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  • 1
    Electronic Resource
    Electronic Resource
    Simulated public speaking as a model of clinical anxiety (1982)
    Springer
    Psychopharmacology 77 (1982), S. 7-10 
    Details
    ISSN: 1432-2072
    Keywords: Diazepam ; Normal subjects ; Models of anxiety ; Mood ; Palmar sweating ; Public speaking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Normal male volunteers took single acute doses of either diazepam or placebo under double-blind conditions in three simulated public speaking experiments. Measures of palmar sweating and subjective anxiety showed that anticipation of speaking in public increased anxiety relative to baseline and prestress conditions, and performance of public speaking further increased anxiety. A dose-related anxiolytic effect of diazepam on subjective anxiety supported the model's clinical relevance. Moreover, the intensity of the subject's public speaking phobia predicted both degree of prestress anxiety relief from 10 mg diazepam and overall anxiety level, regardless of medication, throughout the experimental session. A measure of traditionalism predicted placebo and 5 mg diazepam response during prestress: As in previous clinical trials, high traditionalism scorers reported more relief from placebo, whereas low scorers showed more relief from diazepam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00436092
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Potentiation of morphine analgesia by d-amphetamine (1986)
    Springer
    Psychopharmacology 90 (1986), S. 163-165 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; d-Amphetamine ; Analgesia ; Potentiation ; Pain ; Opiate ; Rat ; Escape threshold
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to escape from aversive electrical brain stimulation delivered to the mesencephalic reticular formation (MRF). The threshold for this escape behavior was determined by a modification of the classic psychophysical method of limits. Escape thresholds were determined after the administration of morphine alone, d-amphetamine alone, and the combination of d-amphetamine and an ineffective dose of morphine. Morphine alone caused a dose-dependent raising of the escape threshold (1.0–16.0 mg/kg IP) while d-amphetamine alone (0.06–2.0 mg/kg IP) had no effect or caused a slight lowering of threshold. For each animal, a dose of morphine that produced no change in escape threshold was then selected to be administered concomitantly with various doses of d-amphetamine. The co-administration of morphine and d-amphetamine resulted in a significant, dose-dependent increase in the escape threshold, which was not seen with d-amphetamine alone and was as great or greater in magnitude than the increase seen with the highest dose of morphine tested. The results of this study clearly demonstrate that opiate analgesia is potentiated by concomitant d-amphetamine administration. The mechanisms involved in this potentiation warrant further investigation for the clinical management of pain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00181233
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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