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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of the Release of Exogenous and Endogenous Excitatory Amino Acids from Rat Cerebral Cortex (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 648 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb24583.x
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  • 2
    Electronic Resource
    Electronic Resource
    Improved method for the determination of sulphate in human serum using ion chromatography
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 413 (1987), S. 251-256 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-4347(87)80235-9
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  • 3
    Electronic Resource
    Electronic Resource
    Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the α-chain of the human interleukin-2 receptor
    Amsterdam : Elsevier
    Gene 121 (1992), S. 271-278 
    Details
    ISSN: 0378-1119
    Keywords: Recombinant DNA ; antigen modulation ; complement activation ; mAb cocktail ; mixed lymphocyte reaction ; transfectoma technology
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(92)90131-8
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  • 4
    Electronic Resource
    Electronic Resource
    Treatment of Rheumatoid Arthritis with a Chimeric CD4 Monoclonal Antibody (cM-T412): Immunopharmacological Aspects and Mechanisms of Action (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 39 (1994), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To investigate the mechanisms of action underlying the therapeutic effect of CD4 monoclonal antibody therapy in rheumatoid arthritis (RA), clinical responses were compared with several laboratory parameters. Twenty-nine RA patients received either 10 mg, 50 mg or 100 mg of cM-T412, a chimeric CD4 MoAb, for 7 days. The CD4 binding sites on circulating lymphocytes were saturated directly with cM-T412 and serum levels of unbound cM-T412 accumulated towards day 7 of treatment only in the patients treated with 50 and 100 mg. The treatment induced an instant and prolonged depression of the number of circulating CD4+ cells, similar for all dosages. Clinical improvement was observed predominantly in the patients treated with 50 or 100mgcM-T412daily and did not correlate with changes in counts of circulating leucocyte subsets nor with changes in serum cytokine levels. An antiglobulin response against cM-T412 developed in a majority of the patients. Side effects on the first day of treatment were correlated with an increase of serum IL-6 levels. This study indicates that a favourable clinical effect of cM-T412 administration was associated with the presence of unbound cM-T412 in the circulation of RA patients. Therefore penetration of unbound cM-T412 into the site of inflammation might determine the therapeutic effect in RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1994.tb03373.x
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of calcitonin gene-related peptide in the central nervous system of the lizard; Laceria muralis
    Amsterdam : Elsevier
    Regulatory Peptides 34 (1991), S. 104 
    Details
    ISSN: 0167-0115
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(91)90424-F
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  • 6
    Electronic Resource
    Electronic Resource
    The ratio of acetylcholinesterase to butyrylcholinesterase influences the specificity of assays for each enzyme in human brain (1989)
    Springer
    Journal of neural transmission 75 (1989), S. 129-134 
    Details
    ISSN: 1435-1463
    Keywords: Acetylcholinesterase ; butyrylcholinesterase ; Alzheimer's disease ; brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A single-vial extraction radiometric assay was used to measure acetylcholinesterase and butyrylcholinesterase in human post-mortem brain tissue. Data are presented regarding the differential inhibition of acetylcholinesterase and butyrylcholinesterase in several brain areas from a case of Alzheimer's disease and a case without neuropsychiatrie disease. The results indicate that neither enzyme is entirely specific for its substrate, and the necessity for using inhibitors depends upon the ratio of acetylcholinesterase to butyrylcholinesterase in a particular sample.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01677426
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  • 7
    Electronic Resource
    Electronic Resource
    Bemerkungen zur Morphologie forensisch bedeutsamer Fliegenmaden (1982)
    Springer
    International journal of legal medicine 89 (1982), S. 197-206 
    Details
    ISSN: 1437-1596
    Keywords: Time of death ; Maggots, morphology and life-cycles ; Todeszeitbestimmung ; Fliegenmaden, Morphologie und Entwicklung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Bei der Begutachtung des Todeszeitpunktes können bei Anwendung entomologischer Methoden vor allem im Hinblick auf das Erkennen und Bestimmen unterschiedlicher Fliegen und ihrer Maden —vornehmlich der Familien Calliphoridae, Muscidae und Sarcophagidae —wertvolle Informationen gewonnen werden. Die Kenntnis der Entwicklungsabläufe und Lebensweise cyclorrhapher Fliegen (z.B. Schmeißfliegen, Stubenfliegen und Fleischfliegen) sowie der morphologischen Eigentümlichkeiten ihrer Maden stellt die Grundlage forensisch entomologischer Tätigkeit dar.
