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  • 1
    Electronic Resource
    Electronic Resource
    Topical 5-Fluorouracil Treatment of Superficial Basal Cell Epithelioma. A Light and Electron Microscopic Study (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 2 (1975), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 27-year-old patient developed superficial basal cell epitheliomas approximately 20 years after taking Fowler's solution. One of the lesions was successfully treated with topical 2% 5-fluorouracil solution under occlusion. Sequential biopsies of the lesion before, during and after therapy were examined by light and electron microscopy, and the changes at various stages are described. Changes occurred only in tumor cells and adjacent epidermis, and only after occlusion of 5-FU. After one week of occlusive therapy, focal discontinuities in the basal lamina and intercellular spaces were wider with reduction and condensation of tonofilaments. Mitochondrial degeneration was seen along with irregularities in nucleoli. These changes were most prominent after two weeks of occlusive therapy, and many degenerating keratinocytes were seen detached from other cells. One month after cessation of therapy, the entire area was excised, and no evidence of tumor was seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1975.tb00180.x
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  • 2
    Electronic Resource
    Electronic Resource
    Triads in Foetal Skeletal Muscle (1967)
    [s.l.] : Nature Publishing Group
    Nature 216 (1967), S. 985-988 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the gastrocnemius muscle of the rat foetus longitudinally oriented triads were often seen near A–I junctions. This suggests that there is a change from longitudinal to transverse orientation during the development of skeletal ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/216985a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Connections between the T system and sarcoplasmic reticulumWe thank Mr. C. D. Foreman for technical assistance.This work was aided by NSF grant GB-2009 and NIH grant NB 05444-01. (1966)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 155 (1966), S. 1-10 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Electron micrographs of rat gastrocnemius muscle fibers show membrane-like dense structures traversing the space between the transverse system (T) and the terminal segments of sarcoplasmic reticulum (R). The periodicity of the structures, viewed in longitudinal sections of triads, varies from 150-250 Å. The distance between apposed membranes of T and R is 80-100 Å at the level of the dense structures between T and R. The distance is slightly greater than 100 Å at the level of less dense areas which alternate with the dense structures. The scalloped appearance of the R membrane, associated with differences in distance between T and R when the levels of dense structures and less dense areas are compared, leads to the suggestion that a holding force might be exerted by the dense structures. Such a holding force would support the view that the membrane-like dense structures are indeed connections between T and R. If membrane-like connections between T and R completely surround the less dense areas it is possible that a “physiological tight junction” conductive to electrotonic spread of current might exist between apposed membranes of T and R.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091550102
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  • 4
    Electronic Resource
    Electronic Resource
    I segment lengths and thin filament periods in skeletal muscle fibers of the rhesus monkey and the human (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 178 (1974), S. 63-81 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The I segment length has been measured and the number of thin filament periods per I segment has been counted in electron micrographs of Rhesus monkey and human leg muscle fibers. The number of I segment periods in the monkey fiber (60) and in the human fiber (66) multiplied by axial periodicity (385 Å) in thin filaments of living fibers (Huxley and BROWN, '67) plus 1,000 Å allowed for Z line width in living fibers, provided a formula for calculation of I segment lengths in living fibers. The calculated I segment lengths are 2.41 μ for the monkey and 2.64 μ for the human fiber. The ratio of calculated I segment length over an assumed constant thick filament length (1.6 μ) among vertebrates is in close agreement with the ratio of measured I segment length over measured thick filament length in micrographs of frog, rat, monkey and human leg muscle fibers. The calculated I segment length in the frog (1.95 μ) is compared with that of the human (2.64 μ) to show the relation of I segment length to the length-developed tension diagram and to the series elastic components of the skeletal muscle fiber.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091780107
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  • 5
    Electronic Resource
    Electronic Resource
    Relationship of the sarcoplasmic reticulum to fibril and triadic junction development in skeletal muscle fibers of fetal monkeys and humans (1975)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 146 (1975), S. 97-127 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Examinations of stages of fibril development in muscle fibers of seven Rhesus monkey and six human fetuses reveal SR tubules encircling the Z lines at all stages of fibril development. The encircling SR tubules are continuous with the SR network of tubules which is found surrounding fibrils at all stages of development observed. The SR tubules encircling the Z lines show connections (electron-opaque strands) with the Z lines. The developing triadic junction shows a progressive increase in complexity of structures within the junction. First, membranes of T and SR become apposed with no visible structure between them. Second, tenuous connections are found traversing the space between apposed membranes. Third, well developed bridges are seen traversing the space. And finally, an intermediate density midway between the apposed membranes and parallel to them is found in favorable sections. Junctions between T tubule membranes were also observed and the structures in these junctions are somewhat similar to those found in junctions between T and SR membranes. The change in orientation of triads from predominantly longitudinal to predominantly transverse is complete in the 18-week monkey fetus and incomplete in the latest stage (28-week) of fetal development observed in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051460106
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    Paper (German National Licenses)
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