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  • 1
    Electronic Resource
    Electronic Resource
    Diagnostics for TFTR neutral beam species measurement (1986)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 57 (1986), S. 2066-2068 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Five diagnostic systems were used for initial species measurements during tokamak fusion test reactor (TFTR) neutral beam test stand operations involving four ion sources, as well as several different configurations and operating conditions. Initial results were obtained for total neutral species fractions at the beamline input and the beamline output, differential radial profiles of species fractions, angular divergences of species components, species radial power density profiles, and beam impurity components for various conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1138740
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  • 2
    Electronic Resource
    Electronic Resource
    RISK-BENEFITS OF ANTIHYPERTENSIVE DRUGS - β-BLOCKERS (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 15 (1988), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. β-Blockers are of similar efficacy in the treatment of hypertension to other antihypertensive drugs of first choice; they have a wide spectrum of activity both alone and in combination.2. Although β-blockers first appear to worsen the haemodynamic changes of hypertension, subsequently peripheral resistance falls. The cardiovascular reflexes responsible for the responses of posture or other responses requiring normal functioning of α-mediated tone are not inhibited.3. Important contra-indications are asthma and heart failure in susceptible subjects. Lipid soluble drugs have somewhat greater CNS side effects.4. Triglyceride levels, notably an increase in VLDL and a fall in HDL occur from non-selective agents (less so from Pi-selective agents) and there is a marginal effect from drugs with relatively high ISA.5. In contrast to other antihypertensive drugs β-blockers reduce the myocardial infarction rate in high risk patients (i.e. post-myocardial infarct). Results in primary prevention of mild hypertension have been less promising.6. Those drugs which are lipid soluble and liver metabolized result in greater variation of plasma concentration after oral administration and some pharmacokinetic drug interactions. Once daily administration is possible with many β-blockers.7. β-Blocking drugs have an established and proven place in the treatment of hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1988.tb01063.x
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  • 3
    Electronic Resource
    Electronic Resource
    Birth in four cultures - by Brigitte Jordan . Eden Press Women's Publications, Montreal, 1980. 109 pp. 17 Plates
    Amsterdam : Elsevier
    Social Science & Medicine 17 (1983), S. 1928-1929 
    Details
    ISSN: 0277-9536
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0277-9536(83)90171-5
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of food on the absorption of hydralazine in man (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 53-58 
    Details
    ISSN: 1432-1041
    Keywords: hydralazine ; food ; absorption ; plasma level ; salivary level ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Single oral doses of hydralazine (Apresoline) 50 mg were administered on two occasions to eight healthy volunteers when fed and fasting. Blood and saliva samples were taken at intervals after dosing and analysed for drug. Heart rate and blood pressure were measured before and at intervals after dosing, at rest, after tilt and exercise. Plasma hydralazine levels showed wide inter-individual variation. The areas under the plasma concentration-time curve (0–8 h), the height of the peak plasma levels and the time to peak were not significantly different between the fed and fasting state. Salivary hydralazine levels were readily measurable but showed little correlation with plasma levels. The heart rate and pulse pressure were increased after drug both at rest, supine and erect, and after exercise for between 6 and 8 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554667
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of urapidil on responses to phenylephrine, angiotensin and isoprenaline in man (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 1-3 
    Details
    ISSN: 1432-1041
    Keywords: Urapidil ; phenylephrine ; angiotensin ; isoprenaline ; dose-response ; pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Intravenous urapidil, 40 mg bolus followed by an infusion of 18 mg·h−1 for 2 h was administered to 6 female non-patient volunteers. Randomised cumulative dose response curves to angiotensin, phenylephrine and isoprenaline were performed before and commencing 30 min after the start of the infusion of urapidil. Urapidil significantly reduced supine systolic blood pressure, 118.5 mm Hg to 105.3. The diastolic blood pressure was not significantly reduced, heart rate was not affected. Urapidil did not affect the responses to angiotensin or isoprenaline. Urapidil inhibited the pressor response to phenylephrine. The dose required to increase systolic blood pressure by 20 mm Hg increased from 156.9 μg·min−1 before to 685 μg·min−1 during urapidil; Dose ratio from individual values of 4.58. Urapidil concentrations were not significantly different before and after each agonist infusion. It is concluded that urapidil has α1-adrenoceptor blocking activity in man without any non specific vasodilator action and that it is devoid of beta adrenoceptor blocking action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280097
