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  • 1
    Electronic Resource
    Electronic Resource
    Detection of malignancy in endometrium by brush sampling in 1042 symptomatic patients (1995)
    Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachusetts 02142, USA : Blackwell Science Inc.
    International journal of gynecological cancer 5 (1995), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Endometrial brush samples were taken from 1042 symptomatic hospital patients using Uterobrush®, and the results were compared either to the histology of the endometrium obtained with dilatation and curettage (n = 313) or the patients’ follow-up (n = 729). Only one cancer (100%) among patients 〈inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:1048891X:IJG05030222:les" location="les.gif"/〉 51 years of age (n = 677) was found by this method. Of the 12 cancers among patients〉 51 years of age (n = 365), 11 (91.7%) were detected by Papanicolaou classes III–V. One cancer was missed, whereas no false positive results were found. The diagnostic accuracy in this group of patients varied from 92.3% to 97.8%, depending on the group (true positive vs true negative) to which the Papanicolaou class III was placed. We conclude that endometrial cytology obtained by brushing is useful for symptomatic patients of all age groups and gives an indication for further examination. If cytology is normal and bleeding continues in postmenopausal patients, curettage is indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1995.05030222.x
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  • 2
    Electronic Resource
    Electronic Resource
    Fungal spores in horse stables
    Amsterdam : Elsevier
    Micron And Microscopica Acta 21 (1990), S. 152 
    Details
    ISSN: 0739-6260
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0739-6260(90)90028-E
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  • 3
    Electronic Resource
    Electronic Resource
    Gas-chromatographic determination of the product distribution in the synthesis of sodium borohydride
    Amsterdam : Elsevier
    Talanta 30 (1983), S. 767-770 
    Details
    ISSN: 0039-9140
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0039-9140(83)80175-1
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  • 4
    Electronic Resource
    Electronic Resource
    Long-term results from a phase II study of single agent paclitaxel (Taxol®) in previously platinum treated patients with advanced ovarian cancer: The Nordic experience (1998)
    Springer
    Annals of oncology 9 (1998), S. 1301-1307 
    Details
    ISSN: 1569-8041
    Keywords: advanced recurrent ovarian cancer ; paclitaxel ; second-line treament
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Owing to the wide spread perception of a possible benefit from paclitaxel in the second-line situation the Nordic Gynecologic Oncology Group (NGOG) conducted two prospective phase II studies of paclitaxel single agent treatment (175 mg/m2, three-hour i.v. infusion with standard pre-medication every third week) in patients with relapsing or progressing epithelial ovarian cancer following platinum. Patients and methods: Between 1992–1994 138 patients in total were enrolled of whom 136 received paclitaxel and were included in the toxicity and survival analysis, while 112 were evaluable for response. Results: The overall response rate (CR + PR) was 28% with 16 patients achieving a CR (14%). The estimated median (range) time to progression was 4.1 (0.7–60.7) months. The projected four-year overall survival was 7%, with a median (range) of 9.6 (0.3–60.7) months. A multivariate logistic regression analysis showed that platinum resistance, and WHO performance status at baseline, independently correlated with survival at all three time points (median survival time 9.6, 18, and 24 months). Patients with platinum sensitive tumors and WHO performance status 0 had a median survival of 25.6 months compared to 7.0 months for the rest of the patients (P ≤ 0.0001). No serious toxicity was registered. Conclusion: Paclitaxel could safely be administered in an outpatient setting using this schedule. Patients with platinum sensitive tumors and a good performance status were most likely to survive. However, these patients are also most likely to respond to re-treatment with a platinum compound. With reference to the reasonably good tumor control and limited toxicity observed in this study, we conclude that paclitaxel single agent therapy is a viable option in the salvage situation, which in some patients can give long-lasting responses. However, although responses can be induced in a significant number of patients, the survival figures remain poor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008400324892
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  • 5
    Electronic Resource
    Electronic Resource
    Early signs of critical illness polyneuropathy in ICU patients with systemic inflammatory response syndrome or sepsis (2000)
    Springer
    Intensive care medicine 26 (2000), S. 1360-1363 
    Details
    ISSN: 1432-1238
