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  • 1
    Digitale Medien
    Digitale Medien
    Long-term effect of gluten restriction on bone mineral density of patients with coeliac disease (1997)
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Aim: To assess the long-term effect of a gluten-free diet on bone mineral density of adults with untreated coeliac disease. Methods: Bone mineral density was assessed at baseline and after a mean duration of 37 months of treatment in 25 unselected newly diagnosed coeliac patients. Results: At baseline, osteopenia (〉−1 s.d. below normal) was evident in the lumbar spine and total skeleton in 18 (72%) and 21 (84%) patients, respectively. At the end of the study, bone density had increased (mean bone mass Z-score increase: Z-score +1.0 for the lumbar spine and +1.1 for total skeleton) in 22 and 23 patients, respectively. Patients who adhered to strict gluten restriction (n=15) demonstrated a similar bone remineralization in the spine than those patients with partial compliance (n=10) (mean Z-score increase: +1.0, in both areas). A greater mean annual change in Z-score in the total skeleton was noted in patients who followed strict gluten restriction (0.4±0.1) respect to those with partial compliance (0.3±0.1); however, this difference was not statistically significant. Pre-menopausal women had significantly greater remineralization that post-menopausals (P〉0.05). Remineralization showed an inverse correlation with the degree of basal osteopenia (r=−0.525; P〈0.002). Conclusions: Long-term treatment with gluten-free diet produces a significant improvement in bone density in coeliac patients. Remineralization was more pronounced in patients who better comply with gluten-free diet, in pre-menopausal women and in patients with the lowest baseline bone mineral density.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.112283000.x
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  • 2
    Digitale Medien
    Digitale Medien
    Idiotypic Replica of an Anti-Human Tumour-Associated Antigen Monoclonal Antibody DNA Sequence Comparison between Ab1 and Ab3 (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 34 (1991), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 2G-3 is an anti-anti-idiotypic MoAb (Ab3) obtained upon immunization wiih a monoclonal Ab2 (A3B10), which behaves as the “internal image” of CaMBrl. a saccharidic epitope defined by MoAb MBrl (Abl), CaMBrI is expressed on glycoconjugates of the human mammary carcinoma cell line MCF-7 und on normal and neoplastic mammary gland epithelial cells, Abl and Ab3. although exhibiting, in many respects, superimposable paratopic and idiotopic specificities, show a non-identical fine immunoreactivity, since 2G-3 has a preferential reactivity with the saccharidic epitope mounted on glycoproteins. while MBrl reacts with both glycoproteins and glycolipids, V-region sequence analysis has shown that: (i) the VK genes employed belong to different families(VK 1 and VK 10); (ii) the J K2 segment is shared by the two L chains(thus a high degree of homology is observed between VK CDR3s): (iii) the VH genes employed derive from the same family VHIIBJ55K (but show CDR homology only in CDR2): (iv) different JM region genes are employed. These data together with the comparison of deduced secondary structure parameters give further evidence fur the possible production of similar combining sites using different VH and VL germ-line genes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1991.tb01559.x
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  • 3
    Digitale Medien
    Digitale Medien
    Expression of β2m-Free HLA Class I Heavy Chains in Neuroblastoma Cell Lines (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 37 (1993), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Flow cytometry with the specific monoclonal antibody (MoAb) L31 was used to analyse the expression of HLA class I heavy chains not bound with β2-microglobulin (β2m) by neuroblastoma (NB) cell lines IMR-32 and LA-N-1. The cells, which express barely detectable amounts of β2m-free (L31-positive molecules) and β2m-complexed HLA class I antigens (W6.32- and BBM. I-reactive molecules), expressed MHC class I molecules not bound to light chains upon differentiation with either retinoic acid or serum starvation. The expression was not accompanied by an increase of surface heterodimers. Conversely, recombinant interferon-γ (rIFN-γ) treatment led IMR-32 and LA-N-1 cells to almost exclusively express β2m-complexed HLA class I heavy chains. Surface β2m-free MHC class I molecules displayed a molecular mass of ~45 kDa and did not bind exogenously added β2m. No changes in the synthesis of either HLA class I and β2m mRNAs or of L31 proteins were observed in differentiated NB cells, thus suggesting that the surface exposure of unusual HLA class I antigens is regulated post-translationally. These findings indicate that, in addition to activated lymphocytes, the surface expression of β2m-free class I heavy chains is a feature of other cell types, such as NB cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1993.tb01680.x
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  • 4
    Digitale Medien
    Digitale Medien
    A high throughput assay for inhibitors of HIV-1 protease Screening of microbial metabolites
    Amsterdam : Elsevier
    FEBS Letters 279 (1991), S. 265-269 
    Details
    ISSN: 0014-5793
    Schlagwort(e): Fusion protein ; Human immunodeficiency virus ; Immunological assay ; Microbial alkaline protease inhibitor ; Proteinase
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(91)80164-X
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  • 5
    Digitale Medien
    Digitale Medien
    The prevalence and clinical significance of chromogranin A and secretogranin II immunoreactivity in colorectal adenocarcinomas (1995)
    Springer
    Virchows Archiv 426 (1995), S. 587-592 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Chromogranin A ; Secretogranin II ; Immunocytochemistry ; Prognosis ; Colorectal adenocarcinomas
