasing electron energy with two steps, one at 700 keV corresponding to the decrease in the Zr displacement cross section due to the approaching displacement threshold of Zr and one at 500 keV corresponding to an appreciable decrease in the displacement cross section of Cr due to the approaching displacement threshold for Cr. At lower electron energies, it is believed that amorphization occurs principally through a secondary displacement mechanism, where light impurity atoms (mainly O) are displaced by electrons and displace in turn the heavier atoms. By fitting the results using electron displacement cross sections, we find the displacement energies in each sublattice to be EdZr=22 eV, EdCr=23 eV, EdO=4 eV. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.362919
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  • 5
    Electronic Resource
    Electronic Resource
    Phleum pratense pollen starch granules induce humoral and cell-mediated immune responses in a rat model of allergy (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Timothy grass (Phleum pratense) pollen allergens are an important cause of allergic symptoms. However, pollen grains are too large to penetrate the deeper airways. Grass pollen is known to release allergen-bearing starch granules (SG) upon contact with water. These granules can create an inhalable allergenic aerosol capable of triggering an early asthmatic response and are implicated in thunderstorm-associated asthma.Objective We studied the humoral (IgE) and bronchial lymph node cells reactivities to SG from timothy grass pollen in pollen-sensitized rats.Methods Brown–Norway rats were sensitized (day 0) and challenged (day 21) intratracheally with intact pollen and kept immunized by pollen intranasal instillation by 4 weeks intervals during 3 months. Blood and bronchial lymph nodes were collected 7 days after the last intranasal challenge. SG were purified from fresh timothy grass pollen using 5 μm mesh filters. To determine the humoral response (IgE) to SG, we developed an original ELISA inhibition test, based on competition between pollen allergens and purified SG. The cell-mediated response to SG in the bronchial lymph node cells was determined by measuring the uptake of [3H]thymidine in a proliferation assay.Results An antibody response to SG was induced, and purified SG were able to inhibit the IgE ELISA absorbance by 45%. Pollen extract and intact pollen gave inhibitions of 55% and 52%, respectively. A cell-mediated response was also found, as pollen extract, intact pollen and SG triggered proliferation of bronchial lymph node cells.Conclusions It was confirmed that timothy grass pollen contains allergen-loaded SG, which are released upon contact with water. These granules were shown to be recognized by pollen-sensitized rats sera and to trigger lymph node cell proliferation in these rats. These data provide new arguments supporting the implication of grass pollen SG in allergic asthma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.01872.x
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  • 6
    Electronic Resource
    Electronic Resource
    Phase formation in Zr–Fe multilayers: Effect of irradiation (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 85 (1999), S. 7146-7158 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have conducted a detailed in situ study of phase formation in Zr–Fe metallic multilayers using irradiation and thermal annealing. Metallic multilayers with near equiatomic and Fe-rich overall compositions and with repetition thicknesses ranging from 7.4 to 33 nm were either irradiated with 300 keV Kr ions at various temperatures (from 17 to 623 K) or thermally annealed at 773 K while being observed in situ. The kinetics of multilayer reaction were monitored by following the diffraction patterns. For near equiatomic samples, irradiation causes complete amorphization. The dose to amorphization increases in proportion to the square of the wavelength, indicating a process controlled by atomic transport. Amorphization was also achieved by 900 keV electron irradiation at 25 K showing that displacement cascades are not required. The critical dose to amorphization was independent of temperature below room temperature and decreased above room temperature. The activation energy for this second process is 0.17 eV. For the temperature range studied, diffraction from Zr disappears first, indicating that amorphization takes place in the Zr layer by atomic transport of Fe from the Fe layers. These results are consistent with a combination of simple ballistic mixing at low temperature and either simple diffusion or radiation-enhanced diffusion at higher temperatures. Thermal annealing of the equiatomic samples at 773 K produced the same reaction products with slower kinetics. Ion irradiation of Fe-rich samples did not cause complete amorphization and intermetallic compounds Zr3Fe and ZrFe2 were observed in longer wavelength samples. Amorphization of Fe-rich samples was more sluggish, likely because there was competition with formation of other phases. The reaction kinetics were not proportional to square of wavelength for Fe-rich samples, indicating a process that depends on more than atomic transport. Thermal annealing at 773 K of a long wavelength, 57% Fe sample resulted in intermetallic compounds Zr3Fe and ZrFe2 which amorphized during subsequent irradiation. The ease of amorphization of equiatomic samples relative to Fe-rich samples can be explained by a narrower, single minimum free energy curve for the amorphous phase. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.370526
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  • 7
    Electronic Resource
    Electronic Resource
    Lifetime and diffusion length inhomogeneity controlled by point and extended defect interaction in n-GaAs LEC
    Amsterdam : Elsevier
    Applied Surface Science 63 (1993), S. 208-212 
    Details
    ISSN: 0169-4332
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0169-4332(93)90091-O
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  • 8
    Electronic Resource
    Electronic Resource
    Nuclear Overhauser effects in linear peptides A low-temperature 500 MHz study of Met-enkephalin
    Amsterdam : Elsevier
    FEBS Letters 215 (1987), S. 215-218 
    Details
    ISSN: 0014-5793
    Keywords: Conformation ; Cryoprotective mixture ; Met^5-enkephalin ; Nuclear Overhauser effect
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(87)80148-5
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  • 9
    Electronic Resource
    Electronic Resource
    Viscosity as a conformational sieve. NOE of linear peptides in cryoprotective mixtures
    Amsterdam : Elsevier
    Journal of Magnetic Resonance (1969) 95 (1991), S. 201-207 
    Details
    ISSN: 0022-2364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0022-2364(91)90339-U
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  • 10
    Electronic Resource
    Electronic Resource
    NOE measurements on linear peptides in cryoprotective aqueous mixtures
    Amsterdam : Elsevier
    Journal of Magnetic Resonance (1969) 75 (1987), S. 364-370 
    Details
    ISSN: 0022-2364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0022-2364(87)90044-8
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