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  • 1
    ISSN: 1432-055X
    Keywords: Schlüsselwörter EEG ; Anästhesie ; Monitoring ; Ableitungsauswahl ; automatische Narkosetiefebestimmung ; Key words EEG ; Anaesthesia ; Monitoring ; Selection of channels ; Automatic staging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The conventional multichannel electroencephalogram is quite inconvenient for long-term monitoring in the operating theatre or intensive care unit. Recording of the EEG would be easier if a small number of channels was sufficient. Aiming at reduction of channels, leads from different regions of the scalp were analysed visually and with regard to their spectral content. Methods. Electrode placements corresponded to the International 10/20 System (Fig. 1). EEG recordings were made with a conventional device (ES 12000), a personal computer, and a spectral analyser. Two-channel recordings. Retrospective analysis was performed on data from 392 patients (age 14–90 years) whose anaesthesia was induced with various anaesthetics/narcotics, for instance thiopental, ketamine, etomidate, halothane, and enflurane. The EEG was recorded using C3–P3 and Cz–A1. For each patient the changes of spectral parameters during the course of the induction were plotted and visually analysed. For statistical analyses a 30-s epoch of each patient was randomly selected from the first few minutes after the beginning of induction. Ten-channel recordings. In ten gynaecological patients (age 26–55 years) EEG recordings were performed during induction of anaesthesia with thiopental in combination with fentanyl, N2O and O2. The set of channels consisted of Fz′–Cb1, F3′–Cb1, Cz–Cb1, C3–Cb1, P3–Cb1, Oz–Cb1, Fz′–F3′, F3′–C3, C3–P3, and P3–Oz. The electrodes Fz′ and F3′ were positioned on the forehead near to Fz and F3, respectively. These sites were chosen because they allow easy application of electrodes. The relationship between channels was calculated with Bravais-Pearson's coefficient of correlation for the power and the absolute power in the frequency bands delta (0.5–3.5 Hz), theta (3.5–7.5 Hz), alpha (7.5–12.5 Hz), and beta (〉12.5 Hz). Results. In visual and statistical analyses of the two- and ten-channel recordings under the influence of anaesthetics/narcotics, similar changes of EEG activity could be observed in all channels. Although differences in the absolute power of the frequency bands were present, there was high conformity in the composition of the spectral content of the different channels. Classification of the EEG into stages of anaesthesia by means of a single channel led to consistent results for all channels. Alpha activity as leading feature of the awake state predominated occipitally. In channels including the region around the ears, contamination with EKG artifacts was observed. Conclusions. EEG patterns under the influence of different anaesthetics/narcotics are adequately represented by a reduced number of channels. For the choice of an appropriate set of channels the following aspects should be considered. Contamination with artifacts should be as low as possible, electrode sites should easily be accessible, and special features of the awake state should be identifiable. Experience with routinely conducted EEG recordings in the operating theatre and the intensive care unit showed that the channels C3–P3 or C4–P4 provide a sufficient basis for automatic staging of the depth of anaesthesia, which is implemented in the EEG monitor Narkograph.
    Notes: Zusammenfassung EEG-Registrierungen mit einer größeren Anzahl von Ableitungen sind technisch aufwendig. Als Routinemonitoringverfahren z.B. zur Beurteilung der Effekte von Anästhetika/Narkotika bei der Steuerung der Narkose sind sie daher wenig geeignet. Die EEG-Ableitung wäre einfacher, wenn sie mit wenigen Kanälen erfolgen könnte. Daher sollten in dieser Arbeit EEG-Ableitungen von unterschiedlichen Regionen des Kopfs mit dem Ziel einer Kanalreduktion visuell und im Hinblick auf den spektralen Gehalt verglichen werden. Dazu wurden 392 EEG-Kurven mit zwei Kanälen aus Narkoseeinleitungen mit unterschiedlichen Anästhetika/Narkotika und zehn EEG-Aufzeichnungen mit jeweils zehn Kanälen bei Narkoseeinleitungen mit Fentanyl und Thiopental untersucht. Die visuellen und statistischen Auswertungen zeigen, daß unter dem Einfluß von Anästhetika/Narkotika in unterschiedlichen Ableitungen gleichartige EEG-Bilder auftreten und anhand einer einzelnen dieser Ableitungen eine Stadienklassifikation möglich ist. Bei eigenen Routinemessungen haben sich die Ableitungen C 3 −P 3 oder C 4 −P 4 als Grundlage für ein EEG-Monitoring in der Anästhesie als geeignet erwiesen. Diese Ableitungen bieten neben leichter Zugänglichkeit der Ableiteelektroden gute Voraussetzungen für die Erkennung des Wach-EEG und sind im Vergleich mit anderen Ableitungen artefaktarm.