ISSN:
1432-2072
Keywords:
Antihistaminics
;
Amphetamine
;
Morphine
;
Scopolamine
;
Locomotor activity
;
Mice
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Three histamine H1-receptor antagonists, chlorpheniramine, diphenhydramine and tripelennamine, were tested alone or in combination with morphine, amphetamine and scopolamine on locomotor activity in mice. All three antihistaminics, at some dosage levels, enhanced morphine-induced hyperactivity, but did not change or even reduce locomotor stimulation induced by amphetamine and scopolamine. The results suggest that H1-blocking agents may specifically interact, though not necessarily directly, with opiate mechanisms in producing behavioural effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00179926
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