    Keywords: Critical illness polyneuropathy Systemic inflammatory response syndrome Sepsis Multiple organ dysfunction syndrome Intensive care Neuromuscular blocking agent Electromyography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: To evaluate with electromyography the incidence and the time of appearance of neuromuscular abnormality in patients with systemic inflammatory response syndrome (SIRS) and/or sepsis. Design: Follow-up study. Setting: Intensive care unit of Helsinki University Hospital, Finland. Patients: Nine mechanically ventilated patients with SIRS and/or sepsis. Interventions: Electromyography and conduction velocity measurements on the 2nd–5th day after admission to the intensive care unit. Measurements and results: In all nine patients electromyography revealed signs of neuromuscular abnormality. The means of compound muscle action potential amplitudes of the median and ulnar nerves were decreased. Fibrillation was observed in four patients out of nine. Conclusion: Because neuromuscular abnormalities seem to develop earlier than previously reported, electroneuromyography should be used more frequently as a diagnostic test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340000586
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  • 6
    Electronic Resource
    Electronic Resource
    Nocturnal oxygen saturation and sleep quality in patients with advanced chronic obstructive pulmonary disease during treatment with moderate dose CR-theophylline (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 125-129 
    Details
    ISSN: 1432-1041
    Keywords: Theophylline, Nocturnal hypoxaemia ; chronic obstructive pulmonary disease ; sleep study ; static charge sensitive bed ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of a 24-h controlled-release (CR) preparation of theophylline (Th) on nocturnal arterial oxygen saturation (SaO2) and sleep quality has been evaluated in 7 patients with advanced chronic obstructive pulmonary disease (COPD) in a double-blind cross-over experiment; median values: age 61 y; PaO2 8.0 kPa; PaCO2 5.8 kPa. During treatment with 450–900 mg Th in the evening, morning plasma drug levels ranged from 5.2–12.9 µg·ml−1. During Th and placebo treatment, the median evening FEV1 was 0.45 l and 0.46 l, respectively, and the morning FEV1 was 0.53 l and 0.41 l. Sleep was monitored by whole-night polysomnographic recording of oximetric SaO2, airflow, respiratory and body movements (static charge sensitive bed), eye movements and submental electromyogram. There was no significant difference between Th and placebo in sleep quality. Th treatment was associated with a marginal improvement in nocturnal oxygenation in most of the patients; the average nocturnal SaO2 ranged from 84.4%–92.8% during Th and from 82.2–90.5% during placebo treatment, respectively. Only in the morning, during the last 2 h in bed, was the slight difference in SaO2 statistically significant in favour of Th. It is concluded that a moderate dose of CR-theophylline did not alter the sleep quality or substantially improve nocturnal oxygenation in patients with advanced COPD and mild to moderate day-time hypoxaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01740657
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  • 7
    Electronic Resource
    Electronic Resource
    Growth impairment and growth hormone therapy in children treated for malignant brain tumours (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 764-769 
    Details
    ISSN: 1432-1076
    Keywords: Key words Brain tumours ; Radiotherapy ; Late effects ; Growth hormone therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighty-two children with malignant brain tumours were treated according to the “8 in 1” chemotherapy protocol in Finland during 1986 to 1993. Thirty-seven with brain tumours not involving the hypothalamic-pituitary region are still alive and tumour-free. The growth and response to growth hormone (GH) therapy in these children was analysed. Children who received craniospinal irradiation had the most severe loss of height SDS, being −1.07 within 3 years of the diagnosis. Even children with no irradiation to the hypothalamic-pituitary axis had a mean change in height SDS of −0.5 after 3 years. Fifteen of 23 children who received craniospinal irradiation and two out of eight children who received cranial irradiation have received GH therapy. A catch-up growth response to the daily GH therapy with the mean dose of 0.7 IU/kg per week was complete in 3 years (+1.87 SDS), irrespective of craniospinal irradiation, in children who were treated at prepubertal age but was seen in none of the children who had reached pubertal age. Conclusion Growth impairment and GH deficiency are common in children treated for malignant brain tumours. The response to GH therapy is good in prepubertal children in terms of increased growth velocity, although the final height is not yet known.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050708
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  • 8
    Electronic Resource
    Electronic Resource