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 44 (1995), S. 467-472 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter EEG ; Alterseffekte ; Anästhesie ; Deltaleistung ; Monitoring ; Key words EEG ; Aging ; Anaesthesia ; Delta power ; Monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The number of older persons who have to undergo surgical procedures is steadily growing. For these patients the risks of anaesthesia are often increased because of their past medical history and their restricted physiological resources. Apart from parameters of the cardiovascular system, the electroencephalogram (EEG) represents a supplementary method for intraoperative monitoring, because cerebral alterations caused by anaesthetics or narcotics are directly reflected in the EEG. In routinely conducted registrations of the EEG in the operating theatre it appeared that the EEG of older persons differed from the EEG of younger patients. The aim of the present study was to further investigate the effect of patients' age on the EEG during anaesthesia. Methods. Three data sets from different EEG registrations were analysed. The first data set consisted of inductions of anaesthesia with 7 mg/kg body weight thiopental in 43 patients from 17 to 80 years of age (mean 53.6±16.7 years) using derivations C3-P3 and Cz-A1. The second data set included 69 EEG registrations of general anaesthesia induced with barbiturates and maintained with enflurane in patients from 16 to 83 years (mean 51.4±17.7 years). The third data set comprised inductions of anaesthesia with 2 mg/kg body weight propofol. EEGs of the second and third data set were recorded with the EEG monitor `Narkograph' using derivation C3-P3 and derivations C3-P3/C4-P4, respectively. Classification of the EEGs was performed according to the proposals of Kugler [12]. The basis for the statistical analysis of all data sets was formed by parameters from the power spectra of the EEG recordings. Results. The data from inductions of anaesthesia with thiopental and propofol showed EEG patterns from alpha-EEG to burst suppression activity, whereby periods with burst suppressions could more often be observed in the EEG of older people. Under thiopental burst suppression activity occured in 20% of patients up to 50 years, in 47% of those between 50 and 70 years and in 89% over 70 years. The corresponding figures for propofol were 0%, 5% and 54%, respectively. Figure 2 depicts the correlation between age and power for the thiopental data. The power decreases with increasing age of the patients. This result led to further investigations of the effect of patients' age on the power in different EEG stages. Of special interest were deep stages of anaesthesia, because especially in these stages visual inspections revealed smaller amplitudes of the EEG signal for older patients than for younger persons. Figure 3 shows the power in the delta frequency band in deep stages of barbiturate-induced enflurane anaesthesia for patients of different age groups. The power in the delta frequency band distinctly decreases for geriatric patients. The same effect could be observed for the propofol data (Fig. 4). Conclusions. The EEG represents an important method for effective intraoperative monitoring and contributes to an individually adjusted couse of anaesthesia, especially for geriatric patients. In these patients, clinical signs such as parameters of the cardiovascular system, which are usually used to judge the depth of anaethesia, are often altered by the patient's past medical history or by drugs. Furthermore, geriatric patients show a reduced need for narcotic agents. However, the variation of the required dosage is greater in older than in younger persons. The results of the present study show that with regard to an automatic classification of the EEG during anaesthesia, alterations of the EEG with age have to be taken into account.
    Notes: Zusammenfassung In routinemäßigen intraoperativen EEG-Registrierungen von älteren Patienten wurden in tiefer Narkose häufig niedrigere Amplituden beobachtet als bei jüngeren Personen. Daher sollte das Narkose-EEG mit Hilfe mehrerer Meßreihen gezielt auf Alterseffekte untersucht werden. Ausgewertet wurden EEG-Registrierungen aus Einleitungsphasen mit 7 mg/kg KG Thiopental bzw. 2 mg/kg KG Propofol sowie aus barbituratinduzierten Enflurannarkosen. Bewertungen des Original-EEG erfolgten in Anlehnung an die Kriterien von Kugler [12]. In den Narkoseeinleitungen mit Thiopental und Propofol traten EEG-Stadien vom Wachzustand bis zu Burst-Suppression-Aktivität auf. In beiden Gruppen erreichten alte Patienten besonders häufig Burst-Suppression-Phasen. In D- und E-Stadien der tiefen Narkose fand sich bei älteren Patienten eine geringere Leistung im Deltaband sowie eine niedrigere Gesamtleistung. Die Ergebnisse zeigen, daß es für den Einsatz einer automatischen EEG-Interpretation erforderlich ist, altersabhängige Veränderungen des Narkose-EEG zu berücksichtigen. Gerade für ältere Patienten, bei denen häufig Vorerkrankungen und eingeschränkte physiologische Leistungsreserven vorhanden sind, ist ein intraoperatives EEG-Monitoring von besonderem Wert, denn das Elektroenzephalogramm erleichtert die Beurteilung der Wirkung zentral wirksamer Medikamente und trägt so zu einer differenzierten Narkoseführung bei.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 54 (1976), S. 335-338 
    ISSN: 1432-1440
