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  • 1
    Electronic Resource
    Electronic Resource
    Recognition of Altered Autologous Constituents as Foreign by Phagocytic Cells (1967)
    [s.l.] : Nature Publishing Group
    Nature 213 (1967), S. 824-825 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It has been shown that these "specialized" cells (for example, circulating leucocytes and macrophages of the reticulo-endothelial system) engulf particulate antigens (for example, from microbes, protozoa and red blood and other cells) by means of phagocytosis1'2. They will also take up isolated ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/213824a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Disappearance of SpA-IgG Antibody Complex on ‘Armed’ Lymphoid and Macrophages Cells (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 7 (1978), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The disappearance rate of rabbit IgG antibody complexed with protein A from Staphylococcus aureus (SpA) on ‘armed’ mouse and rabbit spleen lymphocytes, and on ‘armed’ mouse peritoneal macrophages, was investigated by rosette and antibody-dependent cellular cytotoxicity (ADCC) assays. The half time of disappearance of complex from the surface of lymphoid cells was found to be 36 min in both assays. Macrophages, ‘armed’ with IgG antibody complexed with SpA, bind the corresponding antigens and subsequently lyse the target cells by extracellular and/or intracellular mechanisms. ‘Armed’ macrophages have both ADCC and phagocytosis ability, although a short half-time of disappearance of complex was observed (8 min).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1978.tb00463.x
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  • 3
    Electronic Resource
    Electronic Resource
    Arming of Lymphoid Cells by IgG Antibodies Treated with Protein A from Staphylococcus aureus (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 5 (1976), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Mouse spleen lymphocytes treated with rabbit IgG anti-sheep erythrocytes (SRBC) complexed with protein A of Stapbylococcus aureus (SpA) form rosettes with SRBC. The attachment of SRBC to lymphocytes was due to the binding of the SpA-IgG antibody complex to the surface of the lymphocytes and was thus considered ‘arming’ of the cells. Normal mouse spleen cells ‘armed’ with SpA-rabbit IgG anti-chicken erythrocytes (CRBC) kill specifically 51Cr-labeled CRBC ‘in vitro’ in the absence of free antibodies. The killing by these ‘armed’ cells is an effect of the cell-bound SpA-IgG antibody complex. Both the SRBC rosette formation and the cell-mediated CRBC killing was dependent on the concentration of the SpA-IgG antibody complexes used for ‘arming’ the cell. A 100-fold increase in rosette formation or in killing of target cells was recorded for lymphocytes treated with SpA-IgG antibody complexes in comparison with cell treated with noncomplexed IgG antibodies. The specific binding of SpA-IgG antibody complexes to the Fc receptors of mouse spleen cells was demonstrated by inhibition studies. More than 60% inhibition of the rosette formation and in the killing of target cells was shown for cell treated With normal rabbit IgG or its Fc fragment before addition of the SpA-IgG antibody complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1976.tb00262.x
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  • 4
    Electronic Resource
    Electronic Resource
    General Method for the Detection of Cells producing Antibodies against Haptens and Proteins (1970)
    [s.l.] : Nature Publishing Group
    Nature 227 (1970), S. 68-69 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Haemolytic plaques produced by cells producing anti-DNP antibodies.Direct plaques (see text) produced by 4 x 106 mouse spleen cells 7 days after immunization. To avoid these problems we devised a general method of binding hapten and protein antigens to erythrocytes by a simple, fast, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/227068a0
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    Paper (German National Licenses)
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