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  • 1
    Electronic Resource
    Electronic Resource
    Posterpräsentation (1995)
    Springer
    Archives of gynecology and obstetrics 256 (1995), S. S228 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02201966
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    VATS-guided epicardial pacemaker implantation (1997)
    Springer
    Surgical endoscopy and other interventional techniques 11 (1997), S. 1167-1170 
    Details
    ISSN: 1432-2218
    Keywords: Key words: VATS — Hand suture — Pacemaker implantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In neonates and infants epicardial stimulation may be preferred to endocardial stimulation because of growth-associated lead problems and the risk of vascular complications associated with transvenous electrodes. This study analyzes the feasibility of atrioventricular implantation of a new epicardial lead using the video-assisted thoracic surgical (VATS) technique in an animal model. Methods: Bipolar steroid-eluting epicardial leads were implanted in seven young white pigs. In five animals bipolar atrial and ventricular pacing leads (n= 10) were inserted and fixed by the VATS technique, while two animals served as controls and underwent implantation through anterolateral thoracotomy. Surgical feasibility, pacing, and sensing thresholds of the leads as well as hemodynamic parameters during pacing were studied. Histological changes beneath the electrodes were evaluated 1 week after the implantation. Results: All animals survived the pacemaker lead implantation. One animal which underwent thoracotomy died because of irreversible ventricular fibrillation induced by rapid ventricular pacing. One animal in the VATS group exhibited intraoperative herniation of the heart through the pericardial window. All animals with left-sided VATS implantations demonstrated good individual pacing and sensing threshold values. The mean cardiac output was 1.6 times higher during AAI-mode pacing as compared to VVI-mode pacing at a heart rate of 140/min. One animal died postoperatively due to respiratory failure. No displacements of the pacemaker leads were observed in the survivors. Conclusion: While VATS-guided implantation of epicardial, atrial, and ventricular leads is feasible, technical improvements of the system are mandatory for safe clinical application.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649900562
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Video-assisted mediastinal lymph node dissection assessed in an experimental setting (1996)
    Springer
    Surgical endoscopy and other interventional techniques 10 (1996), S. 128-132 
    Details
    ISSN: 1432-2218
    Keywords: VATS ; Mediastinal lymph node ; Endoscopic dissection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Feasibility, completeness, and morbidity of videoscopic-assisted mediastinal lymph node dissection (VATS MLND) were compared to the standard surgical technique in an experimental study. Methods: Right upper MLND—together with upper lobectomy in half of the cases—was performed in ten large white pigs. Six animals were operated using VATS (group 1), four using conventional open techniques (group 2). After 1 week, the animals were sacrificed and the mediastinum was assessed for remaining lymph nodes. Results: All animals survived without intra- or post-operative complications. There was no significant difference in the operation time between the two groups (3.2±0.8 vs 3.2±0.2 h). The number of mediastinal lymph nodes harvested was 9.5±2.7 in group 1 and 11.5±0.5 in group 2 (n.s.). The post-mortem assessment of the mediastinum showed in two animals of group 1 and in two animals of group 2 that one lymph node was left behind. In addition, in one animal of group 1 four small retrotracheal lymph nodes were found. Conclusions: VATS MLND can be accomplished without morbidity and is as radical as that achieved with conventional surgery in the paratracheal and peribronchial areas in this experimental setting. However, retrotracheal lymph node dissection might not be as complete as achieved by conventional surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00188357
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  • 4
    Electronic Resource
    Electronic Resource
    mTHPC Polymer Conjugates: The In Vivo Photodynamic Activity of Four Candidate Compounds (1999)
    Springer
    Lasers in medical science 14 (1999), S. 40-46 
    Details
    ISSN: 1435-604X
    Keywords: Keywords: Meso substituted porphyrins; Mouse tumour; Photodynamic therapy; Poly(ethylene glycol); Tempoporfin (mTHPC)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. The in vivo photodynamic activities of four poly(ethylene glycol) (PEG) conjugates of the photosensitiser 5,10,15,20-tetrakis-(m-hydroxyphenyl)chlorin (mTHPC, temoporfin, Foscan®) were compared with that of mTHPC over a range of drug–light intervals using acute tumour necrosis and skeletal muscles swelling in a mouse model in order to ascertain the influence of linking group stability and PEG chain length on the photodynamic activity. The four compounds examined contained either PEG 2000 or PEG 5000 attached by carbonate or triazine linkages at the phenol hydroxyl groups of the mTHPC. All compounds tested caused tumour necrosis at drug–light intervals of between one and four days. mTHPC produced tumour necrosis of over 5 mm at drug–light intervals of 1 and 2 days with limited muscle damage at early drug–light intervals. The relatively labile carbonate-linked conjugates gave tumour necrosis similar to mTHPC but produced severe muscle and systemic phototoxicity on irradiation at 4–24 h after injection. The more stable triazine-linked conjugates produced no significant muscle damage at any of the drug–light intervals tested, but gave only limited tumour necrosis under the conditions tested. PEG chain length had relatively little effect on the patterns of bioactivity. It is concluded that both classes of mTHPC PEG conjugates may be suitable for photodynamic therapy if the problems of stability and early photosensitivity in the case of the carbonates and reduced potency in the case of the triazines can be overcome through improved formulations and PDT treatment regimens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101030050019
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Determination of 5,10,15,20-tetra-(m-hydroxyphenyl) chlorin in tissues by high performance liquid chromatography (1993)
    New York, NY : Wiley-Blackwell
    Biomedical Chromatography 7 (1993), S. 155-157 
    Details
    ISSN: 0269-3879
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A procedure for the extraction and high performance liquid chromatographic (HPLC) determination of the photodynamic therapeutic agent 5,10,15,20-tetra(m-hydroxyphenyl)chlorin in human, rat and mouse tissues following intravenous administration of the drug is described. The tissue (tumour, skin, muscle and liver) was homogenized and extracted into a mixture of methanol:dimethyl sulphoxide:water (32:8:1 by vol.) containing, 5,10,15,20-tetra(p-hydroxyphenyl)chlorin as the internal standard. The precipitated proteins were removed by centrifugation and the supernatant was separated by reversed phase HPLC on a Hypersil-ODS column with 77% (v/v) acetonitrile in 0.1% trifluoroacetic acid as the mobile phase. The solute was detected with high sensitivity and specificity by a UV-VIS detector set at 423 nm.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bmc.1130070311
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    Paper (German National Licenses)
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