    Keywords: Acromegaly ; TRH ; Human growth hormone ; Human prolactin ; Akromegalie ; TRH ; Wachstumshormon ; Prolactin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung TRH kann im Gegensatz zum Gesunden bei Patienten mit aktiver Akromegalie zu einem Anstieg der Wachstumshormon-(hGH)-Spiegel führen, wohingegen die Prolactin-(hPRL)-Sekretion bei aktiver Akromegalie vermindert sein soll. Bei 23 Patienten mit aktiver Akromegalie (hGH: 68,5±19,9 ng/ml; ±SE) und 15 Patienten mit inaktiver Akromegalie (hGH: 2,3±0,4 ng/ml; ±SE) wurde die TRH-induzierte hGH- und hPRL-Sekretion untersucht. Bei 14 der aktiven Akromegalen kam es nach 200 µg TRH i.v. zu einem zum Teil exzessiven Anstieg der hGH-Spiegel auf mindestens das Doppelte des Basalspiegels. Von den Patienten mit inaktiver Akromegalie wurde nur in einem Fall ein solcher TRH-induzierter hGH-Anstieg gefunden. Die basalen hPRL-Spiegel waren bei 9 der Patienten mit aktiver Akromegalie erhöht und lagen bei den übrigen im Bereich der Norm. Mit Ausnahme von 3 Patienten mit normalem hPRL-Spiegel und einer Patientin mit exzessiv erhöhtem Serum-hPRL mit einem hGH-und hPRL-produzierenden Tumor wurde bei allen ein regelrechter Anstieg der hPRL-Sekretion nach TRH beobachtet. Von den inaktiven Akromegalen hatten 9 erniedrigte hPRL-Spiegel und nur 8 einen normalen hPRL-Anstieg nach TRH. Die Patienten mit eingeschränkter hPRL-Sekretion hatten postoperativ auch weitere Zeichen der Hypophysenvorderlappeninsuffizienz. Diese Befunde zeigen im Gegensatz zu früheren Berichten, daß eine normale oder vermehrte hPRL-Sekretion bei aktiver Akromegalie gefunden werden kann. Der paradoxe Anstieg des hGH nach TRH ist mit einem Verlust der Receptorspezifität für GRH der Adenomzelle vereinbar. Ein TRH-induzierter hGH-Anstieg bei inaktiver Akromegalie mit normalen hGH-Basalspiegeln weist auf in der Sella turcica verbliebenes Adenomgewebe hin.
    Notes: Summary Inappropriate stimulation of growth hormone (hGH)-secretion with TRH in acromegalic subjects has been shown previously, whereas prolactin (hPRL) secretion was reported to be blunted in active acromegaly. In this study TRH induced hGH and hPRL secretion was investigated in 23 active (mean hGH level: 68.5±19.9 ng/ml; ±SE) and 15 inactive acromegalics (mean hGH level: 2.3±0.4 ng/ml; ±SE). Fourteen of the active acromegalics showed a significant increase up to more than double of the basal hGH level after 200 µg TRH while in only one of the inactive acromegalics an inappropriate rise of hGH was induced by TRH. Basal hPRL levels were elevated in 9 and within normal range in 14 of the patients with active acromegaly. Except in 3 patients who had normal basal hPRL levels and in one patient with excessively elevated hPRL and hGH levels due to an hPRL and hGH producing adenoma, all patients had normal hPRL responses to TRH. In those with inactive acromegaly, 9 had hPRL levels below normal and only 8 out of the 15 patients showed a normal rise of hPRL after TRH. The patients who showed no hPRL response to TRH demonstrated also other signs of pituitary insufficiency due to the operative procedure. In contrast to a previous report these findings demonstrate that normal or enhanced hPRL secretion is found in active acromegaly. The inappropriate rise of hGH after TRH is compatible with a loss of specificity of the recptor for GRH of the adenoma cell and can be found also in patients with normal basal hGH levels after treatment suggesting that remaining adenoma tissue is present in the pituitary fossa.
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 228 (1982), S. 279-284 
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 7 (1968), S. 120-125 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Scientia Horticulturae 18 (1982), S. 1-8 
    ISSN: 0304-4238
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Chromatography A 269 (1983), S. 208-212 
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Chromatography A 299 (1984), S. 484-486 
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Cochlear implantation is a widely used means of treating deafness and severe hearing disorders. The surgical procedure includes inserting the cochlear implant electrode array into the cochlea and embedding the corresponding signal receiver in the mastoid bone behind the ear. Postoperative fitting of the externally worn speech processor is very important for successful use of the cochlear implant. For this purpose, electrically elicited stapedius reflex threshold values can be used. However, stapedius reflex threshold values measured intraoperatively are influenced by anaesthetics. The goal of this retrospective study was to find out whether electroencephalogram (EEG) control of anaesthesia produces more reliable reflex threshold values as a basis for the fitting of the speech processor.Methods Three groups of children, after surgery for cochlear implantation, were analysed with regard to the magnitude of intraoperative electrically elicited stapedius reflex threshold values and their deviations from postoperatively determined maximum comfortable levels (group 1: methohexital/remifentanil with EEG monitoring, n = 10; group 2: isoflurane/fentanyl with EEG monitoring, n = 9; group 3: isoflurane/fentanyl without EEG monitoring, n = 11).Results Children with EEG monitoring had significantly lower electrically elicited stapedius reflex threshold values and also significantly lower differences between intraoperative stapedius reflex threshold values and postoperatively determined maximum comfortable levels.Conclusions Electroencephalogram monitoring in cochlear implantation is of considerable value in controlling anaesthesia and improving speech processor fitting based on more reliable intraoperative neurophysiological data.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 47 (1991), S. 1700-1702 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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