ISSN:
1432-1238
Keywords:
Ventilator-associated pneumonia
;
Risk factors
;
Pseudomonas aeruginosa
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objective to investigate the epidemiology of infection byPseudomonas aeruginosa in patients with ventilator-associated pneumonia (VAP). Design prospective clinical study. Setting a medical-surgical ICU in a university hospital. Patients we followed-up 568 mechanically ventilated patients and 83 episodes of VAP with etiologic diagnosis in 72 patients were retained for analysis. Results Ps. aeruginosa was isolated in 22 (26.5%) episodes in 18 patients. Of these episodes 7 were directly responsible for death. Using logistic regression analysis, the risk of VAP due toPs. aeruginosa was increased in patients with chronic obstructive pulmonary disease (relative risk (RR)=29.9, 95% confidence interval (CI)=4.86-184.53), a mechanical ventilation period longer than 8 days (RR=8.1, 95% CI=1.01-65.40) and prior use of antibiotics (RR=5.5, 95% CI=0.88-35.01). Conclusions patients with VAP and these factors have a greater risk of infection byPs. aeruginosa and empirical therapy for these episodes should include anti-pseudomonal activity until etiologic diagnosis is established.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01704699
Permalink
