Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    The tissue distribution in BALB/c mice of C-14-labeled JM216, an orally active platinum antitumour compound (1996)
    Springer
    Cancer chemotherapy and pharmacology 39 (1996), S. 170-175 
    Details
    ISSN: 1432-0843
    Keywords: Key words JM216 ; Platinum tissue distribution ; BALB/c mice ; Carbon 14
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The ammine/amine platinum(IV) dicarboxylates have been developed as orally active platinum antitumor agents, and one of these, [PtCl2(NH3)(C6H11NH2) (OCOCH3)2] (JM216), is undergoing clinical trials at present. A synthesis method was developed to radiolabel JM216 with carbon 14 at the carboxylate carbon. The labeling efficiency was 92%, and the purity as shown by high-performance liquid chromathography (HPLC) was 96% after recrystallisation. The radiolabeled JM216 was given orally to BALB/c mice and detailed tissue-distribution data were obtained (blood plasma, kidney, liver, spleen, brain, lung, muscle and skin) for time points of 2 h and 2, 6 and 10 days. Comparison of these data with previously reported data for distribution of platinum obtained by atomic absorption spectroscopy has shown distinct differences, especially for the liver and the kidney. This clearly indicates a difference in behaviour between the labeled ligand and the platinum centre, suggesting detachment of the ligand in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050555
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    An evaluation of apomorphine action on dopaminergic receptors (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1441-1443 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The controversial literature reports leave open a question whether apomorphine (APO) and dopamine (DA) share a common receptor? After careful evaluation of the arguments, both for and against, about direct action of APO on DA receptor we propose that rigid molecules like APO holdtrans-cisoid conformation and preferably interact with the pre-synaptic DA receptors while ADTN (2-amino-6,7-dihydroxy, 1,2,3,4-tetrahydronaphthalene) incorporatestrans-transoid conformation and primarily acts on post-synaptic DA receptors. Dopamine, by virtue of its molecular flexibility, can act on both the receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923234
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Specific neuro-radiological diagnosis of Herpes encephalitis in an animal model (1988)
    Springer
    Archives of virology 101 (1988), S. 1-12 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The potential of utilizing a radio-labelled derivative of the antiviral drug (E)-5-(2-iodovinyl)-2′-deoxyuridine (IVDU) for the specific, non-invasive, in vivo diagnosis of Herpes simplex virus encephalitis (HSVE) was investigated in a rat model of the disease. Following pharmacological disruption of the blood brain barrier radiolabelled IVDU was administered by intra-carotid injection. Brain radioactivity was compared between control and infected animals via gamma camera scintigraphy. After clearance of non-metabolized drug, markedly higher levels of activity were found in infected brain. Post-mortem studies of cryostat sections of brain examined by autoradiography and immunochemical staining showed the radioactivity selectively accumulated in areas of virus infection. These results indicate that radio-labelled derivatives of antiviral drugs may allow the specific neuro-radiological diagnosis of HSVE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314647
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Estimates of natural cross pollination in Egyptian clover (1985)
    Springer
    Euphytica 34 (1985), S. 147-151 
    Details
    ISSN: 1573-5060
    Keywords: Trifolium alexandrinum ; Egyptian clover ; natural cross-pollination ; flower colour genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The extent of natural cross-pollination in Egyptian clover cultivated in Punjab, India, varied from zero to 4.73% in all the three different sowing arrangements. The high out-crossing percentage in the alternate plant (1.57%) and the concentric circle arrangement (1.6%) was due to the close proximity of the pollen source and the abundant pollen supply.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00022874
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Inheritance of grain threshability in rice (1982)
    Springer
    Euphytica 31 (1982), S. 815-816 
    Details
    ISSN: 1573-5060
    Keywords: Oryza sativa ; rice ; inheritence ; threshability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Inheritance of grain threshability was studied in a cross between two indica rice varieties. Hard threshability was found to be completely dominant over easy threshability. The segregation pattern indicated threshability to be monogenically controlled.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00039222
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Mode of pollination and seed setting in Egyptian clover (1985)
    Springer
    Euphytica 34 (1985), S. 745-750 
    Details
    ISSN: 1573-5060
    Keywords: Trifolium alexandrinum ; Egyptian clover ; floral biology ; pollination ; seed setting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The average cross-pollination in Egyptian clover under caged and uncaged conditions was 0.51% and 1.44% respectively. The low percentage of cross-pollination under caged conditions was due to the absence of honey bees, calm atmosphere and reduced photosynthesis whereas higher outcrossing under uncaged conditions was both by wind and honey bees activities. Per cent seed set was higher under uncaged conditions (53.0%) compared with that of seeds set under caged conditions (26.3%) and uncaged + hand tripping (52.3%). The honey bees have been found to increase seed set in Egyptian clover by tripping mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00035412
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    HM-PAO-imaging and herpes encephalitis (1989)
    Springer
    Archives of virology 109 (1989), S. 263-268 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Selective uptake of the cerebral blood-flow imaging agent99mTc-hexamethylpropyleneamine oxime (HM-PAO) by Human Herpesvirus 1 (HSV-1) infected cells was investigated in vivo and in vitro. No specific uptake of HM-PAO was observed either in encephalitic rats (by brain scintigraphic imaging or by immunoperoxidase staining/autoradiography of brain sections) or in HSV-1 infected Vero cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01311086
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    The circulatory mechanism and anatomy of the heart of the frog, Rana pipiens (1961)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 109 (1961), S. 323-349 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051090307
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    The anatomy and mode of action of the heart of the frog, Rana tigrina daud (1957)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 100 (1957), S. 313-343 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051000205
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...