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  • 1
    Electronic Resource
    Electronic Resource
    Role of Interleukin-4 in the Negative Regulation of Proliferation of Chronic Myelomonocytic Leukemia Cells (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 628 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb17235.x
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  • 2
    Electronic Resource
    Electronic Resource
    CD7-positive acute myeloid leukemia: further evidence of cellular immaturity (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 386-388 
    Details
    ISSN: 1432-1335
    Keywords: AML ; CD7 ; CD34 ; Flow cytometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Among 63 cases of acute myeloid leukemia (AML), 14 were found to express the CD7 antigen, a cell surface marker usually found at an early stage during T lineage differentiation. The CD7-positive AML cases consisted of 5 cases of M1, 3 cases of M2, 3 cases of M4, 1 case of M5, 1 case of M6 and 1 case of M7. Among these 63 cases, the proportion of blast cells expressing the CD34 antigen was examined. The proportion of CD34-stained cells among the CD7-positive AML cases, although varying, was significantly larger than that among the CD7-negative AML cases (P〈0.05). As the CD34 antigen was expressed on hematopoietic progenitor cells and was considered to reflect an early hematopoietic stage, the high proportion of cells expressing CD34 among the CD7-positive AML cases may support the notion that CD7-positive AML cells are immature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01294444
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  • 3
    Electronic Resource
    Electronic Resource
    A host gene controlling early anaemia or polycythaemia induced by Friend erythroleukaemia virus (1982)
    [s.l.] : Nature Publishing Group
    Nature 296 (1982), S. 577-579 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The polycythaemia strain of FV-P has been used extensively in studies of host genetic control as well as its interaction with the haematopoietic progenitor cells15'16. Most of such studies used mice strains DBA/2 and BALB/c. We have now extended these studies to other mice strains, notably CBA. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/296577a0
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  • 4
    Electronic Resource
    Electronic Resource
    Spontaneous remission from acute exacerbation of chronic adult T-cell leukemia (1990)
    Springer
    Annals of hematology 61 (1990), S. 346-349 
    Details
    ISSN: 1432-0584
    Keywords: Adult T-cell leukemia ; Acute exacerbation ; Spontaneous remission ; Infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Spontaneous remission without any anti-cancer therapy in a 57-year-old woman with adult T-cell leukemia (ATL) is reported. The patient was referred to our department because of persistent cough and appearance of abnormal lymphocytes in the peripheral blood, and she was diagnosed as having chronic ATL. Eight months later, she was re-admitted because of cystitis, watery diarrhea and worsening of respiratory symptoms with an increase of ATL cells (WBC 31 × 109/l with 56% ATL cells). Acute exacerbation of ATL was diagnosed. Interestingly, antibiotic therapy for the pulmonary and urinary tract infections brought about spontaneous reduction of the ATL cell count. Spontaneous remission of ATL continued for one year without chemotherapy. The role of infection as a trigger of acute exacerbation and spontaneous remission of ATL is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01738547
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  • 5
    Electronic Resource
    Electronic Resource
    Simultaneous occurrence of myelomonocytic leukemia and multiple myeloma: Involvement of common leukemic progenitors and their developmental abnormality of “lineage infidelity” (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 148 (1991), S. 446-456 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: We investigated the origin of leukemic progenitors in a case of the simultaneous occurrence of myelomonocytic leukemia and multiple myeloma (IgG-K). At presentation, myeloperoxidase and nonspecific esterase-positive myelomono-cytic cells had proliferated up to 12.2 x 109/liter in the peripheral blood. Bone marrow cell differentials revealed the coexistence of myelomonocytic cells (30%) and atypical plasmacytoid cells (26%). Myelomonocytic cells in peripheral blood expressed both myeloid antigens (CD11b, CD13, CD14, CD15, CD33) and T/B-lymphoid antigens (CD2, CD4, CD5, CD7, CD10, PCA-1). Bone marrow mononuclear cells (BMMC) could be divided into PCA-1 strongly positive and PCA-1 weakly positive populations, which were considered to represent myeloma cells and myelomonocytic cells, respectively; the former were CD2-positive (CD2+), CD14-, and CD15-, whereas the latter were CD2+, CD14+, and CD15+. Immunohistochemical analysis revealed that, in addition to plasmacy-toid cells, a minority of myelomonocytic cells showed a positive reaction for IgG staining, and production of IgG was observed in the culture supernatant of CD14+ myelomonocytic cells in peripheral blood. Southern blot analysis revealed the presence of two identical rearrangement bands of immunoglobulin heavy chain gene in both BMMC containing myeloma cells and myelomonocytic cells and CD14+ myelomonocytic cells in peripheral blood. In a long-term methylcellulose assay, peripheral blood mononuclear cells produced large compact colonies consisting of macrophages and IgG+ plasmacytoid cells (Mφ/P colonies), while BMMC produced a different type of colonies consisting of CD14+ myelomono-blasts, macrophages, and IgG+ plasma cells (Mb/Mφ/P colonies) in addition to Mφ/P colonies. Recloning experiments showed that primary Mb/Mφ/P colonies gave rise to both secondary Mφ/P and Mb/Mφ/P colonies. These observations strongly suggest that common leukemic progenitors provide both myeloma and myelomonocytic leukemia cells, and the mechanism of “lineage infidelity” is probably involved in the development of their “bilineal” differentiation.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041480317
