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  • 1
    Electronic Resource
    Electronic Resource
    Dynamic changes in glucose metabolism of living rat brain slices induced by hypoxia and neurotoxic chemical-loading revealed by positron autoradiography (1999)
    Springer
    Journal of neural transmission 106 (1999), S. 1075-1087 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Brain slice, [18F]FDG, hypoxia, glucose metabolism, positron.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Fresh rat brain slices were incubated with 2-deoxy-2-[18F]-fluoro-D-glucose ([18F]FDG) in oxygenated Krebs-Ringer solution at 36°C, and serial two-dimensional time-resolved images of [18F]FDG uptake were obtained from these specimens on imaging plates. The fractional rate constant (= k3*) of [18F]FDG proportional to the cerebral glucose metabolic rate (CMRglc) was evaluated by applying the Gjedde-Patlak graphical method to the image data. With hypoxia loading (oxygen deprivation) or glucose metabolism inhibitors acting on oxidative phosphorylation, the k3* value increased dramatically suggesting enhanced glycolysis. After relieving hypoxia ≤10-min, the k3* value returned to the pre-loading level. In contrast, with ≥20-min hypoxia only partial or no recovery was observed, indicating that irreversible neuronal damage had been induced. However, after loading with tetrodotoxin (TTX), the k3* value also decreased but returned to the pre-loading level even after 70-min TTX-loading, reflecting a transient inhibition of neuronal activity. This technique provides a new means of quantifying dynamic changes in the regional CMRglc in living brain slices in response to various interventions such as hypoxia and neurotoxic chemical-loading as well as determining the viability and prognosis of brain tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050224
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Incidental aneurysm of the superior cerebellar and non-visualized posterior inferior cerebellar artery: a diagnostic trap (1989)
    Springer
    Neuroradiology 31 (1989), S. 364-365 
    Details
    ISSN: 1432-1920
    Keywords: Aneurysm ; Posterior fossa ; Angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report a case of two aneurysms in the posterior fossa, one of which was first visualized on follow-up arteriography. The mechanism of non-vasualization and re-appearance of the aneurysm is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00344188
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    High signal intensity of both putamina in patients with HIV infection (1991)
    Springer
    Neuroradiology 33 (1991), S. 362-363 
    Details
    ISSN: 1432-1920
    Keywords: Human immunodeficiency virus (HIV) ; Encephalitis ; Magnetic resonance imaging ; AIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report two patients with HIV infection whose MR imaging showed abnormal high signal intensity confined to both putamina on T2-weighted spin echo (SE) images. We assume that they may represent the early manifestations of HIV encephalitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587827
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Spinal epidural abscess with gadolinium-enhanced MRI: serial follow-up studies and clinical correlations (1994)
    Springer
    Neuroradiology 36 (1994), S. 44-48 
    Details
    ISSN: 1432-1920
    Keywords: Spinal infection ; Abscess ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We reviewed serial MRI with and without gadolinium-DTPA in eight patients with spinal epidural abscess and correlated the findings and the clinical manifestations. In four patients, diffuse abscesses spanned four vertebral bodies or more; the others had focal abscesses associated with osteomyelitis and/or diskitis. In three of the four patients with diffuse abscesses, MRI (NCMRI) showed diffuse encasement of the subarachnoid space. Contrast-enhanced MRI (CEMRI) demonstrated linear enhancement surrounding unenhanced pus. In the four patients with focal abscesses, CEMR delineated the inflammatory process more clearly than NCMR. On follow-up studies, decrease in abscess size and better visualization of the subarachnoid space correlated with clinical improvement in both diffuse and focal abscesses. Despite clinical improvement, contrast enhancement persisted in the disk or epidural space of three patients, and was thought to represent chronic granulomatous change or postsurgical scar. CEMR is very valvable for the initial diagnosis of an epidural abscess, particularly if it involves lengthy segments. During follow-up, CEMR can document responses to therapy, and provide information for determining appropriate treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00599195
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    Paper (German National Licenses)
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