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Colorectal adenocarcinomas may display features of endocrine differentiation, shown by argyrophil stains and by the expression of endocrine markers such as chromogranin A. We investigated chromogranin A and secretogranin II immunoreactivity in a series of 208 carcinomas of the large bowel to assess the prevalence and clinical significance of endocrine differentiation. Tumours expressing endocrine markers were classified as low expressors (〈 than 1 immunoreactive tumour cell/mm2) and high expressors (〉 than 1 immunoreactive tumour cell/mm2). There were 33 (16%) carcinomas showing both chromogranin A and secretogranin II immunoreactivity: 11 tumours (5%) were high expressors. Endocrine differentiation was not related to the disease stage, tumour location, grade, DNA ploidy and p53 protein accumulation. In the entire series chromogranin A immunoreactivity did not provide prognostic information using univariate and multivariate analysis. A worse overall survival (P=0.048) was demonstrated for the stage III patients with high expressor tumours, but there were only five patients in this group. The results of our investigation suggest that chromogranin A immunoreactivity is not a useful variable in the prognostic assessment of colorectal adenocarcinomas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00192113
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  • 6
    Digitale Medien
    Digitale Medien
    Staphylocidal defect of polymorphonuclear leukocytes in a patient with Leprechaunism (1981)
    Springer
    European journal of pediatrics 137 (1981), S. 89-90 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Leprechaunism ; Neutrophil functions
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A patient with the features of Leprechaunism had a severe and constant defect of bactericidal activity of his phagocytes. We suggest this abnormality might be the basis of the well known recurrence of infections in this syndrome.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00441177
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  • 7
    Digitale Medien
    Digitale Medien
    Studies on propylamine transfer activity in anti-AdoDATO antibodies (1997)
    Springer
    Amino acids 12 (1997), S. 299-308 
    Details
    ISSN: 1438-2199
    Schlagwort(e): Amino acids ; Catalytic antibodies ; Transition state analogs ; Aminopropyl transferase ; Polyamines
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Based on a structural similarity to the transition state of a propylamine transfer reaction involved in polyamine biosynthesis, Sadenosyl-(5′)-1,8-diamino-3-thiooctane (AdoDATO), the most potent inhibitor of spermidine synthases, was used as a hapten for mice immunization. From immunized mice sera, the IgG fractions were purified by means of affinity (protein A/G) chromatography. Sera and purified polyclonal antibodies from several mice were found to exert spermidine synthase-like activity. Moreover, by means means of hybridoma technology, 19 anti-AdoDATO hybridoma clones have been screened for propylamine transfer activity and at least 6 were found to produce catalytic antibodies. These findings indicate the presence in the sera of active spermidine synthase-like catalytic antibodies. The reported results for the first time evidence the feasibility of preparation of N-alkylating antibodies, widening the biotechnological perspectives of antibodies as biocatalysts.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01373010
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  • 8
    Digitale Medien
    Digitale Medien
    Chromosomal location by in situ hybridization of the human Sau3A family of DNA repeats (1987)
    Springer
    Human genetics 〈Berlin〉 75 (1987), S. 326-332 
    Details
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The Sau3A family is a human, clustered, highly repetitive, GC-rich DNA family. In situ hybridization studies with a plasmid carrying a Sau3A monomer as a probe have shown that Sau3A sequences are preferentially concentrated in the heterochromatic regions of human acrocentric chromosomes (D and G groups, both in pericentromeric regions and in cytological satellites) and in pericentromeric heterochromatin of chromosome 1. The same chromosomal locations were observed by using as probes two recombinant phages which carry Sau3A-positive genomic sectors. The two sectors differfor the relative proportions of monomer and multiples of Sau3A repeats, which show different extents of homology to the cloned monomer, and for the presence, in one of the two, of a samll amount of an unrelated repeat (alphoid DNA). The similarity of the results obtained with the three probes suggests that heterogeneous Sau3A repeats share the same chromosomal localizations and that the two analyzed genomic sectors may not contain significant amounts of repetitive DNAs other than the Sau3A family. A comparison between the chromosomal locations of Sau3A and EcoRI families of repeats has confirmed that each family is characterized by specific chromosomal locations and that single heterochromatic regions may contain both.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00284102
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  • 9
    Digitale Medien
    Digitale Medien
    A defect in neutrophil motility in two siblings with recurrent infections and a remarkable family history (1979)
    Springer
    Infection 7 (1979), S. 45-47 
    Details
    ISSN: 1439-0973
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Bei zwei Geschweistern mit wiederholten Infektionen ist ein wahrscheinlich genetischer Schaden der Granulocyten-Chemotaxis gefunden worden. Durch Häufung von Infekten (Mittelohrentzündung, Bronchitis, chronischer Durchfall) sind sieben Geschwister in der väterlichen Familie in jungem Alter gestorben.
    Notizen: Summary Two siblings with recurrent infections were found to have impaired neutrophil motility. The same association of infections (otitis media, bronchitis, chronic diarrhoea) has caused seven fatalities in the paternal side of the family, suggesting genetic implications.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01640559
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  • 10
    Digitale Medien
    Digitale Medien
    Functional defects of neutrophils in visceral larva migrans syndrome (1980)
    Springer
    Infection 8 (1980), S. 171-173 
    Details
    ISSN: 1439-0973
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Schwere Neutrophilenfunktionsstörungen wurden bei einem Patienten gefunden, der am Larva-viszera-migrans-Syndrom litt. Einige der Defekte (metabolische Aktivierung, bakterizide Aktivität) waren vorübergehend und normalisierten sich mit der Remission, während ein chemotaktischer Defekt über die gesamte Beobachtungszeit hin bestehen blieb.
    Notizen: Summary Severe defects of neutrophil function were found in a patient suffering from larva viscera migrans syndrome. Some of the defects (metabolic activation, bactericidal activity) were transient and normalized at remission, whereas a chemotactic defect persisted throughout the observation period.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01639126
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