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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 27 (1988), S. 5179-5188 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Knowledge and information systems 2 (2000), S. 161-184 
    ISSN: 0219-3116
    Keywords: Keywords: Biomedical applications; Data engineering; Distance metrics; Knowledge discovery; Visualization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract. In this paper we present an index structure, called MetricMap, that takes a set of objects and a distance metric and then maps those objects to a k-dimensional space in such a way that the distances among objects are approximately preserved. The index structure is a useful tool for clustering and visualization in data-intensive applications, because it replaces expensive distance calculations by sum-of-square calculations. This can make clustering in large databases with expensive distance metrics practical. We compare the index structure with another data mining index structure, FastMap, recently proposed by Faloutsos and Lin, according to two criteria: relative error and clustering accuracy. For relative error, we show that (i) FastMap gives a lower relative error than MetricMap for Euclidean distances, (ii) MetricMap gives a lower relative error than FastMap for non-Euclidean distances (i.e., general distance metrics), and (iii) combining the two reduces the error yet further. A similar result is obtained when comparing the accuracy of clustering. These results hold for different data sizes. The main qualitative conclusion is that these two index structures capture complementary information about distance metrics and therefore can be used together to great benefit. The net effect is that multi-day computations can be done in minutes.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The journal of supercomputing 8 (1994), S. 195-207 
    ISSN: 1573-0484
    Keywords: Genetic algorithms ; RNA structure prediction ; massively parallel ; dynamic programming ; optimization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract We present a new method for predicting RNA secondary structure based on a genetic algorithm. The algorithm is designed to run on a massively parallel SIMD computer. Statistical analysis shows that the program performs well when compared to a dynamic programming algorithm used to solve the same problem. The program has also pointed out a long-standing simplification in the implementation of the original dynamic programming algorithm that sometimes causes it not to find the optimal secondary structure.
    Type of Medium: Electronic Resource
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