    Nocturnal oxygen saturation and body movement in asthmatics treated with controlled-release preparations of theophylline or terbutaline (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 117-121 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; terbutaline ; nocturnal asthma ; sleep recording ; body movement ; oxygen saturation ; sleep quality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Nine adult asthmatics with a history of nocturnal symptoms and with morning dips in peak expiratory flow (PEF) were treated for 10–14 days with 24-h controlled-release preparation of theophylline (Th), or a controlled-release preparation of terbutaline (Te), in a double-blind cross-over experiment. During treatment with 450–900 mg Th in the evening morning, plasma drug levels ranged from 53–95 (mean 73) μmol/l. The Te dose was 7.5 mg twice daily. Morning PEF values during Th (mean 338 l·min−1) and Te (316 l·min−1) were not significantly different. There were no significant differences between the treatments in average nocturnal oximetric O2 saturation (91.9% during Th and 91.0% during Te), or the amount of nocturnal body movement, recorded with a static charge sensitive bed (total number of movements 146 during Th and 120 during Te). No difference between the treatments was seen with respect to assessment by the subjects of sleep quality, which was considered fair or good. The findings suggest that in moderately severe asthma, nocturnal oxygenation and sleep quality were similar during the two treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280043
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  • 9
    Electronic Resource
    Electronic Resource
    The effects of pretransplant conditioning, graft-versus-host disease and sepsis on the CRP levels in bone marrow transplantation (1997)
    Springer
    Infection 25 (1997), S. 335-338 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate the diagnostic utility of C-reactive protein (CRP) for the detection of sepsis in bone marrow transplantation, CRP levels were analyzed after pretransplant conditioning and variably combined in septic, focal or viral infections with graft-versus-host disease (GvHD) in 64 bone marrow recipients. The CRP levels after pretransplant conditioning were low. The peak levels of CRP were influenced independently by the type of infection (p=0.016; septic and viral infections were significantly different) and GvHD (p=0.003). The area under the receiver-operator characteristic (ROC) curve for peak CRP in sepsis was 0.653 and 0.618 with and without GvHD, respectively. It was concluded that GvHD and the type of infection were independent determinants of the CRP responses. GvHD did not affect the extent of the CRP response. Therefore, although not highly specific for sepsis, CRP remains a useful detector of sepsis in bone marrow transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01740812
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  • 10
    Electronic Resource
    Electronic Resource
    Computer assisted detection of REM and non-REM sleep for analysis of nocturnal hypoxaemia in patients with ventilatory impairment (1994)
    Springer
    Journal of clinical monitoring and computing 11 (1994), S. 63-70 
    Details
    ISSN: 1573-2614
    Keywords: chronic obstructive pulmonary disease ; nocturnal hypoxaemia ; sleep stages ; sleep study ; computer analysis ; thoracoplasty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Medicine
    Notes: Abstract A computer-assisted method for the evaluation of sleep and breathing in patients showing chronic ventilatory impairment is described and validated. Signals of body and respiratory movements (static charge sensitive bed), air-flow (thermistors), oxygen saturation (SaO2), electro-oculography (EOG), and electromyography (EMG) were recorded overnight and analysed. Using the compressed output graphs of the data and a rapid scoring procedure, stages of wakefulness, non-REM (stages S1–S4) and REM sleep were identified. The procedure allowed analysis of oxygen saturation data separately for each sleep stage. For validation of the method, the sleep stages identified were compared with traditional sleep staging based on a simultaneous recording of EEG, EMG and EOG in 10 patients with chronic obstructive pulmonary disease (COPD) and in 15 patients treated by thoracoplasty (TPL) for pulmonary tuberculosis. The recordings were performed in a patient ward. In total, 32 night recordings were analysed. In the COPD patients, the sensitivity and specificity of the new method were 87% and 84% in detecting non-REM sleep, and 72% and 87% in detecting REM sleep, respectively. In the TPL patients the sensitivity and specificity were 93% and 89% with respect to non-REM sleep, and 92% and 94% in regard to REM sleep. The new method and traditional sleep staging provided closely similar quantitative estimates of the degree of sleep stage-(REM and non-REM) dependent arterial oxygen desaturation. It is concluded that the computer-assisted method, which is considerably less time consuming than traditional polysomnography, is reliable in studying sleep-related oxygenation in patients with chronic lung diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01132846
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