    Notes: Summary For medico-legal purposes, usually as an aid in establishing the time of death, it is considered essential for forensic pathologists to have detailed entomological knowledge regarding the recognition and classification of several types of flies and their maggots, including the families of Calliphoridae, Muscidae and Sarcophagidae. We try to deal with the description of external and internal morphology of cyclorrhaphous maggots, the biology and lifecycles of blowflies, houseflies and fleshflies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01873802
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  • 8
    Electronic Resource
    Electronic Resource
    Zur Artbestimmung der Maden forensisch bedeutsamer Schmeißfliegen (1983)
    Springer
    International journal of legal medicine 90 (1983), S. 309-316 
    Details
    ISSN: 1437-1596
    Keywords: Maggots of blow-flies, determination of species ; Classification key, maggots of blow-flies ; Schmeißfliegenmaden, Artbestimmung ; Bestimmungsschlüssel, Schmeißfliegenmaden
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Morphologie des Kieferapparates und des 12. Madensegmentes sowie die Ausgestaltung der vorderen Atemöffnungen konnten im Zusammenwirken als sichere Parameter zur Artbestimmung forensisch bedeutsamer Schmeißfliegen nachgewiesen werden. Die wichtigsten Artmerkmale der Maden werden in einem Bestimmungsschlüssel aufgelistet.
    Notes: Summary The morphology of the cephalopharyngealsklerite, the 12th segment of the maggot and the anterior respiratory openings together provide useful recognition features to distinguish the maggots of forensically important blow-fly species. The significant characters of the maggots are finally collected in a classification key.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02116206
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  • 9
    Electronic Resource
    Electronic Resource
    Chromolipidspeicherung in Alveolarmakrophagen: Ein Agnoszierungsmerkmal für Zigarettenraucher (1983)
    Springer
    International journal of legal medicine 91 (1983), S. 37-46 
    Details
    ISSN: 1437-1596
    Keywords: Smokers, histological identification ; Alveolar macrophages, inclusion of ceroid-like pigments in smoker lungs ; Zigarettenraucher, mikroskopische Identifizierung ; Alveolarmakrophagen, Chromolipideinschlüsse bei Rauchern
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Histologische und cytologische Untersuchungen von 188 Leichen — 113 Raucher und 75 Nichtraucher — ergaben, daß Zigarettenrauch zur Vermehrung und Vergrößerung der Alveolarmakrophagen führt, welche ceroidartige Pigmenteinlagerungen enthalten. Akuter Verbrennungstod, protrahiertes Ersticken oder Fäulnis haben keinen Einfluß auf die Entstehung der sudanophilen Einschlüsse. Sie erweisen sich u. a. resistent gegenüber autolytischen Veränderungen und Lipidlösungsmittel. Nach Anfertigung von Paraffinschnitten des Lungengewebes und anschließender Fettfärbung können Raucher selbst nach mehrmonatiger Liegezeit im Erdgrab noch eindeutig identifiziert werden.
    Notes: Summary Histological and cytological examinations of 188 autopsies-113 smokers and 75 non-smokers-established that cigarette smoke causes increase and multiplication of alveolar macrophages which contain inclusions of ceroid-like pigment. Acute death by fire, delayed asphyxia and putrefaction have no influence on the formation of these sudanophilic inclusions. The pigment is resistant to decomposition and lipid-solvents. It is possible to identify cigarette-smokers-even months after burial—by means of paraffin sections of lung tissue and proceeding with fat—staining methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01882447
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  • 10
    Electronic Resource
    Electronic Resource
    Zur Artbestimmung der Puparien forensisch bedeutsamer Schmeißfliegen (1983)
    Springer
    International journal of legal medicine 91 (1983), S. 61-69 
    Details
    ISSN: 1437-1596
    Keywords: Forensic entomology ; Blow-fly puparia, key to the species ; Forensische Entomologie ; Schmeißfliegenpuparien, Artbestimmung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Morphologie des Kieferapparates sowie des 12. Pupariensegmentes konnten als aussagekräftige Merkmale zur Artbestimmung forensisch bedeutsamer Schmeißfliegenpuparien nachgewiesen werden. Die Größe der Puparien bietet höchstens orientierende Hinweise auf die Fliegenart. Zusammenfassend werden die wichtigsten Merkmale der Puparien in einem Bestimmungsschlüssel aufgelistet.
    Notes: Summary The cephalopharyngealsclerite and the morphology of the 12th puparian segment provide useful recognition features to distinguish the puparia of forensically important blow-fly species. In addition it was found that the size of the puparia can only make restricted reference to the identification of the species. The most useful characters of the puparia are finally collected in a classification key.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01882449
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