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  • 6
    Electronic Resource
    Electronic Resource
    Clinical pharmacology of carvedilol (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. S27 
    Details
    ISSN: 1432-1440
    Keywords: Carvedilol ; Clinical pharmacology ; Review ; Haemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Animal work has shown that carvedilol is a nonselective β-blocking drug. It has a vasodilator action from α-receptor blockade, but there is evidence that it has further action to relax smooth muscle, possibly from calcium channel antagonism. Carvedilol is lipid soluble and 25% bioavailable, and it has a half-life of about 7 h. It lowers blood pressure at rest and reduces the tachycardia and the rise of blood pressure on exercise. It reduces the level of blood pressure reached during isometric exercise or the cold pressor test. Cardiac output at rest is maintained, and the haemodynamics in the compromised heart is improved. It has an important peripheral vasodilator action, peripheral flow being maintained to important organs, e.g. kidneys, despite the fall in blood pressure. Exercising renin and noradrenaline levels are increased, as are the latter at rest. Carvedilol is lipid neutral. Carvedilol shifts the dose-response curve to isoprenaline to the right, as well as to α-stimulants such as phenylephrine. Responses to angiotensin are little affected. The ratio of β- to α-blockade has been found to be 7.6 for 50 mg and 12.5 for 100 mg of carvedilol. There is no evidence of a decline in α-blockade after 1 week of continuous administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00207608
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  • 7
    Electronic Resource
    Electronic Resource
    Bromocriptine in the treatment of hypertension (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 141-144 
    Details
    ISSN: 1432-1041
    Keywords: bromocriptine ; hypertension ; plasma prolactin ; double-blind study ; placebo ; plasma noradrenaline ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The efficacy of bromocriptine in the treatment of hypertension was assessed in a double-blind placebo controlled cross-over study preceded by a dose titration phase. A diuretic and/or a beta-blocker were administered concomitantly in constant dosage to 11 of the 20 patients who received bromocriptine. A wide range of doses of bromocriptine was tolerated. Side-effects of vomiting and postural hypertension did not occur, possibly due to the gradual increase in the administered doses. Plasma prolactin was not raised in this population of hypertensives. In the dose titration phase (n=20), a small fall in diastolic but not in systolic blood pressure occurred with bromocriptine, but only with the patient standing and after exercise. In the double-blind phase (n=9), there was no significant difference in blood pressure between the bromocriptine and placebo treatments. It is concluded that bromocriptine was not effective in lowering blood pressure in the present patients with essential hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614291
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  • 8
    Electronic Resource
    Electronic Resource
    Clinical experience with moxonidine (1994)
    Springer
    Cardiovascular drugs and therapy 8 (1994), S. 49-58 
    Details
    ISSN: 1573-7241
    Keywords: moxonidine ; hemodynamics ; pharmacokinetics ; comparative antihypertensive studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Moxonidine is an imidazoline receptor modulator, specific for the I1-imidazoline receptor. The stimulation of imidazoline receptors represents a new mode of antihypertensive action to inhibit peripheral alpha-adrenergic tone by a central mechanism. Acute hemodynamic studies reveal moxonidine produces an acute fall of blood pressure and systemic vascular resistance. Heart rate, cardiac output, stroke volume, and pulmonary artery pressures are not affected. Left ventricular end-systolic and diastolic volumes are reduced. Ejection fraction is not significantly affected but 6-month studies showed a regression of left ventricular hypertrophy. After oral administration the maximum concentration of moxonidine is reached in about 1 hour, and elimination half-life is 2.5 hours, prolonged by renal insufficiency. The antihypertensive effect lasts longer than would be expected from the half-life. Open studies with moxonidine have revealed falls between 20 and 29 mmHg systolic, and between 10 and 19 mmHg diastolic blood pressure. In the largest study, over 12 months in 141 patients, most patients were controlled by 0.2mg daily (58%) or 0.2 mg b.i.d. (38%). Moxonidine has been compared with representatives from each important class of antihypertensive drugs. In a crossover trial of clonidine in 20 patients, blood pressure control was similar, but the incidence of tiredness and dry mouth was less on moxonidine, as was the total number of patients experiencing side effects, 85% versus 30% (p〈0.01). In a larger parallel group study of moxonidine (n=122) and clonidine (n=30), blood pressure control was similar, but the overall incidence of side effects was less on moxonidine. In comparative studies of moxonidine with atenolol, ACE inhibitors, dihydropyridine calcium antagonists, hydrochlorothiazide, and α1 blockade, the blood pressure control with representatives of these various classes of drugs was similar to moxonidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00877084
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