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  • 1
    Electronic Resource
    Electronic Resource
    T6+ and HLA-DR+ cell numbers in epidermis of immunosuppressed renal transplant recipients (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 14 (1987), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The increased susceptibility of the skin of chronically immunosuppressed individuals to viral infections and sunlight-induced malignancies suggests specific drug-induced, dysfunction of local immune mechanisms within the sun-exposed skin of these individuals. To help understand the effect of immunosuppressive therapy alone in the absence of ultraviolet light on the immune system of skin, biopsies were collected from non-sun-exposed buttock skin of control, healthy volunteers and kidney transplant recipients immunosuppressed with either azathioprine/ prednisone or cyclosporin A/prednisone and examined for incidences of T6+, and HLA-DR+ cells. No significant differences in the incidences of these 2 cell types were found (a) between control individuals and transplant recipients, (b) between transplant recipients receiving either of the immunosuppressive drug regimes, or (c) between transplant recipients who either had or had not developed skin cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1987.tb01333.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    EFFECTS OF EXPOSURE TO ULTRAVIOLET LIGHT IN A COMMERCIAL SOLARIUM ON LANGERHANS CELLS AND MELANOCYTES IN HUMAN EPIDERMIS (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Australasian journal of dermatology 27 (1986), S. 0 
    Details
    ISSN: 1440-0960
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Nine subjects of Celtic and mixed European descent were exposed to small (1/2 hour) doses of ultraviolet light (UVL) on 10 consecutive days in a commercial solarium to determine the effects of UVL on epidermal melanocytes and immunocompetent Langerhans cells (LCs). Tanned and non-tanned subjects were studied to determine whether pigmentation from melanocytes provided the LCs with any protection against these UVL effects. A transient reduction in the number of LCs occurred in response to UVL exposure, returning to near pre-exposure levels two weeks after cessation of the solarium course. The tan which developed or deepened following the UVL exposure appeared to provide little or no protection against this reduction, regardless of whether the subjects were lightly tanned or untanned prior to the solarium course. Even though the number of subjects examined was small these results indicate that exposure to solarium UVL irradiation, even in small doses, may adversely affect the skin immune system and therefore is not recommended as a safe means of acquiring a tan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-0960.1986.tb00283.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    LANGERHANS CELL AND MELANOCYTE DISTRIBUTION IN “NORMAL” HUMAN EPIDERMIS (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Australasian journal of dermatology 24 (1983), S. 0 
    Details
    ISSN: 1440-0960
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Langerhans cells and melanocyte distribution was determined in 18 different body sites in 76 cadavers, 44 men and 32 women, within 24 hours of death. The Langerhans cell and melanocyte counts were inversely related so that in sun-exposed (tanned) epidermis Langerhans cell numbers were lower and melanocyte numbers were higher than in non-exposed (non-tanned) epidermis. Langerhans cell and melanocyte densities were similar in men and women on non-exposed (non-tanned) epidermis when matched by age. In any one subject Langerhans cell densities were even throughout the body except on sun-exposed (tanned) areas, where Langerhans cell counts were not only significantly lower but the cells were also unevenly distributed. Langerhans cell counts for all body areas decreased with age in both men and women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-0960.1983.tb00241.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructural changes in epidermal Langerhans cells and melanocytes in response to ultraviolet irradiation, in Australians of Aboriginal and Celtic descent (1988)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 119 (1988), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of exposure to small doses of artificial ultraviolet radiation (UVR) on the ultrastructure of epidermal Langerhans cells (LC) and melanocytes were studied in two groups of Australian subjects, one of Aboriginal and the other of Celtic descent.UV exposure induced an apparent depletion of LC in the epidermis of both groups. However, LC depletion in the Aboriginal subjects was associated with apoptosis, whereas organelle and membrane disruption in the LC of Celtic subjects suggested a reduction by direct cellular damage. LC in Aboriginal epidermis tended to become relocated at more superficial levels following UV exposure, and their Birbeck granules became more numerous. LC in Celtic epidermis appeared to become relocated in a basal location and contained fewer Birbeck granules. The central lamina of the Birbeck granules in Aboriginal LC, which was more electron-dense than that in Celtic subjects prior to UV treatment, was temporarily lost following treatment, while the ultrastructure of Birbeck granules in Celtic LC was unchanged. LC and ‘indeterminate cells’ in intimate association with lympocyte-like cells occurred in the basal layer of Celtic epidermis 5 days after exposure. These complexes were not observed in Aboriginal epidermis although isolated lymphocyte-like cells were observed in the same location.Melanocytes in Aboriginal epidermis contained greater numbers of melanosomes than those in Celtic epidermis throughout the experiment. Inactive epidermal melanocytes in Celtic subjects initially responded to UV exposure with a slight increase in melanosome content followed by a substantial further increase, whereas active melanocytes in the Aboriginal subjects showed the opposite response.The implications of the different responses of LC and melanocytes in the two groups, in relation to immunological function of the epidermis and the marked racial difference in the incidence of skin cancer, are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1988.tb07097.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    CORRESPONDENCE (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Australasian journal of dermatology 25 (1984), S. 0 
    Details
    ISSN: 1440-0960
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-0960.1984.tb00635.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    MULTIPLE PRIMARY MELANOMA — A REVIEW OF 90 CASES (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Australasian journal of dermatology 23 (1982), S. 0 
    Details
    ISSN: 1440-0960
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a restrospective study of 3,128 patients with primary melanoma, 90 were found to have more than one primary lesion, an incidence of 2.9%. Wherever possible, comparisons were made between single and multiple primary lesion patients with reference to age. Sex, racial background, skin, hair, eye colouring, distribution and characteristics of the primary melanoma lesions. Patients with one melanoma had a greater risk of developing another and their skin appeared to be more susceptible to sun damage. Patients with multiple abnormal pigmented naevi also had an increased risk of developing a second primary melanoma. Having one primary lesion tended to alert both patient and doctor and resulted in earlier diagnosis of the second lesion. Although these patients developed multiple melanomas, their prognosis was more favourable than in patients with a single primary melanoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-0960.1982.tb00230.x
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