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  • 1
    Electronic Resource
    Electronic Resource
    Caclium causes the biphasic dose-response curve for pancreatic amylase secretion (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 256-257 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary High concentrations of bethanechol (10−4 to 10−3 M) were effective stimulants of amylase secretion from the mouse pancreas if incubations are performed in low [ca2+] (0.1 mM) solutions but not if normal Krebs solution (2.56 mM Ca2+) was used. This inhibitory effect of Ca2+ at high secretagogue concentrations did not appear to be mediated through the microtubules or microfilaments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945098
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  • 2
    Electronic Resource
    Electronic Resource
    Membrane potential and resistance changes induced in salivary gland acinar cells by microiontophoretic application of acetylcholine and adrenergic agonists (1978)
    Springer
    The journal of membrane biology 39 (1978), S. 297-312 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The effects of microiontophoretic applications of catecholamines and acetylcholine on parotid acinar cell membrane potential and resistance were investigated using intracellular microelectrode recording in superfused segments of mouse parotid or rat submandibular glands. Short pulses of acetylcholine and α-adrenergic agonists had similar effects, consisting of a marked decrease in membrane resistance accompanied by an initial depolarization or hyperpolarization depending on the level of the resting membrane potential. This initial response was followed by a slow hyperpolarization occurring at a time when the resistance was increasing towards the prestimulation level. The equilibrium potential for the initial potential change caused by excitation of the cholinergic receptors was investigated directly by setting the membrane potential at different levels by injecting direct current and stimulating the same cell repeatedly with equal doses of acetylcholine. The equilibrium potential was found to be about −55 mV. The delayed hyperpolarization could not be reversed by passing hyperpolarizing current, but actually increased in size with higher membrane potentials. The minimum latency of the effect of acetylcholine or α-adrenergic agonists was 200–500 msec. Excitation of β-adrenoceptors caused, after a long latency of several seconds, a small depolarization. Epinephrine induced a combined α- and β-adrenergic response, with the α-component predominating. Blocking the α-adrenoceptors with phentolamine revealed the β-adrenergic depolarization, while blocking the β-adrenoceptors with propranolol caused the components of the α-adrenergic response to become more pronounced. All three receptors (α- and β-adrenoceptors and cholinergic receptors) were present in individual acini.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01869896
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  • 3
    Electronic Resource
    Electronic Resource
    Multidimensional phase space and sunset diagrams (2001)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 42 (2001), S. 5553-5564 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: We derive expressions for the phase space of a particle of momentum p decaying into N particles, that are valid for any number of dimensions. These are the imaginary parts of so-called "sunset" diagrams, which we also obtain. The results are given as a series of hypergeometric functions, which terminate for odd dimensions and are also well suited for deriving the threshold behavior. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1416887
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  • 4
    Electronic Resource
    Electronic Resource
    Lymphoproliferative responses in diet-restricted and aging Sprague-Dawley rats
    Amsterdam : Elsevier
    Experimental Gerontology 27 (1992), S. 201-209 
    Details
    ISSN: 0531-5565
    Keywords: aging ; dietary restriction ; lymphocytes ; mitogens ; rats
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0531-5565(92)90044-Z
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  • 5
    Electronic Resource
    Electronic Resource
    The in vitro secretion of epidermal growth factor by mouse submandibular salivary gland (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 296 (1977), S. 301-305 
    Details
    ISSN: 1432-1912
    Keywords: Epidermal growth factor ; Secretion ; α-Receptor agonists ; Colchicine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A technique for the study of epidermal growth factor (EGF) secretion from salivary gland pieces in vitro is described and the responses to a variety of drugs are compared to the results of previously reported in vivo studies. Adrenaline stimulates secretion of the growth factor as does the α-adrenergic agonist phenylephrine, while isoprenaline is less active in stimulating EGF secretion. Phentolamine, but not propranolol, blocks the secretory activity of adrenaline and isoprenaline in this system. Pretreatment of the salivary gland pieces with colchicine reduces the secretory response to adrenaline, suggesting an involvement of microtubular proteins in the process. It is anticipated that the in vitro technique described will provide a means by which detailed investigation of the secretion of epidermal growth factor can be made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498698
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  • 6
    Electronic Resource
    Electronic Resource
    Parotid acinar cells: ionic dependence of acetylcholine-evoked membrane potential changes (1978)
    Springer
