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  • 1
    Electronic Resource
    Electronic Resource
    Apoptosis Regulates the Number of Schwann Cells at the Premyelinating Stage (1997)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 68 (1997), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: At the premyelinating stage, the Schwann cells of peripheral nerves are able to recognize the axon, to arrange themselves along it in a nonoverlapping manner, and finally to establish a one-to-one cell-axon relationship. The mechanism that regulates these processes is not known in detail. We found the existence of a significant Schwann cell apoptosis in vivo of rat postnatal sciatic nerve, peaking around postnatal day 3. More than 50% of the neonatal Schwann cells cultured in axon-free medium undergo a rapid apoptosis. The apoptosis can be suppressed by addition of survival factors such as Neu differentiation factors or by increasing the adhesion of Schwann cells to substratum. We suggest that in neonatal nerves in vivo, Schwann cells are highly susceptible to apoptosis, but they are saved from death by contact with axons. The dramatic increase in number of Schwann cells between postnatal day 0 and 3 overcomes the number of axons available for them. Consequently the Schwann cells that fail to contact an axon undergo apoptosis. In conclusion, the number of Schwann cells in the developing nerves is regulated by the apoptosis and clearly depends on the survival signals from axons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1997.68051853.x
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  • 2
    Electronic Resource
    Electronic Resource
    Postnatal development and enlargement of primary middle cranial fossa arachnoid cyst recognized on repeat CT scans (1986)
    Springer
    Child's nervous system 2 (1986), S. 211-215 
    Details
    ISSN: 1433-0350
    Keywords: Arachnoid cyst ; Computed tomography ; Ball-valve mechanism ; Middle cranial fossa ; Postnatal occurrence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The etiology and mechanism of expansion of primary intracranial arachnoid cysts have been much debated. A rare case of an 8-month-old boy is reported, in which postnatal development and enlargement of a middle cranial fossa arachnoid cyst was detected on follow-up CT scans. Based on intraoperative and histological findings, the cyst was found to be intra-arachnoid. The wall was excised completely, and the lobe adjacent to the cyst appeared normal apart from signs of atrophy. Histological study of the excised cyst revealed a common arachnoid membrane with neither ependymal nor inflammatory cells; the cyst fluid was similar to CSF. The etiology of the lesion remains unclear, but it was considered that the expansion of the cyst might have occurred through a ball-valve mechanism of the membrane in communication with the general subarachnoid space.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00706815
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical trial of external beam-radiotherapy combined with daily administration of low-dose cisplatin for supratentorial glioblastoma multiforme – A pilot study (1997)
    Springer
    Journal of neuro-oncology 35 (1997), S. 73-80 
    Details
    ISSN: 1573-7373
    Keywords: glioblastoma multiforme ; external beam-radiotherapy ; CDDP ; intraoperative radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This trial tested the assumed efficacy and safety of externalbeam-radiotherapy combined with daily administration of low dose cisplatin(CDDP) (ERCLC therapy) for patients with glioblastoma multiforme (GBM).Thirty adult patients with supratentorial GBM received daily postoperativetreatment with low dose intravenous CDDP (4–6 mg/m2) administered30 minutes before external irradiation. In 10 patients, intraoperativeradiotherapy (IORT) following surgery was given prior to ERCLC therapy.Tumor response on MRI, interval to tumor progression, survival, andtoxicities were analyzed. None of the patients showed a tumor response toERCLC therapy. Overall, the median time to tumor progression was 6 monthswith a 1-year tumor progression-free rate of 26.7% and a 2-year rateof 0%. The median survival time was 15 months with a 1-year survivalrate of 69.9% and a 2-year rate of 31.5%. The survival rate ofpatients with IORT was better than that of those without IORT, however,there was no significant difference. Anorexia associated with nauseaoccurred in 70% and general fatigue in 10.0%. Leukopenia andthrombocytopenia occurred in 26.7% and 33.3%, respectively.However, none of the patients had to be withdrawn from therapy due to thesetoxicities. Other toxicities were not observed. This clinical study showedthat daily administration of low dose CDDP did not enhance tumor response toirradiation for GBM on MRI. Regarding toxicity, however, ERCLC therapy waswell tolerated. Although this trial did not provide sufficient data todetermine whether ERCLC therapy was effective for GBM due to the smallnumber of patients, additional clinical trials of this therapy may bewarranted because that the survival rate in this study was equal to thebetter results recently reported for newly diagnosed GBM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005816320920
