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  • 1
    Electronic Resource
    Electronic Resource
    Adjuvant high-dose therapy with peripheral blood stem cell support for patients with high-risk breast cancer (1999)
    Springer
    Cancer chemotherapy and pharmacology 44 (1999), S. S13 
    Details
    ISSN: 1432-0843
    Keywords: Key words Breast cancer ; High-dose chemotherapy ; Peripheral blood stem cell transplantation ; Prognostic indicators ; Tumour cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on the efficacy and toxicity of a sequential high-dose therapy with peripheral blood stem cell (PBSC) support in 107 patients with high-risk stage II/III breast cancer. There were 90 patients with more than 9 tumour-positive axillary lymph nodes. An induction therapy of two cycles of ifosfamide (total dose, 7,500 mg/m2) and epirubicin (120 mg/m2) was given, and PBSC were harvested during granulocyte colony-stimulating factor (G-CSF)-supported leukocyte recovery following the second cycle. The PBSC-supported high-dose chemotherapy consisted of two cycles of ifosfamide (total dose 12,000 mg/m2), carboplatin (900 mg/m2) and epirubicin (180 mg/m2). Patients were autografted with a median number of 4.1 × 106 CD34+ cells/kg (range 1.9–26.5 × 106), resulting in haematological reconstitution within approximately 2 weeks following high-dose therapy. The toxicity was moderate in general, and there was no treatment-related toxic death. Twenty-nine patients (27.1% of all patients) relapsed between 3 and 46 months following the last cycle of high-dose therapy (median 15 months). The probability of disease-free and overall survival at 3 years was 56% and 83%, respectively. A multivariate analysis showed that patients with stage II disease had a significantly better probability of disease-free survival (71%) in comparison with patients with stage III disease (30%). The probability of disease-free survival was also significantly better for patients with oestrogen receptor-positive tumours (62%) compared with patients with receptor-negative ones (40%). In conclusion, sequential high-dose chemotherapy with PBSC support can be safely administered to patients with high-risk stage II/III breast cancer. Further intensification of the therapy including the addition of non-cross-resistant drugs or immunological approaches may be envisaged for patients with stage III disease and hormone receptor-negative tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800051110
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  • 2
    Electronic Resource
    Electronic Resource
    Tandem and triple high-dose chemotherapy with autologous stem cell rescue in metastatic breast cancer (1998)
    Springer
    Journal of cancer research and clinical oncology 124 (1998), S. 690-694 
    Details
    ISSN: 1432-1335
    Keywords: Key words Breast cancer ; Chemotherapy ; Transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this phase II study was to evaluate the therapeutic efficacy and toxicity of a tandem or triple high-dose chemotherapy (HDC) with autologous peripheral blood stem cell transplantation (PBSCT) in patients with metastatic breast cancer (MBC) as first line chemotherapy. Conventional chemotherapy consisted of two cycles of epirubicin 120 mg/m2 and ifosfamide 7500 mg/m2 in the case of tandem HDC and one cycle of paclitaxel 135 mg/m2, epirubicin 90 mg/m2 and ifosfamide 6000 mg/m2 in the case of triple HDC. Tandem HDC was composed of two cycles of epirubicin 180 mg/m2, ifosfamide 12000 mg/m2 and carboplatin 900 mg/m2. In the case of triple HDC, paclitaxel 180 mg/m2, etoposide 1500 mg/m2 and thiotepa 600 mg/m2 was added as the third cycle. Patients with tandem HDC (n = 20) were evaluable for both survival and toxicity, and patients with triple HDC (n = 21) only for toxicity because of short-term follow-up. Both tandem and triple HDC were well tolerated and could be safely administered. Non-hematological WHO grade 3 or 4 toxicities were mucositis (8), temporary renal insufficiency (1), myocardial infarction (1), and neuropathy (1). No toxic death occurred. The Kaplan-Meier estimates for 44-months without progression and the overall survival were 12% and 38% respectively. The median survival was 22 months (95% CI: 7.4–51.7 months) and the median progression-free interval 14 months (95% CI: 5.1–43.7 months). In a population with an unfavorable prognosis, tandem HDC showed similar efficacy as to that described in other phase II studies. Triple HDC seems not to improve patient outcome compared to tandem HDC, but a long-term follow up is required.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050233
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  • 3
    Electronic Resource
    Electronic Resource
    Right aortic arch with left descending aorta (circumflex aorta) Roentgenographic diagnosis (1978)
    Springer
    Pediatric radiology 6 (1978), S. 208-210 
    Details
    ISSN: 1432-1998
    Keywords: Right aortic arch ; Circumflex aorta ; Oesophageal indentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Right aortic arch with retroesophageal segment is a rare anomaly with distinctive roentgenographic features. We present 2 patients, who on the barium oesophogram had an additional finding which has not previously been described. The typical features include an indentation on the right upper barium filled oesophagus (in the antero-posterior view), an oblique indentation descending from right to left (caused by the retroesophageal segment) and the left descending aorta. The oblique indentation has not previously been described. The embryology and incidence of the lesion are briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00975538
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  • 4
    Electronic Resource
    Electronic Resource
    Criss-cross heart—a case with horizontal septum, complete transposition, pulmonary atresia and ventricular septal defect (1982)
    Springer
    Pediatric cardiology 3 (1982), S. 325-328 
    Details
    ISSN: 1432-1971
    Keywords: Criss-cross heart ; Horizontal septum ; L-positioned aorta ; Complete transposition ; Pulmonary atresia ; Ventricular septal defect ; Congenital heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Criss-cross heart is a recently described anomaly in which the systemic and pulmonary blood streams cross at the atrioventricular (AV) level, without mixing. A case of criss-cross heart is described in which the right atrium, in a solitus position, communicated with a left-superior positioned, morphologically right ventricle, and the left atrium communicated with a normally located, morphologically left ventricle. The interventricular septum occupied a horizontal plane. Associated defects were complete d-transposition of the great arteries with l-positioned aorta, pulmonary atresia, venticular septal defect, atrial septal defect, and patent ductus arteriosus. To the best of our knowledge this is the first angiocardiographic demonstration of this rare combination of lesions. The literature on criss-cross heart and horizontal septum is reviewed. It is stressed that regardless of whether the criss-cross phenomenon is an anatomical fact or an angiocardiographic illusion, it is an established angiocardiographic entity and should be recognized as such.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02427035
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Unifying link between Noonan's and Leopard syndromes? (1983)
    Springer
    Pediatric cardiology 4 (1983), S. 168-169 
    Details
    ISSN: 1432-1971
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02076346
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    Paper (German National Licenses)
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