    Pflügers Archiv 376 (1978), S. 159-167 
    Details
    ISSN: 1432-2013
    Keywords: Parotid ; Acetylcholine ; Null potential ; Intercellular coupling ; Electrogenic Na pump
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Segments of mouse parotid were placed in a superfusion chamber. Surface acini were impaled by one or two micro-electrodes for measurement of membrane potential and resistance. The acinus under investigation was stimulated by micro-iontophoretic application of acetylcholine (ACh) or adrenaline. Neighbouring acinar cells were electrically coupled. Electrical coupling between acinar cells only occurred within restricted domains probably corresponding to an acinus or a group of acini. Passing direct current through one intracellular electrode, the resting potential of an acinus could be set at desired levels and the dependency of the ACh-evoked potential change on the resting potential investigated. The ACh null potential (initial effect) was about −60mV. A delayed hyperpolarizing effect of ACh could not be reversed. The initial ACh-evoked potential change was sensitive to alterations in extracellular Na, K and Cl concentration. The delayed ACh-evoked hyperpolarization was blocked by ouabain, exposure to Na-free or K-free solutions. It is concluded that ACh increases mainly K and Na membrane conductance causing K efflux and Na influx with a subsequent Na activation of an electrogenic Na pump.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581579
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  • 7
    Electronic Resource
    Electronic Resource
    Calcium Bioavailability and Parathyroid Hormone Acute Changes after Oral Intake of Dairy and Nondairy Products in Healthy Volunteers (1999)
    Springer
    Osteoporosis international 10 (1999), S. 137-142 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Bioavailability – Calcium – Citrate – Dairy – PTH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: This study was designed to compare calcium bioavailability and serum parathyroid hormone acute changes after oral intake of 500 mg of elemental calcium from liquid milk, yogurt, calcium-citrate-enriched powdered milk or a calcium carbonate pill; or after intake of soybean imitation-milk. After a 12-h fast, blood samples were drawn both at baseline and 1, 2, 3 and 4 h after an oral intake of the above-mentioned products, which were ingested together with a light neutral breakfast. The administration order of the study products was randomly assigned to each of 19 healthy young volunteers (11 females, 8 males). The baseline serum concentrations of ionized calcium, phosphorus and intact parathyroid hormone (iPTH) were normal. Calcium-citrate-enriched powdered milk induced a significant increase in serum ionized calcium (p〈0.001) and a significant and continuous decrease in serum iPTH concentration (p〈0.001). Yogurt and the calcium carbonate pill induced a similar but less significant effect, increasing serum ionized calcium (p〈0.05) and decreasing serum iPTH (p〈0.01). Liquid milk only induced a significant change in serum ionized calcium and iPTH concentration during the first 2 h; this effect was lost during the following 2 h. In conclusion, our study suggests the possibility that the addition of calcium citrate to powered milk may improve calcium bioavailability and enhance the inhibitory effect on serum iPTH in the assayed conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050208
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  • 8
    Electronic Resource
    Electronic Resource
    Comparisons of vector analyzing-power data and calculations for neutron-deuteron elastic scattering from 10 to 14 MeV (1987)
    Springer
    Few body systems 2 (1987), S. 19-32 
    Details
    ISSN: 1432-5411
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract High-accuracy analyzing-powerA y(θ) data forn-d elastic scattering at 12 MeV have been measured using the polarized-neutron facilities at the Triangle Universities Nuclear Laboratory (TUNL). The present data have been combined with our previousn-d measurements at 10, 12, and 14.1 MeV to form the highest-accuracyA y(θ) data set forn-d elastic scattering below 20 MeV. These data are compared to recent Faddeev-based neutron-deuteron (n-d) calculations which use the Paris and Bonn equivalent separable potentials PEST and BEST, as well as Doleschall's representation of theP- andD-wave nucleon-nucleon interactions. None of these models adequately describe the data in the angular region around the maximum ofA y(θ). Possible reasons for the discrepancies are discussed. The sensitivity of the present Faddeev-based calculations to various angular momentum components of the nucleon-nucleon interaction are examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01078989
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  • 9
    Electronic Resource
    Electronic Resource
    A feasibility study for a linac-based transuranic waste characterization system (1995)
    Springer
    Journal of radioanalytical and nuclear chemistry 193 (1995), S. 369-375 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Remote-handled transuranic nuclear waste poses a particular challenge for assaying due to the high neutron and γ-ray background that emanate from the non-fissile, but highly radioactive material, contained within the waste. The utilization of a Radio Frequency Quadrupole (RFQ) linac with a neutron flux of the order of 1010 n/s/4π has shown that, in principle, the differential die-away technique can be used to reliably assay this special class of nuclear waste.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02039894
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