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  • 1
    Electronic Resource
    Electronic Resource
    Stroke and minute distance in pregnancy: a longitudinal study using Doppler ultrasound (1987)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 94 (1987), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Using Doppler ultrasound directed at the aortic arch, stroke and minute distance were measured in 45 normal singleton pregnancies and compared with 42 controls. In the non-pregnant controls, stroke distance was 5% more in the supine than in the left lateral position (P〈0·01) and during pregnancy this relativity was maintained until 36 weeks gestation. In the supine and left lateral positions respectively, stroke distance was increased by 8% (both) at 4 weeks (P〈0·05 and NS), by 14 and 11% at 8 weeks (P〈0·001 and P〈0·01) and showed a maximum increase of 21 and 20% at 16 weeks gestation (both P〈0·001). At 40 weeks, supine stroke distance was 14% less than the non-pregnant control value (P〈0·001), and 6% less than the value in the left lateral position (P〈0·05), which was itself not significantly different from that in the non-pregnant controls. The maximum increase of heart rate was at 32 weeks, by 24% in the supine and by 19% in the left lateral position (both P〈0·001). Minute distance was maximally increased by 37% in the supine at 16 weeks (P〈0·001) and by 30% in the left lateral position at 24 weeks (P〈0·001). Thereafter, minute distance, measured in both positions, declined until at 40 weeks it was not significantly different from the non-pregnant control value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1987.tb03140.x
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of position and delay on stroke and minute distance in late pregnancy (1987)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 94 (1987), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Stroke and minute distance were measured in 12 women in late pregnancy using Doppler ultrasound. In each patient two sets of measurements were made every 2 min for 20 min in the supine and left lateral positions, the sequence of positions being reversed on the second occasion. Within each of the four 20 min measurement periods there were no significant changes with time in stroke distance, heart rate, or minute distance, or in their coefficients of variation. From this evidence there is no justification for delaying the measurement of cardiac output until a 'steady state’is reached. The measurements were influenced both by the sequence and the position in which they were taken, the effects being additive. Overall, stroke distance was 5·1% greater in the left lateral than in the supine position, heart rate was 3·7% less and minute distance not significantly different. Independent of posture, stroke distance was 6·5% greater in the second period of measurement than in the first, heart rate was 3% less and minute distance 2·8% more. In late pregnancy the relative magnitude of cardiac output in the left lateral and supine positions has to be interpreted in the light of a stepwise increase of aortic blood flow with change of posture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1987.tb03141.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Accelerated increase in aortic diameter in patients treated for lymphoma (1988)
    Springer
    Heart and vessels 4 (1988), S. 237-240 
    Details
    ISSN: 1615-2573
    Keywords: Thoracic aorta ; Malignant lymphoma ; Cytotoxic chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cytotoxic chemotherapeutic agents, particularly the anthracyclines, are known to be cardiotixic, but toxic effects on the aorta have not previously been documented. In this study, diameters of ascending and descending thoracic aortae were measured by computerized tomography in 69 patients with lymphoma, before and after first-line treatment with one of 7 different regimes. Minor increases in aortic diameter over the study period due to the aging process were expected. These increases were greater than anticipated in both the ascending and the descending aortae after chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) and CVP (cyclophosphamide, vincristine, and prednisolone) regimes. Smaller changes, or changes which were not statistically significant, were noted after MVPP (mustine, vinblastine, procarbazine, and prednisolone), ChlVPP (chlorambucil, vinblastine, procarbazine, and prednisolone), ChlVP (chlorambucil, vincristine and prednisolone), mediastinal radiotherapy, and radiotherapy plus MVPP (MVPP/XRT). Cardiovascular damage associated with certain forms of cytotoxic therapy is not confined to the heart, but also affects the aorta.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058592
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    Paper (German National Licenses)
    Fulltext
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