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  • 1
    Electronic Resource
    Electronic Resource
    Gene therapy for glioblestome multiforme: in vivo tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir (1997)
    Springer
    Journal of molecular medicine 75 (1997), S. 300-304 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050116
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  • 2
    Electronic Resource
    Electronic Resource
    An Easy and Safe Method to Store and Disinfect Explanted Skull Bone (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 525-528 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Bone flap; preservation; disinfection; microbiological testing.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  In our department extensive decompression craniectomies became the treatment of choice for patients with massive cerebral oedema following either trauma or acute cerebral infarction. The remarkable survival rates of this neurosurgical technique created the problem of adequate vault defect reconstruction. To evaluate the biological safety of using stored autologous skull flaps for this purpose, we compared three different disinfection methods. Skull bone fragments stored at -21\,°C for different periods of time were artificially contaminated with clinically relevant strains of Serratia marcescens, Enterococcus faecium and Staphylococcus aureus. As potential methods for disinfection we tested immersion in 3% H2O2, boiling in normal saline for 15 and 30 minutes and a special process of steam disinfection at a temperature of 75°C for 20 minutes. We were able to demonstrate that only steam disinfection completely eliminated the bacterial strains tested. Refrigeration plus steam disinfection of autologous skull bone prior to re-implantation seems to offer reliable safety for its use for defect closure. It is available at reasonable cost in many hospitals and does not require a bone bank.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050335
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  • 3
    Electronic Resource
    Electronic Resource
    In vitro model for the response to irradiation of different types of human intracranial tumours (1987)
    Springer
    Acta neurochirurgica 85 (1987), S. 46-49 
    Details
    ISSN: 0942-0940
    Keywords: Intracranial tumours ; biopsy ; in vitro irradiation ; radiosensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-seven human low and high grade gliomas and five meningiomas were cultured in vitro as tumour tissue and/or tumour cells. Cell survival or growth was taken as a measure of radiation response. Astrocytomas II–III and glioblastomas manifested individual patterns of radiosensitivity, ranging from 10 to 90 Gy. Meningiomas did not react. Our findings are consistent with the differences in radiosensitivity of human gliomas experienced clinically and corroborate the validity of the in vitro model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402370
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  • 4
    Electronic Resource
    Electronic Resource
    Intraoperative Facial Nerve Monitoring (IFNM) Predicts Facial Nerve Outcome after Resection of Vestibular Schwannoma (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 235-243 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Intraoperative facial nerve monitoring; vestibular schwannoma; acoustic neuroma; facial nerve outcome and functional recovery.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intraoperative facial nerve monitoring (IFNM) is a suitable technique for intraoperative facial nerve identification and dissection, especially in large vestibular schwannomas (VS) (acoustic neuroma). To evaluate its feasibility for estimating functional nerve outcome after VS resection 60 patients underwent surgery using IFNM. Out of this group the last 40 patients were included in a prospective study evaluating the prognostic value of various IFNM parameters (proximal and distal absolute EMG amplitude, stimulation threshold, and proximal-to-distal amplitude ratio) for prediction of initial postoperative facial nerve function and recovery of function. Stimulation threshold and absolute EMG amplitude proximally at the brain stem were both predictive for postoperative nerve function. Good initial facial nerve outcome (modified House Brackmann grading, mHB°I and °II) was found in 15/16 patients with a proximal EMG amplitude greater than 800 μV and in 19/22 patients with proximal stimulation threshold less than 0.3 mA. Sixteen of 16 patients with proximal stimulation threshold equal to or greater than 0.3 mA had moderate-to-severe facial palsy (mHB°III or worse). Six of six patients without evokable proximal amplitude initially had insufficient nerve function (mHB°IV). Intraoperative decrease of the proximal amplitude was associated with an unfavourable outcome, whereas distal amplitudes usually stayed unchanged. Mean distal EMG amplitudes were also found to be decreased with poor nerve function, which may mean that the tumour had already affected the nerve. A proximal amplitude of 300 μV or less and a proximal-to-distal amplitude ratio below 1:3 were found in the absence of functional recovery in 6/8 (75%) and 5/6 (83%) patients with initial mHB°IV, respectively. Two patients with initial mHB°IV improved to mHB°III despite intraoperative evidence of missing functional nerve integrity. Therefore, functional recovery cannot be predicted by IFNM in all cases of anatomical nerve preservation. We conclude that a minimum follow-up period of 1 year may still be advisable even in certain patients without evidence of intraoperative functional nerve integrity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050090