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  • 6
    Electronic Resource
    Electronic Resource
    Characterization of the early and late stages of myelomonocytic leukemia induced by friend helper-independent virus F-MuLV: Isolation and induction of friend myelomonocytic leukemic cell lines (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 117 (1983), S. 283-289 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: With the use of cloned helper-independent Friend leukemia virus (F-MuLV), we have induced a high incidence (∼ 70%) of myelomonocytic leukemia in mice resistant (Fv-6rr or Fv-6rs) to erythroleukemia induction by this virus. The spleen cells from these mice (DBA/2 or BALB/c × DBA/2) were found to contain a high level of progenitor cells capable of forming granulocytic and macrophage colonies (CFU-GM). These CFU-GM, however, were different from those in the speens of uninfected mice, as they were either very sensitive to or independent of conditioned medium. No erythroid progenitor bursts (BFU-E) or precursor (CFU-E) cells were detected in the speens of these diseased animals. If these mice with myelomonocytic leukemia were kept alive by transfusion of red blood cells from uninfected mice, tumorigenic cell lines, capable of being transplanted, into adult mice can be isolated. Three such cell lines TTA-1, TTA-3, and TTA-9 have been established, and they retain their morphology of monocytes and macrophages as well as being positive for the monocyte-specific stain α-naphtyl-acetate esterase. These myelomonocytic leukemia cell lines can also be induced in culture by speen cell-conditioned medium to differentiate into macrophages. Other conditioned media such as L-cell-conditioned medium, phytophemmaglutinin-stimulated leukocyte-conditioned medium, and WEHI-3 conditioned medium were less effective in their abilities to stimulate differentiation in these myelomonocytic leukemia cell lines.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041170302
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  • 7
    Electronic Resource
    Electronic Resource
    Induction of erythroid tumorigenic colonies by friend helper virus F-MuLV alone and isolation of a new class of friend erythroleukemic cells (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 113 (1982), S. 185-194 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Friend erythroleukemia virus (FLV) is a complex of two viruses, a defective spleen focus virus component (SFFV) and a helper independent virus, F-MuLV. The virus complex induces in susceptible mice a multistage disease, an early stage (1-3 weeks) of rapid erythropoietic changes and a late stage, from which erythroleukemic cell lines (FLC) can be established. While the F-MuLV alone does not induce any detectable changes in adult mice, it has been found recently to induce, in newborn BALB/c and NIH/Swiss mice, splenomegaly and certain early erythropoietic changes. The present study indicates that if the infected mice were kept alive by red cell transfusion and the cells from these F-MuLV-induced enlarged spleens were transplanted repeatedly in adult mice, erythroid tumorigenic colonies (CFU-FV) can be detected. These helper virus of induced CFU-FV (CFU-FV-H) have properties that differed from those CFU-FVs induced by the FLV complexes. The colonies are more diffuse in morphology and do not release any detectable SFFV activities. In addition, FLC lines can also be established from these F-MuLV infected spleens and CFU-FV-H and have been in culture for eight months. They are found to be distinct from those established from CFU-FV induced by the FLV complexes. First, these FLC lines are more selective in the type of medium they can grow in, for while FLC lines induced by FLV complexes will grow in both α-medium and Iscove medium, the FLC induced by F-MuLV will only grow in Iscove medium and not in α-medium. Secondly, the growth of the F-MuLV induced FLC lines are cell density dependent and will not proliferate below 105 cells/ml. Thirdly, the growth of the F-MuLV-induced FLC lines can be greatly enhanced by the addition of erythropoietin (epo). Finally, the F-MuLV induced FLC lines will not respond to either dimethylsulphoxide (DMSO) or epo to induce along the erythroid pathway. These studies indicate that similar to the disease induced by FLV complexes, the erythroleukemia induced by F-MuLV is also a multistage disease and a new class of erythroid tumorigenic cells and FLC lines can also be established from the spleens of these mice infected by the F-MuLV alone.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041130426
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