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  • 1
    Electronic Resource
    Electronic Resource
    Direct evidence of collagenolysis in chronic periodontitis (2003)
    Oxford, UK : Munksgaard International Publishers
    Journal of periodontal research 38 (2003), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  There is no previous evidence that collagenases in chronic periodontitis excessively cleave collagen fibrils.Objectives:  In this study the eventual presence of neoepitopes produced in such a cleavage were looked for.Methods:  A polyclonal antibody, which recognizes collagenase-cleaved collagen type I 3/4 carboxy-terminal neoepitope (COL1-3/4C), was used in avidin–biotin–peroxidase complex staining.Results:  In addition, moderate staining was seen in connective tissue bordering to the sulcular and junctional epithelium, surrounding some of the fibroblasts and in some areas infiltrated by inflammatory mononuclear cells. COL1-3/4C staining in chronic periodontitis was more extensive (6.3 ± 1.2%, n = 10) and intense than that observed in controls (1.6 ± 0.7%, n = 10, Unpaired Student's t-test, p 〈 0.01).Conclusions:  It is concluded that collagenases produced by host cells contribute to periodontal tissue destruction and attachment loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0765.2003.00689.x
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  • 2
    Electronic Resource
    Electronic Resource
    Morphological and biochemical changes in striated muscle after experimental tourniquet ischaemia (1979)
    Springer
    Research in experimental medicine 174 (1979), S. 245-251 
    Details
    ISSN: 1433-8580
    Keywords: Pneumatic tourniquet ; Ischaemia ; Striated muscle ; Lactic dehydrogenase ; Succinic dehydrogenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histological and biochemical changes were studied in the striated muscle following total tourniquet ischaemia between one and four h, the reflow time being 30 min and 24 h. Electronmicroscopy was applied to study the fine structure of the muscle after 24 h reflow. In light microscopy ischaemic changes were not seen even when the tourniquet time was extended to four h. When a four-h ischaemia was followed by a 24-h recovery period, the electron microscopy showed a variety of minor mitochondrial changes such as condensed and slightly dilatated mitochondria. The SDH activities did not vary significantly between the experimental and control samples even after a four-h ischaemia followed by 30 min or 24 h reflow. The differences between the experimental and control samples were, however, highly significant in the LDH values in the groups where ischaemia had lasted for three and four h. The results indicate that tourniquet ischaemia for two to three h does not significantly affect the striated muscle of a rabbit and the alterations even after a four-h ischaemia seem to be partly reversible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851416
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Increased interleukin-8 (IL-8) expression is related to aseptic loosening of total hip replacement (2000)
    Springer
    Archives of orthopaedic and trauma surgery 120 (2000), S. 328-332 
    Details
    ISSN: 1434-3916
    Keywords: Key words Interleukin-8 ; Aseptic loosening ; Total hip replacement ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aseptic loosening is an increasing problem in total hip replacement (THR). Chronic inflammatory reaction against implant wear particle results in collageno- and osteolysis, leading to loosening of the implant. Cytokines are known to play a major role in this particular inflammatory process [10]. The aim of the present study was to examine interleukin-8 (IL-8) in the synovial-like interface membrane (SLIM) and pseudocapsular tissue of THRs and to compare it to normal knee synovial membrane. Eleven patients suffering from aseptically loosened THRs were included. All the SLIM and pseudocapsular tissue samples were obtained during revision operations. Ten control samples of normal synovium were collected per arthroscopy from the superior recessus of the knee. For immunohistochemical IL-8 detection, polyclonal mouse anti-human immunoglobulin (Ig)G1 IL-8-primary antibody was used with the alkaline phosphatase anti-alkaline phosphatase (APAAP) method. Results were quantitated using the Vidas image analysis system. The highest count levels (mean ± SEM) were detected in SLIM tissue (386 ± 82 cells/mm2). The difference was statistically significant compared with pseudocapsular tissue (193 ± 36 cells/mm2) and control samples (18 ± 5 cells/mm2). Count levels in control tissue were on average 5% of the SLIM tissues values. The present study determines for the first time the cellular origin of IL-8 in aseptically loosened THRs and also quantitates the IL-8-producing cells in the periprosthetic tissue. The results reveal a high rise in IL-8 concentration in SLIM and in synovial tissues. This finding moves us one step forward in solving the complex network of multiple factors affecting loosening of hip implants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004020050475
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of atropine on canine bile flow and biliary excretion of ioglycamate (1980)
    Springer
    Research in experimental medicine 178 (1980), S. 37-41 
    Details
    ISSN: 1433-8580
    Keywords: Atropine ; Bile ; Cholangiography ; Contrast media ; Ioglycamic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of atropine on the bile flow and biliary excretion of ioglycamate, a biliary contrast medium, was studied on four anesthetized mongrel dogs equipped with a Thomas cannula through which the common bile duct was cannulated. With an infusion rate of 2 µg/kg/min atropine sulphate decreased bile flow significantly. At the same time, the biliary concentration of ioglycamate was significantly increased. The biliary output of ioglycamate did not change during atropine infusion. The present study suggests that in this experimental model atropine decreases the bile flow but does not affect the excretion of ioglycamate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01856756
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    Paper (German National Licenses)
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