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  • 5
    Electronic Resource
    Electronic Resource
    Multiple Intracerebral Haemangioblastomas in Identical Twins with von Hippel-Lindau Disease – a Clinical and Molecular Study (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 281-285 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Von-Hippel-Lindau disease; VHL tumour suppressor gene; haemangioblastoma; presymptomatic diagnosis; identical twins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: p53 , BRCA1, BRCA2, DCC, and MCC). Furthermore, no mutations were found in the constitutional DNA of either twin sister or in the DNA of all five tumour lesions. Based on our observations, we conclude that in certain VHL families, presymptomatic molecular diagnosis of the disease is not feasible and requires close clinical surveillance of all individuals at risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050096
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  • 6
    Electronic Resource
    Electronic Resource
    Neurochirurgische Therapie der Hirnmetastasen (2000)
    Springer
    Der Onkologe 6 (2000), S. 939-947 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Ziel der neurochirurgischen Therapie von Hirnmetastasen ist die Beseitigung der lebensbedrohlichen Hirndrucksteigerung und die Rückbildung neurologischer Ausfälle. Eine präoperative Behandlung mit Dexamethason ist neben der Reduzierung des perifokalen Ödems ein wichtiges Diagnostikum. Sie dient zur Erkennung, ob die Tumoren funktionell-neurologisch hochwertige Areale unmittelbar betroffen haben, oder ob das Ödem zu neurologischen Ausfällen geführt hat. Hirnmetastasen entstehen meist im Endstadium der generalisierten Metastasierung. Das Gehirn ist jedoch auch, wie im Falle des malignen Melanoms, bevorzugtes primäres Metastasierungsorgan. Aus autoptischen Untersuchungen ist bekannt, daß 70–90% der Melanompatienten zerebrale Absiedlungen aufweisen [14]. Unter konservativer palliativer Therapie haben Patienten mit zerebralen Metastasen eine Lebenserwartung von 1–3 Monaten [32]. Ein wichtiges Ziel der aktiven Behandlung ist neben der Verlängerung der Überlebenszeit die Verbesserung der Lebensqualität. In den letzten Jahren wurden wesentliche Parameter herausgearbeitet, die die Prognose der Patienten bestimmen und das weitere therapeutische Vorgehen festlegen: die Kontrolle des Primärtumors, das Ausmaß der extrazerebralen Metastasierung, das Zeitintervall zwischen Auftreten des Primärtumors und der Hirnmetastase, die Anzahl der zerebralen Metastasen, der Karnofsky-Status, das Alter des Patienten [1, 8, 9, 11, 18, 29].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610070039
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  • 7
    Electronic Resource
    Electronic Resource
    Die Biologie von Hirnmetastasen (2000)
    Springer
    Der Onkologe 6 (2000), S. 976-985 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Eine wesentliche Forderung in der Therapie von Hirnmetastasen ist ein besseres Verständnis der Biologie. Um dies zu erreichen, wurde von uns ein In-vivo-Modell in der Maus etabliert, das wesentliche Schritte des natürlichen Metastasierungsprozesses imitiert, zuverlässig zur Bildung von Hirnmetastasen führt und nur eine geringe Tumorlast in anderen Organen hervorruft [42].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610070043
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  • 8
    Electronic Resource
    Electronic Resource
    Neurochirurgische Therapie der malignen Gliome (1998)
    Springer
    Der Onkologe 4 (1998), S. 599-607 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Die malignen Gliome des Gehirns sind durch ihr infiltratives Wachstum gekennzeichnet. Der Mangel an einer Tumorkapsel und die diffuse Ausbreitung von Tumorzellen in das umgebende Hirngewebe erschweren eine radikale Tumorexstirpation. Im Folgenden werden die neurochirurgischen Therapiemöglichkeiten und ihre Grenzen, ein malignes Gliom durch Operation kurativ zu behandeln, aufgezeigt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610050243
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  • 9
    Electronic Resource
    Electronic Resource
    Human hypersensitivity angiitis: an uncommon cause of death after trauma (1999)
    Springer
    Langenbeck's archives of surgery 384 (1999), S. 200-203 
    Details
    ISSN: 1435-2451
    Keywords: Key words Hypersensitivity vasculitis ; Immune complex disease ; Cerebral haemorrhage ; Myocardial infarction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Introduction: The article demonstrates, using a case report, that death following an accident may have rarely encountered causes that are not a direct result of trauma and that can only be detected by autopsy. Case: An unconscious woman aged 57 years was admitted to hospital. Despite immediate surgery for intracranial haemorrhage diagnosed by means of cranial computed tomography, the patient died showing clinical symptoms of circulatory depression after a brief period of stabilisation. The autopsy established myocardial infarction with hypersensitivity angiitis as the cause of death. Conclusion: In this case, the authors hold the opinion that the intravenous application of antibiotics during the patient's stay in hospital resulted in hypersensitivity angiitis. The factors causing hypersensitivity angiitis, the morphological picture (clinical, histological) and therapeutic measures are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004230050192
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