ISSN:
1420-9071
Keywords:
Mouse brain
;
convulsions
;
forskolin
;
anti-convulsant drugs
;
cAMP, cerebral
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Forskolin, an adenylate cyclase activator when injected s.c. (1 mg/kg) in mice, caused an elevation of cAMP in the forebrain and cerebellum of up to 170% and 130%, respectively. The treatment was found to prevent seizures induced by pentylenetetrazol. This suppression had subsided 30 min after the injection, when cAMP level was again normal in the cerebellum but still elevated in the forebrain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01946669
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