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  • 4
    Electronic Resource
    Electronic Resource
    Primary osteosarcoma of the skull (1993)
    Springer
    Journal of neuro-oncology 17 (1993), S. 81-88 
    Details
    ISSN: 1573-7373
    Keywords: osteosarcoma ; skull tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Primary osteosarcoma of the skull (POS) in a young man with intracranial involvement is reported. After an initial transient remission by surgical intervention and chemotherapy, he began to deteriorate due to tumor recurrence and intracranial hemorrhage, and died 15 months following the time of diagnosis. The rarity and poor prognosis of POS are emphasized together with the review of the clinical and therapeutic aspects in the previously reported 98 cases in the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01054277
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  • 5
    Electronic Resource
    Electronic Resource
    The Significance of the Expression of Tumor Suppressor Gene DCC in Human Gliomas (1998)
    Springer
    Journal of neuro-oncology 40 (1998), S. 237-242 
    Details
    ISSN: 1573-7373
    Keywords: DCC ; glioma ; RT-PCR ; recurrent tumor ; survival rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Deleted in colorectal carcinoma (DCC) gene has been as a candidate of tumor suppressor genes, has been identified recently and is thought to relate to the metastatic potential in some cancers. We examined the gene in 60 human gliomas (26 glioblastomas multiforme (GBMs), 16 anaplastic astrocytomas (AAs), 6 low grade astrocytomas (LGAs) of WHO Grade II, and 11 recurrent gliomas) and A172 human GBM cell line by reverse transcription polymerase chain reaction (RT-PCR). Twenty (77%) GBMs, 11 (69%) AAs, and 1 (17%) LGA revealed the reduced or absent DCC expression. Reduced DCC expression was also shown in 10 (91%) recurrent gliomas. Furthermore, in 5 cases with both primary and recurrent GBM, the DCC expressions of all recurrent tumors were lower than those of primary tumors. No significant correlation between DCC expression and Mib-1 labeling index was confirmed. The survival rate of patients without reduced DCC expression was significantly superior to that of patients with reduced DCC expression in overall malignant astrocytic tumors. In GBM and AA separately, DCC expression also tended to correlate with patient's prognosis. These results suggest that reduced DCC expression is an important marker in tumor malignancy and recurrence in astrocytic tumors and that may be a useful prognostic factor in patients with malignant astrocytic tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006114328134
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  • 6
    Electronic Resource
    Electronic Resource
    Primary pleomorphic adenoma in posterior cranial fossa (1997)
    Springer
    Brain tumor pathology 14 (1997), S. 75-78 
    Details
    ISSN: 1861-387X
    Keywords: Pleomorphic adenoma ; Intracranial ; Posterior fossa ; Apocrine gland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 35-year-old woman had an intradural tumor in the posterior fossa adjacent to the posterior wall of the left pyramidal bone, which was totally removed and histologically diagnosed as a pleomorphic adenoma. Follow-up examination for 2 years showed no recurrence of the tumor. There was no primary lesion in any other gland of the body, and therefore there is no alternative but to conclude a “migration” of some gland cells. The pathogenesis of this tumor remains unclassified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02478873
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  • 7
    Electronic Resource
    Electronic Resource
    Chordoid meningioma (2000)
    Springer
    Brain tumor pathology 17 (2000), S. 153-157 
    Details
    ISSN: 1861-387X
    Keywords: Chordoid meningioma ; Castleman syndrome ; Electron microscopy ; Immunohistochemistry ; Magnetic resonance image
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chordoid meningioma is a relatively rare variant that is often associated with peritumoral lymphoplasmacellular infiltration causing Castleman syndrome (CS). We present a 44-year-old woman with chordoid meningioma not associated with CS. The patient presented with epilepsy and right hemiparesis (Todd's palsy) on admission. The radiological findings revealed an extraaxial mass lesion in the premotor cortex. They were compatible with a preoperative diagnosis of meningioma. No physical abnormalities related to CS were detected. A left frontal craniotomy was performed. The tumor surface was gelatinous, and it was totally resected with the attached dura mater (Simpson grade I). The patient had an uneventful recovery, and her seizures subsided. The pathological findings of the specimens revealed nests and cords of spindle and epithelioid cells with abundant myxoid matrix, mimicking the features of chordoma. On the basis of radiological, immunohistochemical, and electron microscopic findings, chordoid meningioma was verified, and a review of the literature was performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02484287
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